facilitation of the action of gamma aminobutyric acid (GABA), an inhibitory neurotransmitter in the central nervous system.
Absorption:
Apparently well absorbed following oral administration.
Absorption is slow and erratic following IM administration.
Rapidly and well absorbed following rectal administration as gel or solution; bioavailability averages 80–102%. Peak plasma concentrations attained within 1.5 hours following rectal administration of the gel in adults; absorption from gel may be more rapid in children.
Onset
Onset of anticonvulsant, anxiolytic, or sedative action occurs in 1–5 minutes following IV administration.
Duration
Duration of anticonvulsant, anxiolytic, or sedative action is 15–60 minutes following IV administration.
Distribution:
Apparently widely distributed into body tissues; crosses the blood-brain barrier.
Diazepam and its metabolites cross the placenta and are distributed into milk.
Plasma Protein Binding:
Diazepam and desmethyldiazepam: 95–98%.
Elimination:
Metabolized in the liver by CYP2C19 and CYP3A4 to active metabolites.
Excreted principally in urine as inactive conjugates.
Half-life:
Diazepam: 20–50 hours.
Metabolites: Desmethyldiazepam: 30–200 hours. Temazepam: 5–20 hours. Oxazepam: 3–21 hours.
treat anxiety disorders, alcohol withdrawal symptoms, or muscle spasms. Diazepam is sometimes used with other medications to treat seizures.
Diazepam is contraindicated in patients with a known hypersensitivity to this drug; acute narrow angle glaucoma; and open angle glaucoma unless patients are receiving appropriate therapy.
Although seizures may be brought under control promptly, a significant proportion of patients experience a return to seizure activity, presumably due to the short-lived effect of diazepam after I.V. administration. The physician should be prepared to re-administer the drug. However, diazepam is not recommended for maintenance, and once seizures are brought under control, consideration should be given to the administration of agents useful in longer term control of seizures. Diazepam Injection has produced hypotension or muscular weakness in some patients particularly when used with narcotics, barbiturates or alcohol. Lower doses (usually 2 mg to 5 mg) should be used for elderly and debilitated patients.
• cimetidine;
• omeprazole;
• phenytoin;
• an antibiotic--clarithromycin, erythromycin, telithromycin;
• an antidepressant such as fluoxetine, fluoxetine, and others;
• antifungal medicine--itraconazole, ketoconazole, voriconazole;
• heart or blood pressure medication such as diltiazem, nicardipine, quinidine, verapamil, and others; or
• HIV/AIDS medicine--atazanavir, delavirdine, fosamprenavir, indinavir, nelfinavir, saquinavir, or ritonavir.
• confusion, hallucinations, unusual thoughts or behavior;
• unusual risk-taking behavior, decreased inhibitions, no fear of danger;
• depressed mood, thoughts of suicide or hurting yourself;
• hyperactivity, agitation, aggression, hostility;
• new or worsening seizures;
• weak or shallow breathing;
• a feeling like you might pass out;
• muscle twitching, tremor;
• loss of bladder control; or
• little or no urinating.
Common diazepam side effects may include:
• memory problems;
• drowsiness, tired feeling;
• dizziness, spinning sensation;
• feeling restless or irritable;
• muscle weakness;
• nausea, constipation;
• drooling or dry mouth, slurred speech;
• blurred vision, double vision;
• mild skin rash, itching; or
• loss of interest in sex.
• Store below 30 C°
• Protect from light and freezing
• Injection 10mg/2ml: Box of 10,100 Ampoules
ZEPADIC®
Injection 10mg/2ml
Benzodiazepines
Anxiolytic,Sedative,Hypnotic Anticonvulsant and Antipsychotic
Category D
facilitation of the action of gamma aminobutyric acid (GABA), an inhibitory neurotransmitter in the central nervous system.
Absorption:
Apparently well absorbed following oral administration.
Absorption is slow and erratic following IM administration.
Rapidly and well absorbed following rectal administration as gel or solution; bioavailability averages 80–102%. Peak plasma concentrations attained within 1.5 hours following rectal administration of the gel in adults; absorption from gel may be more rapid in children.
Onset
Onset of anticonvulsant, anxiolytic, or sedative action occurs in 1–5 minutes following IV administration.
Duration
Duration of anticonvulsant, anxiolytic, or sedative action is 15–60 minutes following IV administration.
Distribution:
Apparently widely distributed into body tissues; crosses the blood-brain barrier.
Diazepam and its metabolites cross the placenta and are distributed into milk.
Plasma Protein Binding:
Diazepam and desmethyldiazepam: 95–98%.
Elimination:
Metabolized in the liver by CYP2C19 and CYP3A4 to active metabolites.
Excreted principally in urine as inactive conjugates.
Half-life:
Diazepam: 20–50 hours.
Metabolites: Desmethyldiazepam: 30–200 hours. Temazepam: 5–20 hours. Oxazepam: 3–21 hours.
treat anxiety disorders, alcohol withdrawal symptoms, or muscle spasms. Diazepam is sometimes used with other medications to treat seizures.
Diazepam is contraindicated in patients with a known hypersensitivity to this drug; acute narrow angle glaucoma; and open angle glaucoma unless patients are receiving appropriate therapy.
Although seizures may be brought under control promptly, a significant proportion of patients experience a return to seizure activity, presumably due to the short-lived effect of diazepam after I.V. administration. The physician should be prepared to re-administer the drug. However, diazepam is not recommended for maintenance, and once seizures are brought under control, consideration should be given to the administration of agents useful in longer term control of seizures. Diazepam Injection has produced hypotension or muscular weakness in some patients particularly when used with narcotics, barbiturates or alcohol. Lower doses (usually 2 mg to 5 mg) should be used for elderly and debilitated patients.
