The mechanism of action of piroxicam, like that of other NSAIDs, is not completely understood but may be related to prostaglandin synthetase inhibition.
Distribution
The apparent volume of distribution of piroxicam is approximately 0.14L/kg. Ninety-nine percent of plasma piroxicam is bound to plasma proteins. Piroxicam is excreted into human milk. The presence in breast milk has been determined during initial and long-term conditions (52 days). Piroxicam appeared in breast milk at about 1% to 3% of the maternal concentration. No accumulation of piroxicam occurred in milk relative to that in plasma during treatment.
Metabolism
Metabolism of piroxicam occurs by hydroxylation at the 5 position of the pyridyl side chain and conjugation of this product; by cyclodehydration; and by a sequence of reactions involving hydrolysis of the amide linkage, decarboxylation, ring contraction, and N-demethylation. The biotransformation products of piroxicam metabolism are reported to not have any anti-inflammatory activity.
Excretion
Piroxicam and its biotransformation products are excreted in urine and feces, with about twice as much appearing in the urine as in the feces. Approximately 5% of a Piroxicam dose is excreted unchanged. The plasma half-life (T½) for Piroxicam is approximately 50 hours.
• osteoarthritis
• rheumatoid arthritis
• ankylosing spondylitis
• primary dysmenorrhea
• Hypersensitivity to drug or other NSAIDs (including aspirin)
• Third trimester of pregnancy
• renal impairment, severe cardiovascular or hepatic disease
• pregnant patients in first or secondtrimester
• breastfeeding patients (not recommended)
• children (safety not established).
Acetaminophen (chronic use), cyclosporine, gold compounds: increased risk of adverse renal reactions
Anticoagulants, cefamandole, cefoperazone, cefotetan, clopidogrel, eptifibatide, heparin, plicamycin, thrombolytics, ticlopidine, tirofiban, valproic acid, vitamin A: increased risk of bleeding
Antineoplastics: increased risk of hematologic toxicity
Aspirin: decreased piroxicam blood level and efficacy
Corticosteroids, other NSAIDs: additive adverse GI reactions
Diuretics, other antihypertensives: decreased response to these drugs
Insulin, oral hypoglycemics: increased risk of hypoglycemia
Lithium: increased lithium blood level and risk of toxicity
Probenecid: increased piroxicam blood level and risk of toxicity
CNS: headache, drowsiness, dizziness
CV: edema, hypertension, vasculitis, tachycardia, arrhythmias
EENT: blurred vision, tinnitus
GU: proteinuria, renal failure
Hematologic: anemia, blood dyscrasias
Hepatic: jaundice, hepatitis
Skin: rash
Other: allergic reactions including anaphylaxis
• Store below 30 C°
• Protect from light and freezing
Piroxicam injection 20mg /ml : 10 ampoules/box
Piroxicam 0.5% topical gel : 1 tube/box- 60 g
Rocamix®
0.5% Topical Gel
Non-steroidal anti-inflammatory drug (NSAID)
Analgesic, anti-inflammatory, antipyretic
category C
The mechanism of action of piroxicam, like that of other NSAIDs, is not completely understood but may be related to prostaglandin synthetase inhibition.
Distribution
The apparent volume of distribution of piroxicam is approximately 0.14L/kg. Ninety-nine percent of plasma piroxicam is bound to plasma proteins. Piroxicam is excreted into human milk. The presence in breast milk has been determined during initial and long-term conditions (52 days). Piroxicam appeared in breast milk at about 1% to 3% of the maternal concentration. No accumulation of piroxicam occurred in milk relative to that in plasma during treatment.
Metabolism
Metabolism of piroxicam occurs by hydroxylation at the 5 position of the pyridyl side chain and conjugation of this product; by cyclodehydration; and by a sequence of reactions involving hydrolysis of the amide linkage, decarboxylation, ring contraction, and N-demethylation. The biotransformation products of piroxicam metabolism are reported to not have any anti-inflammatory activity.
Excretion
Piroxicam and its biotransformation products are excreted in urine and feces, with about twice as much appearing in the urine as in the feces. Approximately 5% of a Piroxicam dose is excreted unchanged. The plasma half-life (T½) for Piroxicam is approximately 50 hours.
• osteoarthritis
• rheumatoid arthritis
• ankylosing spondylitis
• primary dysmenorrhea
• Hypersensitivity to drug or other NSAIDs (including aspirin)
• Third trimester of pregnancy
• renal impairment, severe cardiovascular or hepatic disease
• pregnant patients in first or secondtrimester
• breastfeeding patients (not recommended)
• children (safety not established).
