Selectively activates vascular 5-HT1 receptor sites, causing vasoconstriction in intracranial arteries
Bioavailability is high (96%) following subcutaneous injection, but low (14%) following oral administration because of first-pass metabolism. Absorption is rapid after subcutaneous injection, with peak concentration reached in 10 minutes. Less than 20% of the drug is protein bound. The volume of distribution is greater than total body water at 170L. Total plasma clearance is rapid, with an elimination half-life of around 2 hours. There is one major metabolite (an indole acetic acid analogue) which is excreted in the urine as the free acid and its ester glucuronide conjugate.
Acute migraine
• Hypersensitivity to drug
• Hemiplegic or basilar migraine headache
• Ischemic cardiac, cerebrovascular, or peripheral vascular disease (such as a history of myocardial infarction, stroke, angina, or ischemic bowel)
• Uncontrolled hypertension
• Severe hepatic impairment
• MAO inhibitor use within past 14 days
• Use of other 5-HT1 agonists, ergotamine-containing drugs, or ergot-type products within past 24 hours
Use cautiously in:
• patients with cardiovascular risk factors (hypertension, hypercholesterolemia, smoking, obesity, diabetes, amily history of cardiovascular disease, men over age 40, menopausal women)
• elderly patients
• women of childbearing age
• pregnant or breastfeeding patients
• children younger than age 18 (safety not established).
Dihydroergotamine, ergotamine, methysergide: increased risk of vasospastic reaction
Lithium, MAO inhibitors, selective serotonin reuptake inhibitors: weakness, hyperreflexia, incoordination
CNS: headache, malaise, dizziness, drowsiness, fatigue, vertigo, anxiety, tight feeling in head, numbness
CV: angina, chest pressure or tightness, transient hypertension, ECG changes, coronary vasospasm, myocardial infarction
EENT: vision changes, nasal sinus discomfort, throat discomfort
GI: abdominal discomfort, dysphagia
Musculoskeletal: jaw discomfort, muscle cramps, myalgia, neck pain or stiffness
Skin: flushing; tingling; warm, cool or, burning sensation
Other: injection site reaction, feeling of heaviness or tightness
• Store below 30 C°
• Protect from light and freezing
Sumatriptan Injection 6mg / 0.5ml : 1 ampoule/box
-
Injection 6mg/0.5ml
Selective 5-hydroxytryptamine1 (5-HT1) agonist
Vascular headache suppressant
category C
Selectively activates vascular 5-HT1 receptor sites, causing vasoconstriction in intracranial arteries
Bioavailability is high (96%) following subcutaneous injection, but low (14%) following oral administration because of first-pass metabolism. Absorption is rapid after subcutaneous injection, with peak concentration reached in 10 minutes. Less than 20% of the drug is protein bound. The volume of distribution is greater than total body water at 170L. Total plasma clearance is rapid, with an elimination half-life of around 2 hours. There is one major metabolite (an indole acetic acid analogue) which is excreted in the urine as the free acid and its ester glucuronide conjugate.
Acute migraine
• Hypersensitivity to drug
• Hemiplegic or basilar migraine headache
• Ischemic cardiac, cerebrovascular, or peripheral vascular disease (such as a history of myocardial infarction, stroke, angina, or ischemic bowel)
• Uncontrolled hypertension
• Severe hepatic impairment
• MAO inhibitor use within past 14 days
• Use of other 5-HT1 agonists, ergotamine-containing drugs, or ergot-type products within past 24 hours
Use cautiously in:
• patients with cardiovascular risk factors (hypertension, hypercholesterolemia, smoking, obesity, diabetes, amily history of cardiovascular disease, men over age 40, menopausal women)
• elderly patients
• women of childbearing age
• pregnant or breastfeeding patients
• children younger than age 18 (safety not established).