• cimetidine;
• omeprazole;
• phenytoin;
• an antibiotic--clarithromycin, erythromycin, telithromycin;
• an antidepressant such as fluoxetine, fluoxetine, and others;
• antifungal medicine--itraconazole, ketoconazole, voriconazole;
• heart or blood pressure medication such as diltiazem, nicardipine, quinidine, verapamil, and others; or
• HIV/AIDS medicine--atazanavir, delavirdine, fosamprenavir, indinavir, nelfinavir, saquinavir, or ritonavir.
• confusion, hallucinations, unusual thoughts or behavior;
• unusual risk-taking behavior, decreased inhibitions, no fear of danger;
• depressed mood, thoughts of suicide or hurting yourself;
• hyperactivity, agitation, aggression, hostility;
• new or worsening seizures;
• weak or shallow breathing;
• a feeling like you might pass out;
• muscle twitching, tremor;
• loss of bladder control; or
• little or no urinating.
Common diazepam side effects may include:
• memory problems;
• drowsiness, tired feeling;
• dizziness, spinning sensation;
• feeling restless or irritable;
• muscle weakness;
• nausea, constipation;
• drooling or dry mouth, slurred speech;
• blurred vision, double vision;
• mild skin rash, itching; or
• loss of interest in sex.
• Store below 30 C°
• Protect from light and freezing
• Injection 10mg/2ml: Box of 10,100 Ampoules
ZEPADIC®
[view] =>ZEPADIC®
) ) [field_contraindications] => Array ( [0] => Array ( [value] => Diazepam is contraindicated in patients with a known hypersensitivity to this drug; acute narrow angle glaucoma; and open angle glaucoma unless patients are receiving appropriate therapy. [format] => 1 [safe] =>Diazepam is contraindicated in patients with a known hypersensitivity to this drug; acute narrow angle glaucoma; and open angle glaucoma unless patients are receiving appropriate therapy.
[view] =>Diazepam is contraindicated in patients with a known hypersensitivity to this drug; acute narrow angle glaucoma; and open angle glaucoma unless patients are receiving appropriate therapy.
) ) [field_dosage_form] => Array ( [0] => Array ( [value] => Injection 10mg/2ml [format] => 1 [safe] =>Injection 10mg/2ml
[view] =>Injection 10mg/2ml
) ) [field_drug_interactions] => Array ( [0] => Array ( [value] => • cimetidine; • omeprazole; • phenytoin; • an antibiotic--clarithromycin, erythromycin, telithromycin; • an antidepressant such as fluoxetine, fluoxetine, and others; • antifungal medicine--itraconazole, ketoconazole, voriconazole; • heart or blood pressure medication such as diltiazem, nicardipine, quinidine, verapamil, and others; or • HIV/AIDS medicine--atazanavir, delavirdine, fosamprenavir, indinavir, nelfinavir, saquinavir, or ritonavir. [format] => 1 [safe] =>• cimetidine;
• omeprazole;
• phenytoin;
• an antibiotic--clarithromycin, erythromycin, telithromycin;
• an antidepressant such as fluoxetine, fluoxetine, and others;
• antifungal medicine--itraconazole, ketoconazole, voriconazole;
• heart or blood pressure medication such as diltiazem, nicardipine, quinidine, verapamil, and others; or
• HIV/AIDS medicine--atazanavir, delavirdine, fosamprenavir, indinavir, nelfinavir, saquinavir, or ritonavir.
• cimetidine;
• omeprazole;
• phenytoin;
• an antibiotic--clarithromycin, erythromycin, telithromycin;
• an antidepressant such as fluoxetine, fluoxetine, and others;
• antifungal medicine--itraconazole, ketoconazole, voriconazole;
• heart or blood pressure medication such as diltiazem, nicardipine, quinidine, verapamil, and others; or
• HIV/AIDS medicine--atazanavir, delavirdine, fosamprenavir, indinavir, nelfinavir, saquinavir, or ritonavir.
treat anxiety disorders, alcohol withdrawal symptoms, or muscle spasms. Diazepam is sometimes used with other medications to treat seizures.
[view] =>treat anxiety disorders, alcohol withdrawal symptoms, or muscle spasms. Diazepam is sometimes used with other medications to treat seizures.
) ) [field_packing] => Array ( [0] => Array ( [value] => • Injection 10mg/2ml: Box of 10,100 Ampoules [format] => 1 [safe] =>• Injection 10mg/2ml: Box of 10,100 Ampoules
[view] =>• Injection 10mg/2ml: Box of 10,100 Ampoules
) ) [field_pdf] => Array ( [0] => Array ( [fid] => 183 [uid] => 1 [filename] => diazepam.pdf [filepath] => sites/default/files/pdf/diazepam.pdf [filemime] => application/pdf [filesize] => 141708 [status] => 1 [timestamp] => 1329488923 [list] => 1 [data] => [i18nsync] => 1 [nid] => 273 [view] => ) ) [field_pharmacokinetics] => Array ( [0] => Array ( [value] => Absorption: Apparently well absorbed following oral administration. Absorption is slow and erratic following IM administration. Rapidly and well absorbed following rectal administration as gel or solution; bioavailability averages 80–102%. Peak plasma concentrations attained within 1.5 hours following rectal administration of the gel in adults; absorption from gel may be more rapid in children. Onset Onset of anticonvulsant, anxiolytic, or sedative action occurs in 1–5 minutes following IV administration. Duration Duration of anticonvulsant, anxiolytic, or sedative action is 15–60 minutes following IV administration. Distribution: Apparently widely distributed into body tissues; crosses the blood-brain barrier. Diazepam and its metabolites cross the placenta and are distributed into milk. Plasma Protein Binding: Diazepam and desmethyldiazepam: 95–98%. Elimination: Metabolized in the liver by CYP2C19 and CYP3A4 to active metabolites. Excreted principally in urine as inactive conjugates. Half-life: Diazepam: 20–50 hours. Metabolites: Desmethyldiazepam: 30–200 hours. Temazepam: 5–20 hours. Oxazepam: 3–21 hours. [format] => 1 [safe] =>Absorption:
Apparently well absorbed following oral administration.