Acetaminophen (chronic use), cyclosporine, gold compounds: increased risk of adverse renal reactions
Anticoagulants, cefamandole, cefoperazone, cefotetan, clopidogrel, eptifibatide, heparin, plicamycin, thrombolytics, ticlopidine, tirofiban, valproic acid, vitamin A: increased risk of bleeding
Antineoplastics: increased risk of hematologic toxicity
Aspirin: decreased piroxicam blood level and efficacy
Corticosteroids, other NSAIDs: additive adverse GI reactions
Diuretics, other antihypertensives: decreased response to these drugs
Insulin, oral hypoglycemics: increased risk of hypoglycemia
Lithium: increased lithium blood level and risk of toxicity
Probenecid: increased piroxicam blood level and risk of toxicity
CNS: headache, drowsiness, dizziness
CV: edema, hypertension, vasculitis, tachycardia, arrhythmias
EENT: blurred vision, tinnitus
GU: proteinuria, renal failure
Hematologic: anemia, blood dyscrasias
Hepatic: jaundice, hepatitis
Skin: rash
Other: allergic reactions including anaphylaxis
• Store below 30 C°
• Protect from light and freezing
Piroxicam injection 20mg /ml : 10 ampoules/box
Piroxicam 0.5% topical gel : 1 tube/box- 60 g
Rocamix®
[view] =>Rocamix®
) ) [field_contraindications] => Array ( [0] => Array ( [value] => • Hypersensitivity to drug or other NSAIDs (including aspirin) • Third trimester of pregnancy [format] => 1 [safe] =>• Hypersensitivity to drug or other NSAIDs (including aspirin)
• Third trimester of pregnancy
• Hypersensitivity to drug or other NSAIDs (including aspirin)
• Third trimester of pregnancy
0.5% Topical Gel
[view] =>0.5% Topical Gel
) ) [field_drug_interactions] => Array ( [0] => Array ( [value] => Acetaminophen (chronic use), cyclosporine, gold compounds: increased risk of adverse renal reactions Anticoagulants, cefamandole, cefoperazone, cefotetan, clopidogrel, eptifibatide, heparin, plicamycin, thrombolytics, ticlopidine, tirofiban, valproic acid, vitamin A: increased risk of bleeding Antineoplastics: increased risk of hematologic toxicity Aspirin: decreased piroxicam blood level and efficacy Corticosteroids, other NSAIDs: additive adverse GI reactions Diuretics, other antihypertensives: decreased response to these drugs Insulin, oral hypoglycemics: increased risk of hypoglycemia Lithium: increased lithium blood level and risk of toxicity Probenecid: increased piroxicam blood level and risk of toxicity [format] => 1 [safe] =>Acetaminophen (chronic use), cyclosporine, gold compounds: increased risk of adverse renal reactions
Anticoagulants, cefamandole, cefoperazone, cefotetan, clopidogrel, eptifibatide, heparin, plicamycin, thrombolytics, ticlopidine, tirofiban, valproic acid, vitamin A: increased risk of bleeding
Antineoplastics: increased risk of hematologic toxicity
Aspirin: decreased piroxicam blood level and efficacy
Corticosteroids, other NSAIDs: additive adverse GI reactions
Diuretics, other antihypertensives: decreased response to these drugs
Insulin, oral hypoglycemics: increased risk of hypoglycemia
Lithium: increased lithium blood level and risk of toxicity
Probenecid: increased piroxicam blood level and risk of toxicity
Acetaminophen (chronic use), cyclosporine, gold compounds: increased risk of adverse renal reactions
Anticoagulants, cefamandole, cefoperazone, cefotetan, clopidogrel, eptifibatide, heparin, plicamycin, thrombolytics, ticlopidine, tirofiban, valproic acid, vitamin A: increased risk of bleeding
Antineoplastics: increased risk of hematologic toxicity
Aspirin: decreased piroxicam blood level and efficacy
Corticosteroids, other NSAIDs: additive adverse GI reactions
Diuretics, other antihypertensives: decreased response to these drugs
Insulin, oral hypoglycemics: increased risk of hypoglycemia
Lithium: increased lithium blood level and risk of toxicity
Probenecid: increased piroxicam blood level and risk of toxicity
• osteoarthritis
• rheumatoid arthritis
• ankylosing spondylitis
• primary dysmenorrhea
• osteoarthritis
• rheumatoid arthritis
• ankylosing spondylitis
• primary dysmenorrhea
Piroxicam injection 20mg /ml : 10 ampoules/box
Piroxicam 0.5% topical gel : 1 tube/box- 60 g
Piroxicam injection 20mg /ml : 10 ampoules/box
Piroxicam 0.5% topical gel : 1 tube/box- 60 g
Distribution
The apparent volume of distribution of piroxicam is approximately 0.14L/kg. Ninety-nine percent of plasma piroxicam is bound to plasma proteins. Piroxicam is excreted into human milk. The presence in breast milk has been determined during initial and long-term conditions (52 days). Piroxicam appeared in breast milk at about 1% to 3% of the maternal concentration. No accumulation of piroxicam occurred in milk relative to that in plasma during treatment.