Dihydroergotamine, ergotamine, methysergide: increased risk of vasospastic reaction
Lithium, MAO inhibitors, selective serotonin reuptake inhibitors: weakness, hyperreflexia, incoordination
CNS: headache, malaise, dizziness, drowsiness, fatigue, vertigo, anxiety, tight feeling in head, numbness
CV: angina, chest pressure or tightness, transient hypertension, ECG changes, coronary vasospasm, myocardial infarction
EENT: vision changes, nasal sinus discomfort, throat discomfort
GI: abdominal discomfort, dysphagia
Musculoskeletal: jaw discomfort, muscle cramps, myalgia, neck pain or stiffness
Skin: flushing; tingling; warm, cool or, burning sensation
Other: injection site reaction, feeling of heaviness or tightness
• Store below 30 C°
• Protect from light and freezing
Sumatriptan Injection 6mg / 0.5ml : 1 ampoule/box
-
[view] =>-
) ) [field_contraindications] => Array ( [0] => Array ( [value] => • Hypersensitivity to drug • Hemiplegic or basilar migraine headache • Ischemic cardiac, cerebrovascular, or peripheral vascular disease (such as a history of myocardial infarction, stroke, angina, or ischemic bowel) • Uncontrolled hypertension • Severe hepatic impairment • MAO inhibitor use within past 14 days • Use of other 5-HT1 agonists, ergotamine-containing drugs, or ergot-type products within past 24 hours [format] => 1 [safe] =>• Hypersensitivity to drug
• Hemiplegic or basilar migraine headache
• Ischemic cardiac, cerebrovascular, or peripheral vascular disease (such as a history of myocardial infarction, stroke, angina, or ischemic bowel)
• Uncontrolled hypertension
• Severe hepatic impairment
• MAO inhibitor use within past 14 days
• Use of other 5-HT1 agonists, ergotamine-containing drugs, or ergot-type products within past 24 hours
• Hypersensitivity to drug
• Hemiplegic or basilar migraine headache
• Ischemic cardiac, cerebrovascular, or peripheral vascular disease (such as a history of myocardial infarction, stroke, angina, or ischemic bowel)
• Uncontrolled hypertension
• Severe hepatic impairment
• MAO inhibitor use within past 14 days
• Use of other 5-HT1 agonists, ergotamine-containing drugs, or ergot-type products within past 24 hours
Injection 6mg/0.5ml
[view] =>Injection 6mg/0.5ml
) ) [field_drug_interactions] => Array ( [0] => Array ( [value] => Dihydroergotamine, ergotamine, methysergide: increased risk of vasospastic reaction Lithium, MAO inhibitors, selective serotonin reuptake inhibitors: weakness, hyperreflexia, incoordination [format] => 1 [safe] =>Dihydroergotamine, ergotamine, methysergide: increased risk of vasospastic reaction
Lithium, MAO inhibitors, selective serotonin reuptake inhibitors: weakness, hyperreflexia, incoordination
Dihydroergotamine, ergotamine, methysergide: increased risk of vasospastic reaction
Lithium, MAO inhibitors, selective serotonin reuptake inhibitors: weakness, hyperreflexia, incoordination
Acute migraine
[view] =>Acute migraine
) ) [field_packing] => Array ( [0] => Array ( [value] => Sumatriptan Injection 6mg / 0.5ml : 1 ampoule/box [format] => 1 [safe] =>Sumatriptan Injection 6mg / 0.5ml : 1 ampoule/box
[view] =>Sumatriptan Injection 6mg / 0.5ml : 1 ampoule/box
) ) [field_pdf] => Array ( [0] => Array ( [fid] => 154 [uid] => 1 [filename] => sumatriptan.pdf [filepath] => sites/default/files/pdf/sumatriptan.pdf [filemime] => application/pdf [filesize] => 419432 [status] => 1 [timestamp] => 1329482464 [list] => 1 [data] => [i18nsync] => 1 [nid] => 213 [view] => ) ) [field_pharmacokinetics] => Array ( [0] => Array ( [value] => Bioavailability is high (96%) following subcutaneous injection, but low (14%) following oral administration because of first-pass metabolism. Absorption is rapid after subcutaneous injection, with peak concentration reached in 10 minutes. Less than 20% of the drug is protein bound. The volume of distribution is greater than total body water at 170L. Total plasma clearance is rapid, with an elimination half-life of around 2 hours. There is one major metabolite (an indole acetic acid analogue) which is excreted in the urine as the free acid and its ester glucuronide conjugate. [format] => 1 [safe] =>Bioavailability is high (96%) following subcutaneous injection, but low (14%) following oral administration because of first-pass metabolism. Absorption is rapid after subcutaneous injection, with peak concentration reached in 10 minutes. Less than 20% of the drug is protein bound. The volume of distribution is greater than total body water at 170L. Total plasma clearance is rapid, with an elimination half-life of around 2 hours. There is one major metabolite (an indole acetic acid analogue) which is excreted in the urine as the free acid and its ester glucuronide conjugate.
