Methocarbamol | Caspian Tamin Pharmaceutical Company

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The mechanism of action of Methocarbamol in humans has not been established, but may be due to general central nervous system (CNS) depression. It has no direct action on the contractile mechanism of striated muscle, the motor end plate or the nerve fiber.

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Tell your doctor or pharmacist if you are taking other products that cause drowsiness including alcohol, antihistamines (such as cetirizine, diphenhydramine), drugs for sleep or anxiety (such as alprazolam, diazepam, zolpidem), other muscle relaxants, and narcotic pain relievers (such as codeine). This medication may interfere with certain laboratory tests (including VMA or 5-HIAA urine screening test), possibly causing false test results.

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Tell your doctor or pharmacist if you are taking other products that cause drowsiness including alcohol, antihistamines (such as cetirizine, diphenhydramine), drugs for sleep or anxiety (such as alprazolam, diazepam, zolpidem), other muscle relaxants, and narcotic pain relievers (such as codeine). This medication may interfere with certain laboratory tests (including VMA or 5-HIAA urine screening test), possibly causing false test results.

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Methocarbamol is indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute, painful musculoskeletal conditions.

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In healthy volunteers, the plasma clearance of Methocarbamol ranges between 0.20 and 0.80 L/h/kg, the mean plasma elimination half-life ranges between 1 and 2 hours, and the plasma protein binding ranges between 46% and 50%.

Methocarbamol is metabolized via dealkylation and hydroxylation. Conjugation of Methocarbamol also is likely. Essentially all Methocarbamol metabolites are eliminated in the urine. Small amounts of unchanged Methocarbamol also are excreted in the urine.

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In healthy volunteers, the plasma clearance of Methocarbamol ranges between 0.20 and 0.80 L/h/kg, the mean plasma elimination half-life ranges between 1 and 2 hours, and the plasma protein binding ranges between 46% and 50%.

Methocarbamol is metabolized via dealkylation and hydroxylation. Conjugation of Methocarbamol also is likely. Essentially all Methocarbamol metabolites are eliminated in the urine. Small amounts of unchanged Methocarbamol also are excreted in the urine.

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• Patients should be cautioned that Methocarbamol may cause drowsiness or dizziness, which may impair their ability to operate motor vehicles or machinery.
• Because Methocarbamol may possess a general CNS-depressant effect, patients should be cautioned about combined effects with alcohol and other CNS depressants.

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• Patients should be cautioned that Methocarbamol may cause drowsiness or dizziness, which may impair their ability to operate motor vehicles or machinery.
• Because Methocarbamol may possess a general CNS-depressant effect, patients should be cautioned about combined effects with alcohol and other CNS depressants.

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Cardiovascular:
Cardiovascular side effects have included syncope, hypotension, and bradycardia.

Nervous system:
Nervous system side effects have included dizziness, lightheadedness, vertigo, headache, drowsiness, fainting, and mild muscular incoordination. Convulsions have been reported with intravenous administration, especially in patients with a history of epilepsy.

Dermatologic:
Dermatologic side effects have included urticaria, pruritus, rash, sloughing, thrombophlebitis, and pain at the injection site.

Ocular:
Ocular side effects have included blurred vision, conjunctivitis, nystagmus, and diplopia.

Respiratory:
Respiratory side effects have included nasal congestion, bronchospasm, and anaphylaxis.

Gastrointestinal:
Gastrointestinal side effects have included gastrointestinal upset, anorexia, and adynamic ileus.

Other:
Other side effects have included metallic taste and fever.

Effects on lab tests have included a possible color interference in certain screening tests for 5-hydroxyindoleacetic acid (5-HIAA) and vanillylmandelic acid (VMA).

Hematologic:
Hematologic side effects have included hemolysis, particularly with intravenous injection.

Renal:
Larger amounts of PEG 300 can increase preexisting renal acidosis and urea retention in patients with renal insufficiency.
Renal side effects including urine discoloration (black, blue, brown, or green) have been reported after oral administration in some patients.

General:
General side effects have included angioneurotic edema.