Metabolism
Metabolism of piroxicam occurs by hydroxylation at the 5 position of the pyridyl side chain and conjugation of this product; by cyclodehydration; and by a sequence of reactions involving hydrolysis of the amide linkage, decarboxylation, ring contraction, and N-demethylation. The biotransformation products of piroxicam metabolism are reported to not have any anti-inflammatory activity.
Excretion
Piroxicam and its biotransformation products are excreted in urine and feces, with about twice as much appearing in the urine as in the feces. Approximately 5% of a Piroxicam dose is excreted unchanged. The plasma half-life (T½) for Piroxicam is approximately 50 hours.
Distribution
The apparent volume of distribution of piroxicam is approximately 0.14L/kg. Ninety-nine percent of plasma piroxicam is bound to plasma proteins. Piroxicam is excreted into human milk. The presence in breast milk has been determined during initial and long-term conditions (52 days). Piroxicam appeared in breast milk at about 1% to 3% of the maternal concentration. No accumulation of piroxicam occurred in milk relative to that in plasma during treatment.
Metabolism
Metabolism of piroxicam occurs by hydroxylation at the 5 position of the pyridyl side chain and conjugation of this product; by cyclodehydration; and by a sequence of reactions involving hydrolysis of the amide linkage, decarboxylation, ring contraction, and N-demethylation. The biotransformation products of piroxicam metabolism are reported to not have any anti-inflammatory activity.
Excretion
Piroxicam and its biotransformation products are excreted in urine and feces, with about twice as much appearing in the urine as in the feces. Approximately 5% of a Piroxicam dose is excreted unchanged. The plasma half-life (T½) for Piroxicam is approximately 50 hours.
Non-steroidal anti-inflammatory drug (NSAID)
[view] =>Non-steroidal anti-inflammatory drug (NSAID)
) ) [field_precautions] => Array ( [0] => Array ( [value] => • renal impairment, severe cardiovascular or hepatic disease • pregnant patients in first or secondtrimester • breastfeeding patients (not recommended) • children (safety not established). [format] => 1 [safe] =>• renal impairment, severe cardiovascular or hepatic disease
• pregnant patients in first or secondtrimester
• breastfeeding patients (not recommended)
• children (safety not established).
• renal impairment, severe cardiovascular or hepatic disease
• pregnant patients in first or secondtrimester
• breastfeeding patients (not recommended)
• children (safety not established).
category C
[view] =>category C
) ) [field_references] => Array ( [0] => Array ( [value] => [format] => [safe] => [view] => ) ) [field_side_effects] => Array ( [0] => Array ( [value] => CNS: headache, drowsiness, dizziness CV: edema, hypertension, vasculitis, tachycardia, arrhythmias EENT: blurred vision, tinnitus GU: proteinuria, renal failure Hematologic: anemia, blood dyscrasias Hepatic: jaundice, hepatitis Skin: rash Other: allergic reactions including anaphylaxis [format] => 1 [safe] =>CNS: headache, drowsiness, dizziness
CV: edema, hypertension, vasculitis, tachycardia, arrhythmias
EENT: blurred vision, tinnitus
GU: proteinuria, renal failure
Hematologic: anemia, blood dyscrasias
Hepatic: jaundice, hepatitis
Skin: rash
Other: allergic reactions including anaphylaxis
CNS: headache, drowsiness, dizziness
CV: edema, hypertension, vasculitis, tachycardia, arrhythmias
EENT: blurred vision, tinnitus
GU: proteinuria, renal failure
Hematologic: anemia, blood dyscrasias
Hepatic: jaundice, hepatitis
Skin: rash
Other: allergic reactions including anaphylaxis
• Store below 30 C°
• Protect from light and freezing
• Store below 30 C°
• Protect from light and freezing
Analgesic, anti-inflammatory, antipyretic
[view] =>Analgesic, anti-inflammatory, antipyretic