[view] =>Bioavailability is high (96%) following subcutaneous injection, but low (14%) following oral administration because of first-pass metabolism. Absorption is rapid after subcutaneous injection, with peak concentration reached in 10 minutes. Less than 20% of the drug is protein bound. The volume of distribution is greater than total body water at 170L. Total plasma clearance is rapid, with an elimination half-life of around 2 hours. There is one major metabolite (an indole acetic acid analogue) which is excreted in the urine as the free acid and its ester glucuronide conjugate.
) ) [field_pharmacological_category] => Array ( [0] => Array ( [value] => Selective 5-hydroxytryptamine1 (5-HT1) agonist [format] => 1 [safe] =>Selective 5-hydroxytryptamine1 (5-HT1) agonist
[view] =>Selective 5-hydroxytryptamine1 (5-HT1) agonist
) ) [field_precautions] => Array ( [0] => Array ( [value] => Use cautiously in: • patients with cardiovascular risk factors (hypertension, hypercholesterolemia, smoking, obesity, diabetes, amily history of cardiovascular disease, men over age 40, menopausal women) • elderly patients • women of childbearing age • pregnant or breastfeeding patients • children younger than age 18 (safety not established). [format] => 1 [safe] =>Use cautiously in:
• patients with cardiovascular risk factors (hypertension, hypercholesterolemia, smoking, obesity, diabetes, amily history of cardiovascular disease, men over age 40, menopausal women)
• elderly patients
• women of childbearing age
• pregnant or breastfeeding patients
• children younger than age 18 (safety not established).
Use cautiously in:
• patients with cardiovascular risk factors (hypertension, hypercholesterolemia, smoking, obesity, diabetes, amily history of cardiovascular disease, men over age 40, menopausal women)
• elderly patients
• women of childbearing age
• pregnant or breastfeeding patients
• children younger than age 18 (safety not established).
category C
[view] =>category C
) ) [field_references] => Array ( [0] => Array ( [value] => [format] => [safe] => [view] => ) ) [field_side_effects] => Array ( [0] => Array ( [value] => CNS: headache, malaise, dizziness, drowsiness, fatigue, vertigo, anxiety, tight feeling in head, numbness CV: angina, chest pressure or tightness, transient hypertension, ECG changes, coronary vasospasm, myocardial infarction EENT: vision changes, nasal sinus discomfort, throat discomfort GI: abdominal discomfort, dysphagia Musculoskeletal: jaw discomfort, muscle cramps, myalgia, neck pain or stiffness Skin: flushing; tingling; warm, cool or, burning sensation Other: injection site reaction, feeling of heaviness or tightness [format] => 1 [safe] =>CNS: headache, malaise, dizziness, drowsiness, fatigue, vertigo, anxiety, tight feeling in head, numbness
CV: angina, chest pressure or tightness, transient hypertension, ECG changes, coronary vasospasm, myocardial infarction
EENT: vision changes, nasal sinus discomfort, throat discomfort
GI: abdominal discomfort, dysphagia
Musculoskeletal: jaw discomfort, muscle cramps, myalgia, neck pain or stiffness
Skin: flushing; tingling; warm, cool or, burning sensation
Other: injection site reaction, feeling of heaviness or tightness
CNS: headache, malaise, dizziness, drowsiness, fatigue, vertigo, anxiety, tight feeling in head, numbness
CV: angina, chest pressure or tightness, transient hypertension, ECG changes, coronary vasospasm, myocardial infarction
EENT: vision changes, nasal sinus discomfort, throat discomfort
GI: abdominal discomfort, dysphagia
Musculoskeletal: jaw discomfort, muscle cramps, myalgia, neck pain or stiffness
Skin: flushing; tingling; warm, cool or, burning sensation
Other: injection site reaction, feeling of heaviness or tightness
• Store below 30 C°
• Protect from light and freezing
• Store below 30 C°
• Protect from light and freezing
Vascular headache suppressant
[view] =>Vascular headache suppressant
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[#printed] => 1 ) [#title] => [#description] => [#children] =>-
Injection 6mg/0.5ml
[#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] =>Injection 6mg/0.5ml
) [#title] => [#description] => [#children] =>Injection 6mg/0.5ml
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[#printed] => 1 ) [#title] => [#description] => [#children] =>Injection 6mg/0.5ml
Selective 5-hydroxytryptamine1 (5-HT1) agonist