Absorption is slow and erratic following IM administration.
Rapidly and well absorbed following rectal administration as gel or solution; bioavailability averages 80–102%. Peak plasma concentrations attained within 1.5 hours following rectal administration of the gel in adults; absorption from gel may be more rapid in children.
Onset
Onset of anticonvulsant, anxiolytic, or sedative action occurs in 1–5 minutes following IV administration.
Duration
Duration of anticonvulsant, anxiolytic, or sedative action is 15–60 minutes following IV administration.
Distribution:
Apparently widely distributed into body tissues; crosses the blood-brain barrier.
Diazepam and its metabolites cross the placenta and are distributed into milk.
Plasma Protein Binding:
Diazepam and desmethyldiazepam: 95–98%.
Elimination:
Metabolized in the liver by CYP2C19 and CYP3A4 to active metabolites.
Excreted principally in urine as inactive conjugates.
Half-life:
Diazepam: 20–50 hours.
Metabolites: Desmethyldiazepam: 30–200 hours. Temazepam: 5–20 hours. Oxazepam: 3–21 hours.
Absorption:
Apparently well absorbed following oral administration.
Absorption is slow and erratic following IM administration.
Rapidly and well absorbed following rectal administration as gel or solution; bioavailability averages 80–102%. Peak plasma concentrations attained within 1.5 hours following rectal administration of the gel in adults; absorption from gel may be more rapid in children.
Onset
Onset of anticonvulsant, anxiolytic, or sedative action occurs in 1–5 minutes following IV administration.
Duration
Duration of anticonvulsant, anxiolytic, or sedative action is 15–60 minutes following IV administration.
Distribution:
Apparently widely distributed into body tissues; crosses the blood-brain barrier.
Diazepam and its metabolites cross the placenta and are distributed into milk.
Plasma Protein Binding:
Diazepam and desmethyldiazepam: 95–98%.
Elimination:
Metabolized in the liver by CYP2C19 and CYP3A4 to active metabolites.
Excreted principally in urine as inactive conjugates.
Half-life:
Diazepam: 20–50 hours.
Metabolites: Desmethyldiazepam: 30–200 hours. Temazepam: 5–20 hours. Oxazepam: 3–21 hours.
Benzodiazepines
[view] =>Benzodiazepines
) ) [field_precautions] => Array ( [0] => Array ( [value] => Although seizures may be brought under control promptly, a significant proportion of patients experience a return to seizure activity, presumably due to the short-lived effect of diazepam after I.V. administration. The physician should be prepared to re-administer the drug. However, diazepam is not recommended for maintenance, and once seizures are brought under control, consideration should be given to the administration of agents useful in longer term control of seizures. Diazepam Injection has produced hypotension or muscular weakness in some patients particularly when used with narcotics, barbiturates or alcohol. Lower doses (usually 2 mg to 5 mg) should be used for elderly and debilitated patients. [format] => 1 [safe] =>Although seizures may be brought under control promptly, a significant proportion of patients experience a return to seizure activity, presumably due to the short-lived effect of diazepam after I.V. administration. The physician should be prepared to re-administer the drug. However, diazepam is not recommended for maintenance, and once seizures are brought under control, consideration should be given to the administration of agents useful in longer term control of seizures. Diazepam Injection has produced hypotension or muscular weakness in some patients particularly when used with narcotics, barbiturates or alcohol. Lower doses (usually 2 mg to 5 mg) should be used for elderly and debilitated patients.
[view] =>Although seizures may be brought under control promptly, a significant proportion of patients experience a return to seizure activity, presumably due to the short-lived effect of diazepam after I.V. administration. The physician should be prepared to re-administer the drug. However, diazepam is not recommended for maintenance, and once seizures are brought under control, consideration should be given to the administration of agents useful in longer term control of seizures. Diazepam Injection has produced hypotension or muscular weakness in some patients particularly when used with narcotics, barbiturates or alcohol. Lower doses (usually 2 mg to 5 mg) should be used for elderly and debilitated patients.
) ) [field_pregnancy_category] => Array ( [0] => Array ( [value] => Category D [format] => 1 [safe] =>Category D
[view] =>Category D
) ) [field_references] => Array ( [0] => Array ( [value] => [format] => [safe] => [view] => ) ) [field_side_effects] => Array ( [0] => Array ( [value] => • confusion, hallucinations, unusual thoughts or behavior; • unusual risk-taking behavior, decreased inhibitions, no fear of danger; • depressed mood, thoughts of suicide or hurting yourself; • hyperactivity, agitation, aggression, hostility; • new or worsening seizures; • weak or shallow breathing; • a feeling like you might pass out; • muscle twitching, tremor; • loss of bladder control; or • little or no urinating. Common diazepam side effects may include: • memory problems; • drowsiness, tired feeling; • dizziness, spinning sensation; • feeling restless or irritable; • muscle weakness; • nausea, constipation; • drooling or dry mouth, slurred speech; • blurred vision, double vision; • mild skin rash, itching; or • loss of interest in sex. [format] => 1 [safe] =>• confusion, hallucinations, unusual thoughts or behavior;
• unusual risk-taking behavior, decreased inhibitions, no fear of danger;
• depressed mood, thoughts of suicide or hurting yourself;
• hyperactivity, agitation, aggression, hostility;
• new or worsening seizures;
• weak or shallow breathing;
• a feeling like you might pass out;
• muscle twitching, tremor;
• loss of bladder control; or
• little or no urinating.