[view] =>

Cardiovascular:
Cardiovascular side effects have included syncope, hypotension, and bradycardia.

Nervous system:
Nervous system side effects have included dizziness, lightheadedness, vertigo, headache, drowsiness, fainting, and mild muscular incoordination. Convulsions have been reported with intravenous administration, especially in patients with a history of epilepsy.

Dermatologic:
Dermatologic side effects have included urticaria, pruritus, rash, sloughing, thrombophlebitis, and pain at the injection site.

Ocular:
Ocular side effects have included blurred vision, conjunctivitis, nystagmus, and diplopia.

Respiratory:
Respiratory side effects have included nasal congestion, bronchospasm, and anaphylaxis.

Gastrointestinal:
Gastrointestinal side effects have included gastrointestinal upset, anorexia, and adynamic ileus.

Other:
Other side effects have included metallic taste and fever.

Effects on lab tests have included a possible color interference in certain screening tests for 5-hydroxyindoleacetic acid (5-HIAA) and vanillylmandelic acid (VMA).

Hematologic:
Hematologic side effects have included hemolysis, particularly with intravenous injection.

Renal:
Larger amounts of PEG 300 can increase preexisting renal acidosis and urea retention in patients with renal insufficiency.
Renal side effects including urine discoloration (black, blue, brown, or green) have been reported after oral administration in some patients.

General:
General side effects have included angioneurotic edema.

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The mechanism of action of Methocarbamol in humans has not been established, but may be due to general central nervous system (CNS) depression. It has no direct action on the contractile mechanism of striated muscle, the motor end plate or the nerve fiber.

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In healthy volunteers, the plasma clearance of Methocarbamol ranges between 0.20 and 0.80 L/h/kg, the mean plasma elimination half-life ranges between 1 and 2 hours, and the plasma protein binding ranges between 46% and 50%.

Methocarbamol is metabolized via dealkylation and hydroxylation. Conjugation of Methocarbamol also is likely. Essentially all Methocarbamol metabolites are eliminated in the urine. Small amounts of unchanged Methocarbamol also are excreted in the urine.

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In healthy volunteers, the plasma clearance of Methocarbamol ranges between 0.20 and 0.80 L/h/kg, the mean plasma elimination half-life ranges between 1 and 2 hours, and the plasma protein binding ranges between 46% and 50%.

Methocarbamol is metabolized via dealkylation and hydroxylation. Conjugation of Methocarbamol also is likely. Essentially all Methocarbamol metabolites are eliminated in the urine. Small amounts of unchanged Methocarbamol also are excreted in the urine.

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In healthy volunteers, the plasma clearance of Methocarbamol ranges between 0.20 and 0.80 L/h/kg, the mean plasma elimination half-life ranges between 1 and 2 hours, and the plasma protein binding ranges between 46% and 50%.

Methocarbamol is metabolized via dealkylation and hydroxylation. Conjugation of Methocarbamol also is likely. Essentially all Methocarbamol metabolites are eliminated in the urine. Small amounts of unchanged Methocarbamol also are excreted in the urine.

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In healthy volunteers, the plasma clearance of Methocarbamol ranges between 0.20 and 0.80 L/h/kg, the mean plasma elimination half-life ranges between 1 and 2 hours, and the plasma protein binding ranges between 46% and 50%.

Methocarbamol is metabolized via dealkylation and hydroxylation. Conjugation of Methocarbamol also is likely. Essentially all Methocarbamol metabolites are eliminated in the urine. Small amounts of unchanged Methocarbamol also are excreted in the urine.

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Methocarbamol is indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute, painful musculoskeletal conditions.

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Methocarbamol is indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute, painful musculoskeletal conditions.

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Methocarbamol is indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute, painful musculoskeletal conditions.

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Methocarbamol is indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute, painful musculoskeletal conditions.

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• Methocarbamol is contraindicated in patients hypersensitive to Methocarbamol or to any of the ampoule components.

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• Methocarbamol is contraindicated in patients hypersensitive to Methocarbamol or to any of the ampoule components.