[#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] =>Selective 5-hydroxytryptamine1 (5-HT1) agonist
) [#title] => [#description] => [#children] =>Selective 5-hydroxytryptamine1 (5-HT1) agonist
[#printed] => 1 ) [#single] => 1 [#attributes] => Array ( ) [#required] => [#parents] => Array ( ) [#tree] => [#context] => full [#page] => 1 [#field_name] => field_pharmacological_category [#title] => Pharmacological Category [#access] => 1 [#label_display] => above [#teaser] => [#node] => stdClass Object *RECURSION* [#type] => content_field [#children] =>Selective 5-hydroxytryptamine1 (5-HT1) agonist
[#printed] => 1 ) [#title] => [#description] => [#children] =>Selective 5-hydroxytryptamine1 (5-HT1) agonist
Vascular headache suppressant
[#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] =>Vascular headache suppressant
) [#title] => [#description] => [#children] =>Vascular headache suppressant
[#printed] => 1 ) [#single] => 1 [#attributes] => Array ( ) [#required] => [#parents] => Array ( ) [#tree] => [#context] => full [#page] => 1 [#field_name] => field_therapeutic_category [#title] => Therapeutic Category [#access] => 1 [#label_display] => above [#teaser] => [#node] => stdClass Object *RECURSION* [#type] => content_field [#children] =>Vascular headache suppressant
[#printed] => 1 ) [#title] => [#description] => [#children] =>Vascular headache suppressant
category C
[#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] =>category C
) [#title] => [#description] => [#children] =>category C
[#printed] => 1 ) [#single] => 1 [#attributes] => Array ( ) [#required] => [#parents] => Array ( ) [#tree] => [#context] => full [#page] => 1 [#field_name] => field_pregnancy_category [#title] => Pregnancy Category [#access] => 1 [#label_display] => above [#teaser] => [#node] => stdClass Object *RECURSION* [#type] => content_field [#children] =>category C
[#printed] => 1 ) [#title] => [#description] => [#children] =>category C
Selectively activates vascular 5-HT1 receptor sites, causing vasoconstriction in intracranial arteries
[#title] => [#description] => [#printed] => 1 ) [field_pharmacokinetics] => Array ( [#type_name] => product [#context] => full [#field_name] => field_pharmacokinetics [#post_render] => Array ( [0] => content_field_wrapper_post_render ) [#weight] => 4 [field] => Array ( [#description] => [items] => Array ( [0] => Array ( [#formatter] => default [#node] => stdClass Object *RECURSION* [#type_name] => product [#field_name] => field_pharmacokinetics [#weight] => 0 [#theme] => text_formatter_default [#item] => Array ( [value] => Bioavailability is high (96%) following subcutaneous injection, but low (14%) following oral administration because of first-pass metabolism. Absorption is rapid after subcutaneous injection, with peak concentration reached in 10 minutes. Less than 20% of the drug is protein bound. The volume of distribution is greater than total body water at 170L. Total plasma clearance is rapid, with an elimination half-life of around 2 hours. There is one major metabolite (an indole acetic acid analogue) which is excreted in the urine as the free acid and its ester glucuronide conjugate. [format] => 1 [safe] =>Bioavailability is high (96%) following subcutaneous injection, but low (14%) following oral administration because of first-pass metabolism. Absorption is rapid after subcutaneous injection, with peak concentration reached in 10 minutes. Less than 20% of the drug is protein bound. The volume of distribution is greater than total body water at 170L. Total plasma clearance is rapid, with an elimination half-life of around 2 hours. There is one major metabolite (an indole acetic acid analogue) which is excreted in the urine as the free acid and its ester glucuronide conjugate.
[#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] =>Bioavailability is high (96%) following subcutaneous injection, but low (14%) following oral administration because of first-pass metabolism. Absorption is rapid after subcutaneous injection, with peak concentration reached in 10 minutes. Less than 20% of the drug is protein bound. The volume of distribution is greater than total body water at 170L. Total plasma clearance is rapid, with an elimination half-life of around 2 hours. There is one major metabolite (an indole acetic acid analogue) which is excreted in the urine as the free acid and its ester glucuronide conjugate.