Common diazepam side effects may include:
• memory problems;
• drowsiness, tired feeling;
• dizziness, spinning sensation;
• feeling restless or irritable;
• muscle weakness;
• nausea, constipation;
• drooling or dry mouth, slurred speech;
• blurred vision, double vision;
• mild skin rash, itching; or
• loss of interest in sex.
• confusion, hallucinations, unusual thoughts or behavior;
• unusual risk-taking behavior, decreased inhibitions, no fear of danger;
• depressed mood, thoughts of suicide or hurting yourself;
• hyperactivity, agitation, aggression, hostility;
• new or worsening seizures;
• weak or shallow breathing;
• a feeling like you might pass out;
• muscle twitching, tremor;
• loss of bladder control; or
• little or no urinating.
Common diazepam side effects may include:
• memory problems;
• drowsiness, tired feeling;
• dizziness, spinning sensation;
• feeling restless or irritable;
• muscle weakness;
• nausea, constipation;
• drooling or dry mouth, slurred speech;
• blurred vision, double vision;
• mild skin rash, itching; or
• loss of interest in sex.
• Store below 30 C°
• Protect from light and freezing
• Store below 30 C°
• Protect from light and freezing
Anxiolytic,Sedative,Hypnotic Anticonvulsant and Antipsychotic
[view] =>Anxiolytic,Sedative,Hypnotic Anticonvulsant and Antipsychotic
) ) [field_related_products] => Array ( [0] => Array ( [nid] => [i18nsync] => 1 [safe] => Array ( ) [view] => ) [1] => Array ( [nid] => [i18nsync] => 1 [safe] => Array ( ) [view] => ) [2] => Array ( [nid] => [i18nsync] => 1 [safe] => Array ( ) [view] => ) ) [taxonomy] => Array ( [4] => stdClass Object ( [tid] => 4 [vid] => 1 [name] => Antiparkinson Drugs, Antidepressants,Antiepileptics, Anxiolytic Sedative, Hypnotics and Antipsychotics [description] => [weight] => 2 [language] => [trid] => 0 [v_weight_unused] => 0 ) ) [build_mode] => 0 [readmore] => [content] => Array ( [field_one_image] => Array ( [#type_name] => product [#context] => full [#field_name] => field_one_image [#post_render] => Array ( [0] => content_field_wrapper_post_render ) [#weight] => -3 [field] => Array ( [#description] => [items] => Array ( [0] => Array ( [#formatter] => image_plain [#node] => stdClass Object *RECURSION* [#type_name] => product [#field_name] => field_one_image [#weight] => 0 [#theme] => imagefield_formatter_image_plain [#item] => Array ( [fid] => 182 [uid] => 1 [filename] => diazepam_s.jpg [filepath] => sites/default/files/images/diazepam_s.jpg [filemime] => image/jpeg [filesize] => 54910 [status] => 1 [timestamp] => 1329488470 [list] => 1 [data] => Array ( [alt] => [title] => ) [i18nsync] => 1 [nid] => 273 [#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] => ) [#title] => [#description] => [#children] => [#printed] => 1 ) [#single] => 1 [#attributes] => Array ( ) [#required] => [#parents] => Array ( ) [#tree] => [#context] => full [#page] => 1 [#field_name] => field_one_image [#title] => Image [#access] => 1 [#label_display] => above [#teaser] => [#node] => stdClass Object *RECURSION* [#type] => content_field [#children] => [#printed] => 1 ) [#title] => [#description] => [#children] =>ZEPADIC®
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) [#title] => [#description] => [#children] =>ZEPADIC®
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[#printed] => 1 ) [#title] => [#description] => [#children] =>ZEPADIC®
Injection 10mg/2ml
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) [#title] => [#description] => [#children] =>Injection 10mg/2ml
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[#printed] => 1 ) [#title] => [#description] => [#children] =>Injection 10mg/2ml
Benzodiazepines
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[#printed] => 1 ) [#title] => [#description] => [#children] =>Benzodiazepines
Anxiolytic,Sedative,Hypnotic Anticonvulsant and Antipsychotic
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[#printed] => 1 ) [#title] => [#description] => [#children] =>Anxiolytic,Sedative,Hypnotic Anticonvulsant and Antipsychotic
Category D
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[#printed] => 1 ) [#title] => [#description] => [#children] =>Category D
facilitation of the action of gamma aminobutyric acid (GABA), an inhibitory neurotransmitter in the central nervous system.
[#title] => [#description] => [#printed] => 1 ) [field_pharmacokinetics] => Array ( [#type_name] => product [#context] => full [#field_name] => field_pharmacokinetics [#post_render] => Array ( [0] => content_field_wrapper_post_render ) [#weight] => 4 [field] => Array ( [#description] => [items] => Array ( [0] => Array ( [#formatter] => default [#node] => stdClass Object *RECURSION* [#type_name] => product [#field_name] => field_pharmacokinetics [#weight] => 0 [#theme] => text_formatter_default [#item] => Array ( [value] => Absorption: Apparently well absorbed following oral administration. Absorption is slow and erratic following IM administration. Rapidly and well absorbed following rectal administration as gel or solution; bioavailability averages 80–102%. Peak plasma concentrations attained within 1.5 hours following rectal administration of the gel in adults; absorption from gel may be more rapid in children. Onset Onset of anticonvulsant, anxiolytic, or sedative action occurs in 1–5 minutes following IV administration. Duration Duration of anticonvulsant, anxiolytic, or sedative action is 15–60 minutes following IV administration. Distribution: Apparently widely distributed into body tissues; crosses the blood-brain barrier. Diazepam and its metabolites cross the placenta and are distributed into milk. Plasma Protein Binding: Diazepam and desmethyldiazepam: 95–98%. Elimination: Metabolized in the liver by CYP2C19 and CYP3A4 to active metabolites. Excreted principally in urine as inactive conjugates. Half-life: Diazepam: 20–50 hours. Metabolites: Desmethyldiazepam: 30–200 hours. Temazepam: 5–20 hours. Oxazepam: 3–21 hours. [format] => 1 [safe] =>Absorption:
Apparently well absorbed following oral administration.