) ) [field_related_products] => Array ( [0] => Array ( [nid] => [i18nsync] => 1 [safe] => Array ( ) [view] => ) [1] => Array ( [nid] => [i18nsync] => 1 [safe] => Array ( ) [view] => ) [2] => Array ( [nid] => [i18nsync] => 1 [safe] => Array ( ) [view] => ) ) [taxonomy] => Array ( [21] => stdClass Object ( [tid] => 21 [vid] => 1 [name] => Anlagesics Anti-inflammatory Drugs [description] => [weight] => 0 [language] => [trid] => 0 [v_weight_unused] => 0 ) ) [build_mode] => 0 [readmore] => [content] => Array ( [field_one_image] => Array ( [#type_name] => product [#context] => full [#field_name] => field_one_image [#post_render] => Array ( [0] => content_field_wrapper_post_render ) [#weight] => -3 [field] => Array ( [#description] => [items] => Array ( [0] => Array ( [#formatter] => image_plain [#node] => stdClass Object *RECURSION* [#type_name] => product [#field_name] => field_one_image [#weight] => 0 [#theme] => imagefield_formatter_image_plain [#item] => Array ( [fid] => 796 [uid] => 1 [filename] => piroxicam_s.jpg [filepath] => sites/default/files/images/piroxicam_s.jpg [filemime] => image/jpeg [filesize] => 13874 [status] => 1 [timestamp] => 1373570507 [list] => 1 [data] => Array ( [alt] => [title] => ) [i18nsync] => 1 [nid] => 224 [#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] => ) [#title] => [#description] => [#children] => [#printed] => 1 ) [#single] => 1 [#attributes] => Array ( ) [#required] => [#parents] => Array ( ) [#tree] => [#context] => full [#page] => 1 [#field_name] => field_one_image [#title] => Image [#access] => 1 [#label_display] => above [#teaser] => [#node] => stdClass Object *RECURSION* [#type] => content_field [#children] => [#printed] => 1 ) [#title] => [#description] => [#children] =>Rocamix®
[#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] =>Rocamix®
) [#title] => [#description] => [#children] =>Rocamix®
[#printed] => 1 ) [#single] => 1 [#attributes] => Array ( ) [#required] => [#parents] => Array ( ) [#tree] => [#context] => full [#page] => 1 [#field_name] => field_brand_name [#title] => Brand Name [#access] => 1 [#label_display] => above [#teaser] => [#node] => stdClass Object *RECURSION* [#type] => content_field [#children] =>Rocamix®
[#printed] => 1 ) [#title] => [#description] => [#children] =>Rocamix®
0.5% Topical Gel
[#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] =>0.5% Topical Gel
) [#title] => [#description] => [#children] =>0.5% Topical Gel
[#printed] => 1 ) [#single] => 1 [#attributes] => Array ( ) [#required] => [#parents] => Array ( ) [#tree] => [#context] => full [#page] => 1 [#field_name] => field_dosage_form [#title] => Dosage Form [#access] => 1 [#label_display] => above [#teaser] => [#node] => stdClass Object *RECURSION* [#type] => content_field [#children] =>0.5% Topical Gel
[#printed] => 1 ) [#title] => [#description] => [#children] =>0.5% Topical Gel
Non-steroidal anti-inflammatory drug (NSAID)
[#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] =>Non-steroidal anti-inflammatory drug (NSAID)
) [#title] => [#description] => [#children] =>Non-steroidal anti-inflammatory drug (NSAID)
[#printed] => 1 ) [#single] => 1 [#attributes] => Array ( ) [#required] => [#parents] => Array ( ) [#tree] => [#context] => full [#page] => 1 [#field_name] => field_pharmacological_category [#title] => Pharmacological Category [#access] => 1 [#label_display] => above [#teaser] => [#node] => stdClass Object *RECURSION* [#type] => content_field [#children] =>Non-steroidal anti-inflammatory drug (NSAID)
[#printed] => 1 ) [#title] => [#description] => [#children] =>Non-steroidal anti-inflammatory drug (NSAID)
Analgesic, anti-inflammatory, antipyretic
[#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] =>Analgesic, anti-inflammatory, antipyretic
) [#title] => [#description] => [#children] =>Analgesic, anti-inflammatory, antipyretic
[#printed] => 1 ) [#single] => 1 [#attributes] => Array ( ) [#required] => [#parents] => Array ( ) [#tree] => [#context] => full [#page] => 1 [#field_name] => field_therapeutic_category [#title] => Therapeutic Category [#access] => 1 [#label_display] => above [#teaser] => [#node] => stdClass Object *RECURSION* [#type] => content_field [#children] =>Analgesic, anti-inflammatory, antipyretic
[#printed] => 1 ) [#title] => [#description] => [#children] =>Analgesic, anti-inflammatory, antipyretic
category C
[#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] =>category C
) [#title] => [#description] => [#children] =>category C
[#printed] => 1 ) [#single] => 1 [#attributes] => Array ( ) [#required] => [#parents] => Array ( ) [#tree] => [#context] => full [#page] => 1 [#field_name] => field_pregnancy_category [#title] => Pregnancy Category [#access] => 1 [#label_display] => above [#teaser] => [#node] => stdClass Object *RECURSION* [#type] => content_field [#children] =>category C
[#printed] => 1 ) [#title] => [#description] => [#children] =>category C
The mechanism of action of piroxicam, like that of other NSAIDs, is not completely understood but may be related to prostaglandin synthetase inhibition.