) [#title] => [#description] => [#children] =>

• Methocarbamol is contraindicated in patients hypersensitive to Methocarbamol or to any of the ampoule components.

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• Methocarbamol is contraindicated in patients hypersensitive to Methocarbamol or to any of the ampoule components.

[#printed] => 1 ) [#title] => [#description] => [#children] => [#printed] => 1 ) [field_precautions] => Array ( [#type_name] => product [#context] => full [#field_name] => field_precautions [#post_render] => Array ( [0] => content_field_wrapper_post_render ) [#weight] => 8 [field] => Array ( [#description] => [items] => Array ( [0] => Array ( [#formatter] => default [#node] => stdClass Object *RECURSION* [#type_name] => product [#field_name] => field_precautions [#weight] => 0 [#theme] => text_formatter_default [#item] => Array ( [value] => • Patients should be cautioned that Methocarbamol may cause drowsiness or dizziness, which may impair their ability to operate motor vehicles or machinery. • Because Methocarbamol may possess a general CNS-depressant effect, patients should be cautioned about combined effects with alcohol and other CNS depressants. [format] => 1 [safe] =>

• Patients should be cautioned that Methocarbamol may cause drowsiness or dizziness, which may impair their ability to operate motor vehicles or machinery.
• Because Methocarbamol may possess a general CNS-depressant effect, patients should be cautioned about combined effects with alcohol and other CNS depressants.

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• Patients should be cautioned that Methocarbamol may cause drowsiness or dizziness, which may impair their ability to operate motor vehicles or machinery.
• Because Methocarbamol may possess a general CNS-depressant effect, patients should be cautioned about combined effects with alcohol and other CNS depressants.

) [#title] => [#description] => [#children] =>

• Patients should be cautioned that Methocarbamol may cause drowsiness or dizziness, which may impair their ability to operate motor vehicles or machinery.
• Because Methocarbamol may possess a general CNS-depressant effect, patients should be cautioned about combined effects with alcohol and other CNS depressants.

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• Patients should be cautioned that Methocarbamol may cause drowsiness or dizziness, which may impair their ability to operate motor vehicles or machinery.
• Because Methocarbamol may possess a general CNS-depressant effect, patients should be cautioned about combined effects with alcohol and other CNS depressants.

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Tell your doctor or pharmacist if you are taking other products that cause drowsiness including alcohol, antihistamines (such as cetirizine, diphenhydramine), drugs for sleep or anxiety (such as alprazolam, diazepam, zolpidem), other muscle relaxants, and narcotic pain relievers (such as codeine). This medication may interfere with certain laboratory tests (including VMA or 5-HIAA urine screening test), possibly causing false test results.

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Tell your doctor or pharmacist if you are taking other products that cause drowsiness including alcohol, antihistamines (such as cetirizine, diphenhydramine), drugs for sleep or anxiety (such as alprazolam, diazepam, zolpidem), other muscle relaxants, and narcotic pain relievers (such as codeine). This medication may interfere with certain laboratory tests (including VMA or 5-HIAA urine screening test), possibly causing false test results.

) [#title] => [#description] => [#children] =>

Tell your doctor or pharmacist if you are taking other products that cause drowsiness including alcohol, antihistamines (such as cetirizine, diphenhydramine), drugs for sleep or anxiety (such as alprazolam, diazepam, zolpidem), other muscle relaxants, and narcotic pain relievers (such as codeine). This medication may interfere with certain laboratory tests (including VMA or 5-HIAA urine screening test), possibly causing false test results.

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Tell your doctor or pharmacist if you are taking other products that cause drowsiness including alcohol, antihistamines (such as cetirizine, diphenhydramine), drugs for sleep or anxiety (such as alprazolam, diazepam, zolpidem), other muscle relaxants, and narcotic pain relievers (such as codeine). This medication may interfere with certain laboratory tests (including VMA or 5-HIAA urine screening test), possibly causing false test results.