Absorption is slow and erratic following IM administration.
Rapidly and well absorbed following rectal administration as gel or solution; bioavailability averages 80–102%. Peak plasma concentrations attained within 1.5 hours following rectal administration of the gel in adults; absorption from gel may be more rapid in children.
Onset
Onset of anticonvulsant, anxiolytic, or sedative action occurs in 1–5 minutes following IV administration.
Duration
Duration of anticonvulsant, anxiolytic, or sedative action is 15–60 minutes following IV administration.
Distribution:
Apparently widely distributed into body tissues; crosses the blood-brain barrier.
Diazepam and its metabolites cross the placenta and are distributed into milk.
Plasma Protein Binding:
Diazepam and desmethyldiazepam: 95–98%.
Elimination:
Metabolized in the liver by CYP2C19 and CYP3A4 to active metabolites.
Excreted principally in urine as inactive conjugates.
Half-life:
Diazepam: 20–50 hours.
Metabolites: Desmethyldiazepam: 30–200 hours. Temazepam: 5–20 hours. Oxazepam: 3–21 hours.
Absorption:
Apparently well absorbed following oral administration.
Absorption is slow and erratic following IM administration.
Rapidly and well absorbed following rectal administration as gel or solution; bioavailability averages 80–102%. Peak plasma concentrations attained within 1.5 hours following rectal administration of the gel in adults; absorption from gel may be more rapid in children.
Onset
Onset of anticonvulsant, anxiolytic, or sedative action occurs in 1–5 minutes following IV administration.
Duration
Duration of anticonvulsant, anxiolytic, or sedative action is 15–60 minutes following IV administration.
Distribution:
Apparently widely distributed into body tissues; crosses the blood-brain barrier.
Diazepam and its metabolites cross the placenta and are distributed into milk.
Plasma Protein Binding:
Diazepam and desmethyldiazepam: 95–98%.
Elimination:
Metabolized in the liver by CYP2C19 and CYP3A4 to active metabolites.
Excreted principally in urine as inactive conjugates.
Half-life:
Diazepam: 20–50 hours.
Metabolites: Desmethyldiazepam: 30–200 hours. Temazepam: 5–20 hours. Oxazepam: 3–21 hours.
Absorption:
Apparently well absorbed following oral administration.
Absorption is slow and erratic following IM administration.
Rapidly and well absorbed following rectal administration as gel or solution; bioavailability averages 80–102%. Peak plasma concentrations attained within 1.5 hours following rectal administration of the gel in adults; absorption from gel may be more rapid in children.
Onset
Onset of anticonvulsant, anxiolytic, or sedative action occurs in 1–5 minutes following IV administration.
Duration
Duration of anticonvulsant, anxiolytic, or sedative action is 15–60 minutes following IV administration.
Distribution:
Apparently widely distributed into body tissues; crosses the blood-brain barrier.
Diazepam and its metabolites cross the placenta and are distributed into milk.
Plasma Protein Binding:
Diazepam and desmethyldiazepam: 95–98%.
Elimination:
Metabolized in the liver by CYP2C19 and CYP3A4 to active metabolites.
Excreted principally in urine as inactive conjugates.
Half-life:
Diazepam: 20–50 hours.
Metabolites: Desmethyldiazepam: 30–200 hours. Temazepam: 5–20 hours. Oxazepam: 3–21 hours.
Absorption:
Apparently well absorbed following oral administration.
Absorption is slow and erratic following IM administration.
Rapidly and well absorbed following rectal administration as gel or solution; bioavailability averages 80–102%. Peak plasma concentrations attained within 1.5 hours following rectal administration of the gel in adults; absorption from gel may be more rapid in children.
Onset
Onset of anticonvulsant, anxiolytic, or sedative action occurs in 1–5 minutes following IV administration.
Duration
Duration of anticonvulsant, anxiolytic, or sedative action is 15–60 minutes following IV administration.
Distribution:
Apparently widely distributed into body tissues; crosses the blood-brain barrier.
Diazepam and its metabolites cross the placenta and are distributed into milk.
Plasma Protein Binding:
Diazepam and desmethyldiazepam: 95–98%.
Elimination:
Metabolized in the liver by CYP2C19 and CYP3A4 to active metabolites.
Excreted principally in urine as inactive conjugates.
Half-life:
Diazepam: 20–50 hours.
Metabolites: Desmethyldiazepam: 30–200 hours. Temazepam: 5–20 hours. Oxazepam: 3–21 hours.
Absorption:
Apparently well absorbed following oral administration.
Absorption is slow and erratic following IM administration.
Rapidly and well absorbed following rectal administration as gel or solution; bioavailability averages 80–102%. Peak plasma concentrations attained within 1.5 hours following rectal administration of the gel in adults; absorption from gel may be more rapid in children.
Onset
Onset of anticonvulsant, anxiolytic, or sedative action occurs in 1–5 minutes following IV administration.
Duration
Duration of anticonvulsant, anxiolytic, or sedative action is 15–60 minutes following IV administration.
Distribution:
Apparently widely distributed into body tissues; crosses the blood-brain barrier.
Diazepam and its metabolites cross the placenta and are distributed into milk.
Plasma Protein Binding:
Diazepam and desmethyldiazepam: 95–98%.