[#title] => [#description] => [#printed] => 1 ) [field_pharmacokinetics] => Array ( [#type_name] => product [#context] => full [#field_name] => field_pharmacokinetics [#post_render] => Array ( [0] => content_field_wrapper_post_render ) [#weight] => 4 [field] => Array ( [#description] => [items] => Array ( [0] => Array ( [#formatter] => default [#node] => stdClass Object *RECURSION* [#type_name] => product [#field_name] => field_pharmacokinetics [#weight] => 0 [#theme] => text_formatter_default [#item] => Array ( [value] => Distribution The apparent volume of distribution of piroxicam is approximately 0.14L/kg. Ninety-nine percent of plasma piroxicam is bound to plasma proteins. Piroxicam is excreted into human milk. The presence in breast milk has been determined during initial and long-term conditions (52 days). Piroxicam appeared in breast milk at about 1% to 3% of the maternal concentration. No accumulation of piroxicam occurred in milk relative to that in plasma during treatment. Metabolism Metabolism of piroxicam occurs by hydroxylation at the 5 position of the pyridyl side chain and conjugation of this product; by cyclodehydration; and by a sequence of reactions involving hydrolysis of the amide linkage, decarboxylation, ring contraction, and N-demethylation. The biotransformation products of piroxicam metabolism are reported to not have any anti-inflammatory activity. Excretion Piroxicam and its biotransformation products are excreted in urine and feces, with about twice as much appearing in the urine as in the feces. Approximately 5% of a Piroxicam dose is excreted unchanged. The plasma half-life (T½) for Piroxicam is approximately 50 hours. [format] => 1 [safe] =>Distribution
The apparent volume of distribution of piroxicam is approximately 0.14L/kg. Ninety-nine percent of plasma piroxicam is bound to plasma proteins. Piroxicam is excreted into human milk. The presence in breast milk has been determined during initial and long-term conditions (52 days). Piroxicam appeared in breast milk at about 1% to 3% of the maternal concentration. No accumulation of piroxicam occurred in milk relative to that in plasma during treatment.
Metabolism
Metabolism of piroxicam occurs by hydroxylation at the 5 position of the pyridyl side chain and conjugation of this product; by cyclodehydration; and by a sequence of reactions involving hydrolysis of the amide linkage, decarboxylation, ring contraction, and N-demethylation. The biotransformation products of piroxicam metabolism are reported to not have any anti-inflammatory activity.
Excretion
Piroxicam and its biotransformation products are excreted in urine and feces, with about twice as much appearing in the urine as in the feces. Approximately 5% of a Piroxicam dose is excreted unchanged. The plasma half-life (T½) for Piroxicam is approximately 50 hours.
Distribution
The apparent volume of distribution of piroxicam is approximately 0.14L/kg. Ninety-nine percent of plasma piroxicam is bound to plasma proteins. Piroxicam is excreted into human milk. The presence in breast milk has been determined during initial and long-term conditions (52 days). Piroxicam appeared in breast milk at about 1% to 3% of the maternal concentration. No accumulation of piroxicam occurred in milk relative to that in plasma during treatment.
Metabolism
Metabolism of piroxicam occurs by hydroxylation at the 5 position of the pyridyl side chain and conjugation of this product; by cyclodehydration; and by a sequence of reactions involving hydrolysis of the amide linkage, decarboxylation, ring contraction, and N-demethylation. The biotransformation products of piroxicam metabolism are reported to not have any anti-inflammatory activity.
Excretion
Piroxicam and its biotransformation products are excreted in urine and feces, with about twice as much appearing in the urine as in the feces. Approximately 5% of a Piroxicam dose is excreted unchanged. The plasma half-life (T½) for Piroxicam is approximately 50 hours.
Distribution
The apparent volume of distribution of piroxicam is approximately 0.14L/kg. Ninety-nine percent of plasma piroxicam is bound to plasma proteins. Piroxicam is excreted into human milk. The presence in breast milk has been determined during initial and long-term conditions (52 days). Piroxicam appeared in breast milk at about 1% to 3% of the maternal concentration. No accumulation of piroxicam occurred in milk relative to that in plasma during treatment.