[#printed] => 1 ) [#title] => [#description] => [#children] => [#printed] => 1 ) [field_side_effects] => Array ( [#type_name] => product [#context] => full [#field_name] => field_side_effects [#post_render] => Array ( [0] => content_field_wrapper_post_render ) [#weight] => 10 [field] => Array ( [#description] => [items] => Array ( [0] => Array ( [#formatter] => default [#node] => stdClass Object *RECURSION* [#type_name] => product [#field_name] => field_side_effects [#weight] => 0 [#theme] => text_formatter_default [#item] => Array ( [value] => Cardiovascular: Cardiovascular side effects have included syncope, hypotension, and bradycardia. Nervous system: Nervous system side effects have included dizziness, lightheadedness, vertigo, headache, drowsiness, fainting, and mild muscular incoordination. Convulsions have been reported with intravenous administration, especially in patients with a history of epilepsy. Dermatologic: Dermatologic side effects have included urticaria, pruritus, rash, sloughing, thrombophlebitis, and pain at the injection site. Ocular: Ocular side effects have included blurred vision, conjunctivitis, nystagmus, and diplopia. Respiratory: Respiratory side effects have included nasal congestion, bronchospasm, and anaphylaxis. Gastrointestinal: Gastrointestinal side effects have included gastrointestinal upset, anorexia, and adynamic ileus. Other: Other side effects have included metallic taste and fever. Effects on lab tests have included a possible color interference in certain screening tests for 5-hydroxyindoleacetic acid (5-HIAA) and vanillylmandelic acid (VMA). Hematologic: Hematologic side effects have included hemolysis, particularly with intravenous injection. Renal: Larger amounts of PEG 300 can increase preexisting renal acidosis and urea retention in patients with renal insufficiency. Renal side effects including urine discoloration (black, blue, brown, or green) have been reported after oral administration in some patients. General: General side effects have included angioneurotic edema. [format] => 1 [safe] =>

Cardiovascular:
Cardiovascular side effects have included syncope, hypotension, and bradycardia.

Nervous system:
Nervous system side effects have included dizziness, lightheadedness, vertigo, headache, drowsiness, fainting, and mild muscular incoordination. Convulsions have been reported with intravenous administration, especially in patients with a history of epilepsy.

Dermatologic:
Dermatologic side effects have included urticaria, pruritus, rash, sloughing, thrombophlebitis, and pain at the injection site.

Ocular:
Ocular side effects have included blurred vision, conjunctivitis, nystagmus, and diplopia.

Respiratory:
Respiratory side effects have included nasal congestion, bronchospasm, and anaphylaxis.

Gastrointestinal:
Gastrointestinal side effects have included gastrointestinal upset, anorexia, and adynamic ileus.

Other:
Other side effects have included metallic taste and fever.

Effects on lab tests have included a possible color interference in certain screening tests for 5-hydroxyindoleacetic acid (5-HIAA) and vanillylmandelic acid (VMA).

Hematologic:
Hematologic side effects have included hemolysis, particularly with intravenous injection.

Renal:
Larger amounts of PEG 300 can increase preexisting renal acidosis and urea retention in patients with renal insufficiency.
Renal side effects including urine discoloration (black, blue, brown, or green) have been reported after oral administration in some patients.

General:
General side effects have included angioneurotic edema.

[#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] =>

Cardiovascular:
Cardiovascular side effects have included syncope, hypotension, and bradycardia.

Nervous system:
Nervous system side effects have included dizziness, lightheadedness, vertigo, headache, drowsiness, fainting, and mild muscular incoordination. Convulsions have been reported with intravenous administration, especially in patients with a history of epilepsy.

Dermatologic:
Dermatologic side effects have included urticaria, pruritus, rash, sloughing, thrombophlebitis, and pain at the injection site.

Ocular:
Ocular side effects have included blurred vision, conjunctivitis, nystagmus, and diplopia.

Respiratory:
Respiratory side effects have included nasal congestion, bronchospasm, and anaphylaxis.

Gastrointestinal:
Gastrointestinal side effects have included gastrointestinal upset, anorexia, and adynamic ileus.

Other:
Other side effects have included metallic taste and fever.