Elimination:
Metabolized in the liver by CYP2C19 and CYP3A4 to active metabolites.
Excreted principally in urine as inactive conjugates.
Half-life:
Diazepam: 20–50 hours.
Metabolites: Desmethyldiazepam: 30–200 hours. Temazepam: 5–20 hours. Oxazepam: 3–21 hours.
treat anxiety disorders, alcohol withdrawal symptoms, or muscle spasms. Diazepam is sometimes used with other medications to treat seizures.
[#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] =>treat anxiety disorders, alcohol withdrawal symptoms, or muscle spasms. Diazepam is sometimes used with other medications to treat seizures.
) [#title] => [#description] => [#children] =>treat anxiety disorders, alcohol withdrawal symptoms, or muscle spasms. Diazepam is sometimes used with other medications to treat seizures.
[#printed] => 1 ) [#single] => 1 [#attributes] => Array ( ) [#required] => [#parents] => Array ( ) [#tree] => [#context] => full [#page] => 1 [#field_name] => field_indications [#title] => Indications [#access] => 1 [#label_display] => above [#teaser] => [#node] => stdClass Object *RECURSION* [#type] => content_field [#children] =>treat anxiety disorders, alcohol withdrawal symptoms, or muscle spasms. Diazepam is sometimes used with other medications to treat seizures.
[#printed] => 1 ) [#title] => [#description] => [#children] =>treat anxiety disorders, alcohol withdrawal symptoms, or muscle spasms. Diazepam is sometimes used with other medications to treat seizures.
Diazepam is contraindicated in patients with a known hypersensitivity to this drug; acute narrow angle glaucoma; and open angle glaucoma unless patients are receiving appropriate therapy.
[#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] =>Diazepam is contraindicated in patients with a known hypersensitivity to this drug; acute narrow angle glaucoma; and open angle glaucoma unless patients are receiving appropriate therapy.
) [#title] => [#description] => [#children] =>Diazepam is contraindicated in patients with a known hypersensitivity to this drug; acute narrow angle glaucoma; and open angle glaucoma unless patients are receiving appropriate therapy.
[#printed] => 1 ) [#single] => 1 [#attributes] => Array ( ) [#required] => [#parents] => Array ( ) [#tree] => [#context] => full [#page] => 1 [#field_name] => field_contraindications [#title] => Contraindications [#access] => 1 [#label_display] => above [#teaser] => [#node] => stdClass Object *RECURSION* [#type] => content_field [#children] =>Diazepam is contraindicated in patients with a known hypersensitivity to this drug; acute narrow angle glaucoma; and open angle glaucoma unless patients are receiving appropriate therapy.
[#printed] => 1 ) [#title] => [#description] => [#children] =>Diazepam is contraindicated in patients with a known hypersensitivity to this drug; acute narrow angle glaucoma; and open angle glaucoma unless patients are receiving appropriate therapy.
Although seizures may be brought under control promptly, a significant proportion of patients experience a return to seizure activity, presumably due to the short-lived effect of diazepam after I.V. administration. The physician should be prepared to re-administer the drug. However, diazepam is not recommended for maintenance, and once seizures are brought under control, consideration should be given to the administration of agents useful in longer term control of seizures. Diazepam Injection has produced hypotension or muscular weakness in some patients particularly when used with narcotics, barbiturates or alcohol. Lower doses (usually 2 mg to 5 mg) should be used for elderly and debilitated patients.
[#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] =>Although seizures may be brought under control promptly, a significant proportion of patients experience a return to seizure activity, presumably due to the short-lived effect of diazepam after I.V. administration. The physician should be prepared to re-administer the drug. However, diazepam is not recommended for maintenance, and once seizures are brought under control, consideration should be given to the administration of agents useful in longer term control of seizures. Diazepam Injection has produced hypotension or muscular weakness in some patients particularly when used with narcotics, barbiturates or alcohol. Lower doses (usually 2 mg to 5 mg) should be used for elderly and debilitated patients.
) [#title] => [#description] => [#children] =>Although seizures may be brought under control promptly, a significant proportion of patients experience a return to seizure activity, presumably due to the short-lived effect of diazepam after I.V. administration. The physician should be prepared to re-administer the drug. However, diazepam is not recommended for maintenance, and once seizures are brought under control, consideration should be given to the administration of agents useful in longer term control of seizures. Diazepam Injection has produced hypotension or muscular weakness in some patients particularly when used with narcotics, barbiturates or alcohol. Lower doses (usually 2 mg to 5 mg) should be used for elderly and debilitated patients.
[#printed] => 1 ) [#single] => 1 [#attributes] => Array ( ) [#required] => [#parents] => Array ( ) [#tree] => [#context] => full [#page] => 1 [#field_name] => field_precautions [#title] => Precautions [#access] => 1 [#label_display] => above [#teaser] => [#node] => stdClass Object *RECURSION* [#type] => content_field [#children] =>Although seizures may be brought under control promptly, a significant proportion of patients experience a return to seizure activity, presumably due to the short-lived effect of diazepam after I.V. administration. The physician should be prepared to re-administer the drug. However, diazepam is not recommended for maintenance, and once seizures are brought under control, consideration should be given to the administration of agents useful in longer term control of seizures. Diazepam Injection has produced hypotension or muscular weakness in some patients particularly when used with narcotics, barbiturates or alcohol. Lower doses (usually 2 mg to 5 mg) should be used for elderly and debilitated patients.
[#printed] => 1 ) [#title] => [#description] => [#children] =>Although seizures may be brought under control promptly, a significant proportion of patients experience a return to seizure activity, presumably due to the short-lived effect of diazepam after I.V. administration. The physician should be prepared to re-administer the drug. However, diazepam is not recommended for maintenance, and once seizures are brought under control, consideration should be given to the administration of agents useful in longer term control of seizures. Diazepam Injection has produced hypotension or muscular weakness in some patients particularly when used with narcotics, barbiturates or alcohol. Lower doses (usually 2 mg to 5 mg) should be used for elderly and debilitated patients.