Metabolism
Metabolism of piroxicam occurs by hydroxylation at the 5 position of the pyridyl side chain and conjugation of this product; by cyclodehydration; and by a sequence of reactions involving hydrolysis of the amide linkage, decarboxylation, ring contraction, and N-demethylation. The biotransformation products of piroxicam metabolism are reported to not have any anti-inflammatory activity.
Excretion
Piroxicam and its biotransformation products are excreted in urine and feces, with about twice as much appearing in the urine as in the feces. Approximately 5% of a Piroxicam dose is excreted unchanged. The plasma half-life (T½) for Piroxicam is approximately 50 hours.
Distribution
The apparent volume of distribution of piroxicam is approximately 0.14L/kg. Ninety-nine percent of plasma piroxicam is bound to plasma proteins. Piroxicam is excreted into human milk. The presence in breast milk has been determined during initial and long-term conditions (52 days). Piroxicam appeared in breast milk at about 1% to 3% of the maternal concentration. No accumulation of piroxicam occurred in milk relative to that in plasma during treatment.
Metabolism
Metabolism of piroxicam occurs by hydroxylation at the 5 position of the pyridyl side chain and conjugation of this product; by cyclodehydration; and by a sequence of reactions involving hydrolysis of the amide linkage, decarboxylation, ring contraction, and N-demethylation. The biotransformation products of piroxicam metabolism are reported to not have any anti-inflammatory activity.
Excretion
Piroxicam and its biotransformation products are excreted in urine and feces, with about twice as much appearing in the urine as in the feces. Approximately 5% of a Piroxicam dose is excreted unchanged. The plasma half-life (T½) for Piroxicam is approximately 50 hours.
Distribution
The apparent volume of distribution of piroxicam is approximately 0.14L/kg. Ninety-nine percent of plasma piroxicam is bound to plasma proteins. Piroxicam is excreted into human milk. The presence in breast milk has been determined during initial and long-term conditions (52 days). Piroxicam appeared in breast milk at about 1% to 3% of the maternal concentration. No accumulation of piroxicam occurred in milk relative to that in plasma during treatment.
Metabolism
Metabolism of piroxicam occurs by hydroxylation at the 5 position of the pyridyl side chain and conjugation of this product; by cyclodehydration; and by a sequence of reactions involving hydrolysis of the amide linkage, decarboxylation, ring contraction, and N-demethylation. The biotransformation products of piroxicam metabolism are reported to not have any anti-inflammatory activity.
Excretion
Piroxicam and its biotransformation products are excreted in urine and feces, with about twice as much appearing in the urine as in the feces. Approximately 5% of a Piroxicam dose is excreted unchanged. The plasma half-life (T½) for Piroxicam is approximately 50 hours.
• osteoarthritis
• rheumatoid arthritis
• ankylosing spondylitis
• primary dysmenorrhea
• osteoarthritis
• rheumatoid arthritis
• ankylosing spondylitis
• primary dysmenorrhea
• osteoarthritis
• rheumatoid arthritis
• ankylosing spondylitis
• primary dysmenorrhea
• osteoarthritis
• rheumatoid arthritis
• ankylosing spondylitis
• primary dysmenorrhea
• osteoarthritis
• rheumatoid arthritis
• ankylosing spondylitis
• primary dysmenorrhea
• Hypersensitivity to drug or other NSAIDs (including aspirin)
• Third trimester of pregnancy
• Hypersensitivity to drug or other NSAIDs (including aspirin)
• Third trimester of pregnancy
• Hypersensitivity to drug or other NSAIDs (including aspirin)
• Third trimester of pregnancy
• Hypersensitivity to drug or other NSAIDs (including aspirin)
• Third trimester of pregnancy
• Hypersensitivity to drug or other NSAIDs (including aspirin)
• Third trimester of pregnancy
• renal impairment, severe cardiovascular or hepatic disease
• pregnant patients in first or secondtrimester
• breastfeeding patients (not recommended)
• children (safety not established).
• renal impairment, severe cardiovascular or hepatic disease
• pregnant patients in first or secondtrimester
• breastfeeding patients (not recommended)
• children (safety not established).
• renal impairment, severe cardiovascular or hepatic disease
• pregnant patients in first or secondtrimester
• breastfeeding patients (not recommended)
• children (safety not established).
• renal impairment, severe cardiovascular or hepatic disease
• pregnant patients in first or secondtrimester
• breastfeeding patients (not recommended)
• children (safety not established).
• renal impairment, severe cardiovascular or hepatic disease
• pregnant patients in first or secondtrimester
• breastfeeding patients (not recommended)
• children (safety not established).