) [#title] => [#description] => [#children] =>Bioavailability is high (96%) following subcutaneous injection, but low (14%) following oral administration because of first-pass metabolism. Absorption is rapid after subcutaneous injection, with peak concentration reached in 10 minutes. Less than 20% of the drug is protein bound. The volume of distribution is greater than total body water at 170L. Total plasma clearance is rapid, with an elimination half-life of around 2 hours. There is one major metabolite (an indole acetic acid analogue) which is excreted in the urine as the free acid and its ester glucuronide conjugate.
[#printed] => 1 ) [#single] => 1 [#attributes] => Array ( ) [#required] => [#parents] => Array ( ) [#tree] => [#context] => full [#page] => 1 [#field_name] => field_pharmacokinetics [#title] => Pharmacokinetics [#access] => 1 [#label_display] => above [#teaser] => [#node] => stdClass Object *RECURSION* [#type] => content_field [#children] =>Bioavailability is high (96%) following subcutaneous injection, but low (14%) following oral administration because of first-pass metabolism. Absorption is rapid after subcutaneous injection, with peak concentration reached in 10 minutes. Less than 20% of the drug is protein bound. The volume of distribution is greater than total body water at 170L. Total plasma clearance is rapid, with an elimination half-life of around 2 hours. There is one major metabolite (an indole acetic acid analogue) which is excreted in the urine as the free acid and its ester glucuronide conjugate.
[#printed] => 1 ) [#title] => [#description] => [#children] =>Bioavailability is high (96%) following subcutaneous injection, but low (14%) following oral administration because of first-pass metabolism. Absorption is rapid after subcutaneous injection, with peak concentration reached in 10 minutes. Less than 20% of the drug is protein bound. The volume of distribution is greater than total body water at 170L. Total plasma clearance is rapid, with an elimination half-life of around 2 hours. There is one major metabolite (an indole acetic acid analogue) which is excreted in the urine as the free acid and its ester glucuronide conjugate.
Acute migraine
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) [#title] => [#description] => [#children] =>Acute migraine
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[#printed] => 1 ) [#title] => [#description] => [#children] =>Acute migraine
• Hypersensitivity to drug
• Hemiplegic or basilar migraine headache
• Ischemic cardiac, cerebrovascular, or peripheral vascular disease (such as a history of myocardial infarction, stroke, angina, or ischemic bowel)
• Uncontrolled hypertension
• Severe hepatic impairment
• MAO inhibitor use within past 14 days
• Use of other 5-HT1 agonists, ergotamine-containing drugs, or ergot-type products within past 24 hours
• Hypersensitivity to drug
• Hemiplegic or basilar migraine headache
• Ischemic cardiac, cerebrovascular, or peripheral vascular disease (such as a history of myocardial infarction, stroke, angina, or ischemic bowel)
• Uncontrolled hypertension
• Severe hepatic impairment
• MAO inhibitor use within past 14 days
• Use of other 5-HT1 agonists, ergotamine-containing drugs, or ergot-type products within past 24 hours
• Hypersensitivity to drug
• Hemiplegic or basilar migraine headache
• Ischemic cardiac, cerebrovascular, or peripheral vascular disease (such as a history of myocardial infarction, stroke, angina, or ischemic bowel)
• Uncontrolled hypertension
• Severe hepatic impairment
• MAO inhibitor use within past 14 days
• Use of other 5-HT1 agonists, ergotamine-containing drugs, or ergot-type products within past 24 hours
• Hypersensitivity to drug
• Hemiplegic or basilar migraine headache
• Ischemic cardiac, cerebrovascular, or peripheral vascular disease (such as a history of myocardial infarction, stroke, angina, or ischemic bowel)
• Uncontrolled hypertension
• Severe hepatic impairment
• MAO inhibitor use within past 14 days
• Use of other 5-HT1 agonists, ergotamine-containing drugs, or ergot-type products within past 24 hours
• Hypersensitivity to drug
• Hemiplegic or basilar migraine headache
• Ischemic cardiac, cerebrovascular, or peripheral vascular disease (such as a history of myocardial infarction, stroke, angina, or ischemic bowel)
• Uncontrolled hypertension
• Severe hepatic impairment
• MAO inhibitor use within past 14 days
• Use of other 5-HT1 agonists, ergotamine-containing drugs, or ergot-type products within past 24 hours
Use cautiously in:
• patients with cardiovascular risk factors (hypertension, hypercholesterolemia, smoking, obesity, diabetes, amily history of cardiovascular disease, men over age 40, menopausal women)
• elderly patients
• women of childbearing age
• pregnant or breastfeeding patients
• children younger than age 18 (safety not established).