• cimetidine;
• omeprazole;
• phenytoin;
• an antibiotic--clarithromycin, erythromycin, telithromycin;
• an antidepressant such as fluoxetine, fluoxetine, and others;
• antifungal medicine--itraconazole, ketoconazole, voriconazole;
• heart or blood pressure medication such as diltiazem, nicardipine, quinidine, verapamil, and others; or
• HIV/AIDS medicine--atazanavir, delavirdine, fosamprenavir, indinavir, nelfinavir, saquinavir, or ritonavir.
• cimetidine;
• omeprazole;
• phenytoin;
• an antibiotic--clarithromycin, erythromycin, telithromycin;
• an antidepressant such as fluoxetine, fluoxetine, and others;
• antifungal medicine--itraconazole, ketoconazole, voriconazole;
• heart or blood pressure medication such as diltiazem, nicardipine, quinidine, verapamil, and others; or
• HIV/AIDS medicine--atazanavir, delavirdine, fosamprenavir, indinavir, nelfinavir, saquinavir, or ritonavir.
• cimetidine;
• omeprazole;
• phenytoin;
• an antibiotic--clarithromycin, erythromycin, telithromycin;
• an antidepressant such as fluoxetine, fluoxetine, and others;
• antifungal medicine--itraconazole, ketoconazole, voriconazole;
• heart or blood pressure medication such as diltiazem, nicardipine, quinidine, verapamil, and others; or
• HIV/AIDS medicine--atazanavir, delavirdine, fosamprenavir, indinavir, nelfinavir, saquinavir, or ritonavir.
• cimetidine;
• omeprazole;
• phenytoin;
• an antibiotic--clarithromycin, erythromycin, telithromycin;
• an antidepressant such as fluoxetine, fluoxetine, and others;
• antifungal medicine--itraconazole, ketoconazole, voriconazole;
• heart or blood pressure medication such as diltiazem, nicardipine, quinidine, verapamil, and others; or
• HIV/AIDS medicine--atazanavir, delavirdine, fosamprenavir, indinavir, nelfinavir, saquinavir, or ritonavir.
• cimetidine;
• omeprazole;
• phenytoin;
• an antibiotic--clarithromycin, erythromycin, telithromycin;
• an antidepressant such as fluoxetine, fluoxetine, and others;
• antifungal medicine--itraconazole, ketoconazole, voriconazole;
• heart or blood pressure medication such as diltiazem, nicardipine, quinidine, verapamil, and others; or
• HIV/AIDS medicine--atazanavir, delavirdine, fosamprenavir, indinavir, nelfinavir, saquinavir, or ritonavir.
• confusion, hallucinations, unusual thoughts or behavior;
• unusual risk-taking behavior, decreased inhibitions, no fear of danger;
• depressed mood, thoughts of suicide or hurting yourself;
• hyperactivity, agitation, aggression, hostility;
• new or worsening seizures;
• weak or shallow breathing;
• a feeling like you might pass out;
• muscle twitching, tremor;
• loss of bladder control; or
• little or no urinating.
Common diazepam side effects may include:
• memory problems;
• drowsiness, tired feeling;
• dizziness, spinning sensation;
• feeling restless or irritable;
• muscle weakness;
• nausea, constipation;
• drooling or dry mouth, slurred speech;
• blurred vision, double vision;
• mild skin rash, itching; or
• loss of interest in sex.
• confusion, hallucinations, unusual thoughts or behavior;
• unusual risk-taking behavior, decreased inhibitions, no fear of danger;
• depressed mood, thoughts of suicide or hurting yourself;
• hyperactivity, agitation, aggression, hostility;
• new or worsening seizures;
• weak or shallow breathing;
• a feeling like you might pass out;
• muscle twitching, tremor;
• loss of bladder control; or
• little or no urinating.
Common diazepam side effects may include:
• memory problems;
• drowsiness, tired feeling;
• dizziness, spinning sensation;
• feeling restless or irritable;
• muscle weakness;
• nausea, constipation;
• drooling or dry mouth, slurred speech;
• blurred vision, double vision;
• mild skin rash, itching; or
• loss of interest in sex.
• confusion, hallucinations, unusual thoughts or behavior;
• unusual risk-taking behavior, decreased inhibitions, no fear of danger;
• depressed mood, thoughts of suicide or hurting yourself;
• hyperactivity, agitation, aggression, hostility;
• new or worsening seizures;
• weak or shallow breathing;
• a feeling like you might pass out;
• muscle twitching, tremor;
• loss of bladder control; or
• little or no urinating.
Common diazepam side effects may include:
• memory problems;
• drowsiness, tired feeling;
• dizziness, spinning sensation;
• feeling restless or irritable;
• muscle weakness;
• nausea, constipation;
• drooling or dry mouth, slurred speech;
• blurred vision, double vision;
• mild skin rash, itching; or
• loss of interest in sex.
• confusion, hallucinations, unusual thoughts or behavior;
• unusual risk-taking behavior, decreased inhibitions, no fear of danger;
• depressed mood, thoughts of suicide or hurting yourself;
• hyperactivity, agitation, aggression, hostility;
• new or worsening seizures;
• weak or shallow breathing;
• a feeling like you might pass out;
• muscle twitching, tremor;
• loss of bladder control; or
• little or no urinating.
Common diazepam side effects may include:
• memory problems;
• drowsiness, tired feeling;
• dizziness, spinning sensation;
• feeling restless or irritable;
• muscle weakness;
• nausea, constipation;
• drooling or dry mouth, slurred speech;
• blurred vision, double vision;
• mild skin rash, itching; or
• loss of interest in sex.