Acetaminophen (chronic use), cyclosporine, gold compounds: increased risk of adverse renal reactions
Anticoagulants, cefamandole, cefoperazone, cefotetan, clopidogrel, eptifibatide, heparin, plicamycin, thrombolytics, ticlopidine, tirofiban, valproic acid, vitamin A: increased risk of bleeding
Antineoplastics: increased risk of hematologic toxicity
Aspirin: decreased piroxicam blood level and efficacy
Corticosteroids, other NSAIDs: additive adverse GI reactions
Diuretics, other antihypertensives: decreased response to these drugs
Insulin, oral hypoglycemics: increased risk of hypoglycemia
Lithium: increased lithium blood level and risk of toxicity
Probenecid: increased piroxicam blood level and risk of toxicity
Acetaminophen (chronic use), cyclosporine, gold compounds: increased risk of adverse renal reactions
Anticoagulants, cefamandole, cefoperazone, cefotetan, clopidogrel, eptifibatide, heparin, plicamycin, thrombolytics, ticlopidine, tirofiban, valproic acid, vitamin A: increased risk of bleeding
Antineoplastics: increased risk of hematologic toxicity
Aspirin: decreased piroxicam blood level and efficacy
Corticosteroids, other NSAIDs: additive adverse GI reactions
Diuretics, other antihypertensives: decreased response to these drugs
Insulin, oral hypoglycemics: increased risk of hypoglycemia
Lithium: increased lithium blood level and risk of toxicity
Probenecid: increased piroxicam blood level and risk of toxicity
Acetaminophen (chronic use), cyclosporine, gold compounds: increased risk of adverse renal reactions
Anticoagulants, cefamandole, cefoperazone, cefotetan, clopidogrel, eptifibatide, heparin, plicamycin, thrombolytics, ticlopidine, tirofiban, valproic acid, vitamin A: increased risk of bleeding
Antineoplastics: increased risk of hematologic toxicity
Aspirin: decreased piroxicam blood level and efficacy
Corticosteroids, other NSAIDs: additive adverse GI reactions
Diuretics, other antihypertensives: decreased response to these drugs
Insulin, oral hypoglycemics: increased risk of hypoglycemia
Lithium: increased lithium blood level and risk of toxicity
Probenecid: increased piroxicam blood level and risk of toxicity
Acetaminophen (chronic use), cyclosporine, gold compounds: increased risk of adverse renal reactions
Anticoagulants, cefamandole, cefoperazone, cefotetan, clopidogrel, eptifibatide, heparin, plicamycin, thrombolytics, ticlopidine, tirofiban, valproic acid, vitamin A: increased risk of bleeding
Antineoplastics: increased risk of hematologic toxicity
Aspirin: decreased piroxicam blood level and efficacy
Corticosteroids, other NSAIDs: additive adverse GI reactions
Diuretics, other antihypertensives: decreased response to these drugs
Insulin, oral hypoglycemics: increased risk of hypoglycemia
Lithium: increased lithium blood level and risk of toxicity
Probenecid: increased piroxicam blood level and risk of toxicity
Acetaminophen (chronic use), cyclosporine, gold compounds: increased risk of adverse renal reactions
Anticoagulants, cefamandole, cefoperazone, cefotetan, clopidogrel, eptifibatide, heparin, plicamycin, thrombolytics, ticlopidine, tirofiban, valproic acid, vitamin A: increased risk of bleeding
Antineoplastics: increased risk of hematologic toxicity
Aspirin: decreased piroxicam blood level and efficacy
Corticosteroids, other NSAIDs: additive adverse GI reactions
Diuretics, other antihypertensives: decreased response to these drugs
Insulin, oral hypoglycemics: increased risk of hypoglycemia
Lithium: increased lithium blood level and risk of toxicity
Probenecid: increased piroxicam blood level and risk of toxicity
CNS: headache, drowsiness, dizziness
CV: edema, hypertension, vasculitis, tachycardia, arrhythmias
EENT: blurred vision, tinnitus
GU: proteinuria, renal failure
Hematologic: anemia, blood dyscrasias
Hepatic: jaundice, hepatitis
Skin: rash
Other: allergic reactions including anaphylaxis
CNS: headache, drowsiness, dizziness
CV: edema, hypertension, vasculitis, tachycardia, arrhythmias
EENT: blurred vision, tinnitus
GU: proteinuria, renal failure
Hematologic: anemia, blood dyscrasias
Hepatic: jaundice, hepatitis
Skin: rash
Other: allergic reactions including anaphylaxis
CNS: headache, drowsiness, dizziness
CV: edema, hypertension, vasculitis, tachycardia, arrhythmias
EENT: blurred vision, tinnitus
GU: proteinuria, renal failure
Hematologic: anemia, blood dyscrasias