Effects on lab tests have included a possible color interference in certain screening tests for 5-hydroxyindoleacetic acid (5-HIAA) and vanillylmandelic acid (VMA).

Hematologic:
Hematologic side effects have included hemolysis, particularly with intravenous injection.

Renal:
Larger amounts of PEG 300 can increase preexisting renal acidosis and urea retention in patients with renal insufficiency.
Renal side effects including urine discoloration (black, blue, brown, or green) have been reported after oral administration in some patients.

General:
General side effects have included angioneurotic edema.

) [#title] => [#description] => [#children] =>

Cardiovascular:
Cardiovascular side effects have included syncope, hypotension, and bradycardia.

Nervous system:
Nervous system side effects have included dizziness, lightheadedness, vertigo, headache, drowsiness, fainting, and mild muscular incoordination. Convulsions have been reported with intravenous administration, especially in patients with a history of epilepsy.

Dermatologic:
Dermatologic side effects have included urticaria, pruritus, rash, sloughing, thrombophlebitis, and pain at the injection site.

Ocular:
Ocular side effects have included blurred vision, conjunctivitis, nystagmus, and diplopia.

Respiratory:
Respiratory side effects have included nasal congestion, bronchospasm, and anaphylaxis.

Gastrointestinal:
Gastrointestinal side effects have included gastrointestinal upset, anorexia, and adynamic ileus.

Other:
Other side effects have included metallic taste and fever.

Effects on lab tests have included a possible color interference in certain screening tests for 5-hydroxyindoleacetic acid (5-HIAA) and vanillylmandelic acid (VMA).

Hematologic:
Hematologic side effects have included hemolysis, particularly with intravenous injection.

Renal:
Larger amounts of PEG 300 can increase preexisting renal acidosis and urea retention in patients with renal insufficiency.
Renal side effects including urine discoloration (black, blue, brown, or green) have been reported after oral administration in some patients.

General:
General side effects have included angioneurotic edema.

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Cardiovascular:
Cardiovascular side effects have included syncope, hypotension, and bradycardia.

Nervous system:
Nervous system side effects have included dizziness, lightheadedness, vertigo, headache, drowsiness, fainting, and mild muscular incoordination. Convulsions have been reported with intravenous administration, especially in patients with a history of epilepsy.

Dermatologic:
Dermatologic side effects have included urticaria, pruritus, rash, sloughing, thrombophlebitis, and pain at the injection site.

Ocular:
Ocular side effects have included blurred vision, conjunctivitis, nystagmus, and diplopia.

Respiratory:
Respiratory side effects have included nasal congestion, bronchospasm, and anaphylaxis.

Gastrointestinal:
Gastrointestinal side effects have included gastrointestinal upset, anorexia, and adynamic ileus.

Other:
Other side effects have included metallic taste and fever.

Effects on lab tests have included a possible color interference in certain screening tests for 5-hydroxyindoleacetic acid (5-HIAA) and vanillylmandelic acid (VMA).

Hematologic:
Hematologic side effects have included hemolysis, particularly with intravenous injection.

Renal:
Larger amounts of PEG 300 can increase preexisting renal acidosis and urea retention in patients with renal insufficiency.
Renal side effects including urine discoloration (black, blue, brown, or green) have been reported after oral administration in some patients.

General:
General side effects have included angioneurotic edema.

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• Store below 30 C°
• Protect from light and freezing

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• Store below 30 C°
• Protect from light and freezing

) [#title] => [#description] => [#children] =>

• Store below 30 C°
• Protect from light and freezing

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• Store below 30 C°
• Protect from light and freezing

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• Injection 1G/10ml: 5 Ampoules/box

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• Injection 1G/10ml: 5 Ampoules/box

) [#title] => [#description] => [#children] =>

• Injection 1G/10ml: 5 Ampoules/box

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• Injection 1G/10ml: 5 Ampoules/box

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The mechanism of action of Methocarbamol in humans has not been established, but may be due to general central nervous system (CNS) depression. It has no direct action on the contractile mechanism of striated muscle, the motor end plate or the nerve fiber.

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