• confusion, hallucinations, unusual thoughts or behavior;
• unusual risk-taking behavior, decreased inhibitions, no fear of danger;
• depressed mood, thoughts of suicide or hurting yourself;
• hyperactivity, agitation, aggression, hostility;
• new or worsening seizures;
• weak or shallow breathing;
• a feeling like you might pass out;
• muscle twitching, tremor;
• loss of bladder control; or
• little or no urinating.
Common diazepam side effects may include:
• memory problems;
• drowsiness, tired feeling;
• dizziness, spinning sensation;
• feeling restless or irritable;
• muscle weakness;
• nausea, constipation;
• drooling or dry mouth, slurred speech;
• blurred vision, double vision;
• mild skin rash, itching; or
• loss of interest in sex.
• Store below 30 C°
• Protect from light and freezing
• Store below 30 C°
• Protect from light and freezing
• Store below 30 C°
• Protect from light and freezing
• Store below 30 C°
• Protect from light and freezing
• Store below 30 C°
• Protect from light and freezing
• Injection 10mg/2ml: Box of 10,100 Ampoules
[#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] =>• Injection 10mg/2ml: Box of 10,100 Ampoules
) [#title] => [#description] => [#children] =>• Injection 10mg/2ml: Box of 10,100 Ampoules
[#printed] => 1 ) [#single] => 1 [#attributes] => Array ( ) [#required] => [#parents] => Array ( ) [#tree] => [#context] => full [#page] => 1 [#field_name] => field_packing [#title] => Packing [#access] => 1 [#label_display] => above [#teaser] => [#node] => stdClass Object *RECURSION* [#type] => content_field [#children] =>• Injection 10mg/2ml: Box of 10,100 Ampoules
[#printed] => 1 ) [#title] => [#description] => [#children] =>• Injection 10mg/2ml: Box of 10,100 Ampoules
ZEPADIC®
Injection 10mg/2ml
Benzodiazepines
Anxiolytic,Sedative,Hypnotic Anticonvulsant and Antipsychotic
Category D
facilitation of the action of gamma aminobutyric acid (GABA), an inhibitory neurotransmitter in the central nervous system.
Absorption:
Apparently well absorbed following oral administration.
Absorption is slow and erratic following IM administration.
Rapidly and well absorbed following rectal administration as gel or solution; bioavailability averages 80–102%. Peak plasma concentrations attained within 1.5 hours following rectal administration of the gel in adults; absorption from gel may be more rapid in children.
Onset
Onset of anticonvulsant, anxiolytic, or sedative action occurs in 1–5 minutes following IV administration.
Duration
Duration of anticonvulsant, anxiolytic, or sedative action is 15–60 minutes following IV administration.
Distribution:
Apparently widely distributed into body tissues; crosses the blood-brain barrier.
Diazepam and its metabolites cross the placenta and are distributed into milk.
Plasma Protein Binding:
Diazepam and desmethyldiazepam: 95–98%.
Elimination:
Metabolized in the liver by CYP2C19 and CYP3A4 to active metabolites.
Excreted principally in urine as inactive conjugates.
Half-life:
Diazepam: 20–50 hours.
Metabolites: Desmethyldiazepam: 30–200 hours. Temazepam: 5–20 hours. Oxazepam: 3–21 hours.
treat anxiety disorders, alcohol withdrawal symptoms, or muscle spasms. Diazepam is sometimes used with other medications to treat seizures.
Diazepam is contraindicated in patients with a known hypersensitivity to this drug; acute narrow angle glaucoma; and open angle glaucoma unless patients are receiving appropriate therapy.
Although seizures may be brought under control promptly, a significant proportion of patients experience a return to seizure activity, presumably due to the short-lived effect of diazepam after I.V. administration. The physician should be prepared to re-administer the drug. However, diazepam is not recommended for maintenance, and once seizures are brought under control, consideration should be given to the administration of agents useful in longer term control of seizures. Diazepam Injection has produced hypotension or muscular weakness in some patients particularly when used with narcotics, barbiturates or alcohol. Lower doses (usually 2 mg to 5 mg) should be used for elderly and debilitated patients.
• cimetidine;
• omeprazole;
• phenytoin;
• an antibiotic--clarithromycin, erythromycin, telithromycin;
• an antidepressant such as fluoxetine, fluoxetine, and others;
• antifungal medicine--itraconazole, ketoconazole, voriconazole;
• heart or blood pressure medication such as diltiazem, nicardipine, quinidine, verapamil, and others; or
• HIV/AIDS medicine--atazanavir, delavirdine, fosamprenavir, indinavir, nelfinavir, saquinavir, or ritonavir.
• confusion, hallucinations, unusual thoughts or behavior;
• unusual risk-taking behavior, decreased inhibitions, no fear of danger;
• depressed mood, thoughts of suicide or hurting yourself;
• hyperactivity, agitation, aggression, hostility;
• new or worsening seizures;
• weak or shallow breathing;
• a feeling like you might pass out;
• muscle twitching, tremor;
• loss of bladder control; or
• little or no urinating.
Common diazepam side effects may include:
• memory problems;
• drowsiness, tired feeling;
• dizziness, spinning sensation;
• feeling restless or irritable;
• muscle weakness;
• nausea, constipation;
• drooling or dry mouth, slurred speech;
• blurred vision, double vision;
• mild skin rash, itching; or
• loss of interest in sex.
• Store below 30 C°
• Protect from light and freezing
• Injection 10mg/2ml: Box of 10,100 Ampoules
(C) Copyright Caspian Tamin Pharmaceutical Co.
All Rights Reserved.