Hepatic: jaundice, hepatitis
Skin: rash
Other: allergic reactions including anaphylaxis
CNS: headache, drowsiness, dizziness
CV: edema, hypertension, vasculitis, tachycardia, arrhythmias
EENT: blurred vision, tinnitus
GU: proteinuria, renal failure
Hematologic: anemia, blood dyscrasias
Hepatic: jaundice, hepatitis
Skin: rash
Other: allergic reactions including anaphylaxis
CNS: headache, drowsiness, dizziness
CV: edema, hypertension, vasculitis, tachycardia, arrhythmias
EENT: blurred vision, tinnitus
GU: proteinuria, renal failure
Hematologic: anemia, blood dyscrasias
Hepatic: jaundice, hepatitis
Skin: rash
Other: allergic reactions including anaphylaxis
• Store below 30 C°
• Protect from light and freezing
• Store below 30 C°
• Protect from light and freezing
• Store below 30 C°
• Protect from light and freezing
• Store below 30 C°
• Protect from light and freezing
• Store below 30 C°
• Protect from light and freezing
Piroxicam injection 20mg /ml : 10 ampoules/box
Piroxicam 0.5% topical gel : 1 tube/box- 60 g
Piroxicam injection 20mg /ml : 10 ampoules/box
Piroxicam 0.5% topical gel : 1 tube/box- 60 g
Piroxicam injection 20mg /ml : 10 ampoules/box
Piroxicam 0.5% topical gel : 1 tube/box- 60 g
Piroxicam injection 20mg /ml : 10 ampoules/box
Piroxicam 0.5% topical gel : 1 tube/box- 60 g
Piroxicam injection 20mg /ml : 10 ampoules/box
Piroxicam 0.5% topical gel : 1 tube/box- 60 g
Rocamix®
0.5% Topical Gel
Non-steroidal anti-inflammatory drug (NSAID)
Analgesic, anti-inflammatory, antipyretic
category C
The mechanism of action of piroxicam, like that of other NSAIDs, is not completely understood but may be related to prostaglandin synthetase inhibition.
Distribution
The apparent volume of distribution of piroxicam is approximately 0.14L/kg. Ninety-nine percent of plasma piroxicam is bound to plasma proteins. Piroxicam is excreted into human milk. The presence in breast milk has been determined during initial and long-term conditions (52 days). Piroxicam appeared in breast milk at about 1% to 3% of the maternal concentration. No accumulation of piroxicam occurred in milk relative to that in plasma during treatment.
Metabolism
Metabolism of piroxicam occurs by hydroxylation at the 5 position of the pyridyl side chain and conjugation of this product; by cyclodehydration; and by a sequence of reactions involving hydrolysis of the amide linkage, decarboxylation, ring contraction, and N-demethylation. The biotransformation products of piroxicam metabolism are reported to not have any anti-inflammatory activity.
Excretion
Piroxicam and its biotransformation products are excreted in urine and feces, with about twice as much appearing in the urine as in the feces. Approximately 5% of a Piroxicam dose is excreted unchanged. The plasma half-life (T½) for Piroxicam is approximately 50 hours.
• osteoarthritis
• rheumatoid arthritis
• ankylosing spondylitis
• primary dysmenorrhea
• Hypersensitivity to drug or other NSAIDs (including aspirin)
• Third trimester of pregnancy
• renal impairment, severe cardiovascular or hepatic disease
• pregnant patients in first or secondtrimester
• breastfeeding patients (not recommended)
• children (safety not established).
Acetaminophen (chronic use), cyclosporine, gold compounds: increased risk of adverse renal reactions
Anticoagulants, cefamandole, cefoperazone, cefotetan, clopidogrel, eptifibatide, heparin, plicamycin, thrombolytics, ticlopidine, tirofiban, valproic acid, vitamin A: increased risk of bleeding
Antineoplastics: increased risk of hematologic toxicity
Aspirin: decreased piroxicam blood level and efficacy
Corticosteroids, other NSAIDs: additive adverse GI reactions
Diuretics, other antihypertensives: decreased response to these drugs
Insulin, oral hypoglycemics: increased risk of hypoglycemia
Lithium: increased lithium blood level and risk of toxicity
Probenecid: increased piroxicam blood level and risk of toxicity
CNS: headache, drowsiness, dizziness
CV: edema, hypertension, vasculitis, tachycardia, arrhythmias
EENT: blurred vision, tinnitus
GU: proteinuria, renal failure
Hematologic: anemia, blood dyscrasias
Hepatic: jaundice, hepatitis
Skin: rash
Other: allergic reactions including anaphylaxis
• Store below 30 C°
• Protect from light and freezing
Piroxicam injection 20mg /ml : 10 ampoules/box
Piroxicam 0.5% topical gel : 1 tube/box- 60 g
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