Use cautiously in:
• patients with cardiovascular risk factors (hypertension, hypercholesterolemia, smoking, obesity, diabetes, amily history of cardiovascular disease, men over age 40, menopausal women)
• elderly patients
• women of childbearing age
• pregnant or breastfeeding patients
• children younger than age 18 (safety not established).
Use cautiously in:
• patients with cardiovascular risk factors (hypertension, hypercholesterolemia, smoking, obesity, diabetes, amily history of cardiovascular disease, men over age 40, menopausal women)
• elderly patients
• women of childbearing age
• pregnant or breastfeeding patients
• children younger than age 18 (safety not established).
Use cautiously in:
• patients with cardiovascular risk factors (hypertension, hypercholesterolemia, smoking, obesity, diabetes, amily history of cardiovascular disease, men over age 40, menopausal women)
• elderly patients
• women of childbearing age
• pregnant or breastfeeding patients
• children younger than age 18 (safety not established).
Use cautiously in:
• patients with cardiovascular risk factors (hypertension, hypercholesterolemia, smoking, obesity, diabetes, amily history of cardiovascular disease, men over age 40, menopausal women)
• elderly patients
• women of childbearing age
• pregnant or breastfeeding patients
• children younger than age 18 (safety not established).
Dihydroergotamine, ergotamine, methysergide: increased risk of vasospastic reaction
Lithium, MAO inhibitors, selective serotonin reuptake inhibitors: weakness, hyperreflexia, incoordination
Dihydroergotamine, ergotamine, methysergide: increased risk of vasospastic reaction
Lithium, MAO inhibitors, selective serotonin reuptake inhibitors: weakness, hyperreflexia, incoordination
Dihydroergotamine, ergotamine, methysergide: increased risk of vasospastic reaction
Lithium, MAO inhibitors, selective serotonin reuptake inhibitors: weakness, hyperreflexia, incoordination
Dihydroergotamine, ergotamine, methysergide: increased risk of vasospastic reaction
Lithium, MAO inhibitors, selective serotonin reuptake inhibitors: weakness, hyperreflexia, incoordination
Dihydroergotamine, ergotamine, methysergide: increased risk of vasospastic reaction
Lithium, MAO inhibitors, selective serotonin reuptake inhibitors: weakness, hyperreflexia, incoordination
CNS: headache, malaise, dizziness, drowsiness, fatigue, vertigo, anxiety, tight feeling in head, numbness
CV: angina, chest pressure or tightness, transient hypertension, ECG changes, coronary vasospasm, myocardial infarction
EENT: vision changes, nasal sinus discomfort, throat discomfort
GI: abdominal discomfort, dysphagia
Musculoskeletal: jaw discomfort, muscle cramps, myalgia, neck pain or stiffness
Skin: flushing; tingling; warm, cool or, burning sensation
Other: injection site reaction, feeling of heaviness or tightness
CNS: headache, malaise, dizziness, drowsiness, fatigue, vertigo, anxiety, tight feeling in head, numbness
CV: angina, chest pressure or tightness, transient hypertension, ECG changes, coronary vasospasm, myocardial infarction
EENT: vision changes, nasal sinus discomfort, throat discomfort
GI: abdominal discomfort, dysphagia
Musculoskeletal: jaw discomfort, muscle cramps, myalgia, neck pain or stiffness
Skin: flushing; tingling; warm, cool or, burning sensation
Other: injection site reaction, feeling of heaviness or tightness
CNS: headache, malaise, dizziness, drowsiness, fatigue, vertigo, anxiety, tight feeling in head, numbness
CV: angina, chest pressure or tightness, transient hypertension, ECG changes, coronary vasospasm, myocardial infarction
EENT: vision changes, nasal sinus discomfort, throat discomfort
GI: abdominal discomfort, dysphagia
Musculoskeletal: jaw discomfort, muscle cramps, myalgia, neck pain or stiffness
Skin: flushing; tingling; warm, cool or, burning sensation
Other: injection site reaction, feeling of heaviness or tightness
CNS: headache, malaise, dizziness, drowsiness, fatigue, vertigo, anxiety, tight feeling in head, numbness
CV: angina, chest pressure or tightness, transient hypertension, ECG changes, coronary vasospasm, myocardial infarction
EENT: vision changes, nasal sinus discomfort, throat discomfort
GI: abdominal discomfort, dysphagia
Musculoskeletal: jaw discomfort, muscle cramps, myalgia, neck pain or stiffness
Skin: flushing; tingling; warm, cool or, burning sensation
Other: injection site reaction, feeling of heaviness or tightness
CNS: headache, malaise, dizziness, drowsiness, fatigue, vertigo, anxiety, tight feeling in head, numbness
CV: angina, chest pressure or tightness, transient hypertension, ECG changes, coronary vasospasm, myocardial infarction
EENT: vision changes, nasal sinus discomfort, throat discomfort
GI: abdominal discomfort, dysphagia
Musculoskeletal: jaw discomfort, muscle cramps, myalgia, neck pain or stiffness
Skin: flushing; tingling; warm, cool or, burning sensation
Other: injection site reaction, feeling of heaviness or tightness
• Store below 30 C°
• Protect from light and freezing
• Store below 30 C°
• Protect from light and freezing
• Store below 30 C°
• Protect from light and freezing
• Store below 30 C°
• Protect from light and freezing
• Store below 30 C°
• Protect from light and freezing
Sumatriptan Injection 6mg / 0.5ml : 1 ampoule/box
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Injection 6mg/0.5ml
Selective 5-hydroxytryptamine1 (5-HT1) agonist
Vascular headache suppressant
category C
Selectively activates vascular 5-HT1 receptor sites, causing vasoconstriction in intracranial arteries
Bioavailability is high (96%) following subcutaneous injection, but low (14%) following oral administration because of first-pass metabolism. Absorption is rapid after subcutaneous injection, with peak concentration reached in 10 minutes. Less than 20% of the drug is protein bound. The volume of distribution is greater than total body water at 170L. Total plasma clearance is rapid, with an elimination half-life of around 2 hours. There is one major metabolite (an indole acetic acid analogue) which is excreted in the urine as the free acid and its ester glucuronide conjugate.
Acute migraine
• Hypersensitivity to drug
• Hemiplegic or basilar migraine headache
• Ischemic cardiac, cerebrovascular, or peripheral vascular disease (such as a history of myocardial infarction, stroke, angina, or ischemic bowel)
• Uncontrolled hypertension
• Severe hepatic impairment
• MAO inhibitor use within past 14 days
• Use of other 5-HT1 agonists, ergotamine-containing drugs, or ergot-type products within past 24 hours
Use cautiously in:
• patients with cardiovascular risk factors (hypertension, hypercholesterolemia, smoking, obesity, diabetes, amily history of cardiovascular disease, men over age 40, menopausal women)
• elderly patients
• women of childbearing age
• pregnant or breastfeeding patients
• children younger than age 18 (safety not established).
Dihydroergotamine, ergotamine, methysergide: increased risk of vasospastic reaction
Lithium, MAO inhibitors, selective serotonin reuptake inhibitors: weakness, hyperreflexia, incoordination
CNS: headache, malaise, dizziness, drowsiness, fatigue, vertigo, anxiety, tight feeling in head, numbness
CV: angina, chest pressure or tightness, transient hypertension, ECG changes, coronary vasospasm, myocardial infarction
EENT: vision changes, nasal sinus discomfort, throat discomfort
GI: abdominal discomfort, dysphagia
Musculoskeletal: jaw discomfort, muscle cramps, myalgia, neck pain or stiffness
Skin: flushing; tingling; warm, cool or, burning sensation
Other: injection site reaction, feeling of heaviness or tightness
• Store below 30 C°
• Protect from light and freezing
Sumatriptan Injection 6mg / 0.5ml : 1 ampoule/box
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