Piroxicam

Generic Name: Piroxicam
Brand Name: Rocamix®
Dosage Form: Injection 20mg/1ml
Pharmacological Category: Non-steroidal anti-inflammatory drug (NSAID)
Therapeutic Category: Analgesic, anti-inflammatory, antipyretic
Pregnancy Category: category C

Pharmacology

The mechanism of action of piroxicam, like that of other NSAIDs, is not completely understood but may be related to prostaglandin synthetase inhibition.

Pharmacokinetics:

Distribution
The apparent volume of distribution of piroxicam is approximately 0.14L/kg. Ninety-nine percent of plasma piroxicam is bound to plasma proteins. Piroxicam is excreted into human milk. The presence in breast milk has been determined during initial and long-term conditions (52 days). Piroxicam appeared in breast milk at about 1% to 3% of the maternal concentration. No accumulation of piroxicam occurred in milk relative to that in plasma during treatment.
Metabolism
Metabolism of piroxicam occurs by hydroxylation at the 5 position of the pyridyl side chain and conjugation of this product; by cyclodehydration; and by a sequence of reactions involving hydrolysis of the amide linkage, decarboxylation, ring contraction, and N-demethylation. The biotransformation products of piroxicam metabolism are reported to not have any anti-inflammatory activity.
Excretion
Piroxicam and its biotransformation products are excreted in urine and feces, with about twice as much appearing in the urine as in the feces. Approximately 5% of a Piroxicam dose is excreted unchanged. The plasma half-life (T½) for Piroxicam is approximately 50 hours.

Indications:

• osteoarthritis
• rheumatoid arthritis
• ankylosing spondylitis
• primary dysmenorrhea

Contraindications:

• Hypersensitivity to drug or other NSAIDs (including aspirin)
• Third trimester of pregnancy

Drug Interactions:

Acetaminophen (chronic use), cyclosporine, gold compounds: increased risk of adverse renal reactions
Anticoagulants, cefamandole, cefoperazone, cefotetan, clopidogrel, eptifibatide, heparin, plicamycin, thrombolytics, ticlopidine, tirofiban, valproic acid, vitamin A: increased risk of bleeding
Antineoplastics: increased risk of hematologic toxicity
Aspirin: decreased piroxicam blood level and efficacy
Corticosteroids, other NSAIDs: additive adverse GI reactions
Diuretics, other antihypertensives: decreased response to these drugs
Insulin, oral hypoglycemics: increased risk of hypoglycemia
Lithium: increased lithium blood level and risk of toxicity
Probenecid: increased piroxicam blood level and risk of toxicity

Side Effects:

CNS: headache, drowsiness, dizziness
CV: edema, hypertension, vasculitis, tachycardia, arrhythmias
EENT: blurred vision, tinnitus
GU: proteinuria, renal failure
Hematologic: anemia, blood dyscrasias
Hepatic: jaundice, hepatitis
Skin: rash
Other: allergic reactions including anaphylaxis

Storage:

• Store below 30 C°
• Protect from light and freezing

Packing:

Piroxicam injection 20mg /ml : 10 ampoules/box
Piroxicam 0.5% topical gel : 1 tube/box- 60 g

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Image: 
Brand Name: 

Rocamix®

Dosage Form: 

Injection 20mg/1ml

Pharmacological Category: 

Non-steroidal anti-inflammatory drug (NSAID)

Therapeutic Category: 

Analgesic, anti-inflammatory, antipyretic

Pregnancy Category: 

category C

The mechanism of action of piroxicam, like that of other NSAIDs, is not completely understood but may be related to prostaglandin synthetase inhibition.

Pharmacokinetics: 

Distribution
The apparent volume of distribution of piroxicam is approximately 0.14L/kg. Ninety-nine percent of plasma piroxicam is bound to plasma proteins. Piroxicam is excreted into human milk. The presence in breast milk has been determined during initial and long-term conditions (52 days). Piroxicam appeared in breast milk at about 1% to 3% of the maternal concentration. No accumulation of piroxicam occurred in milk relative to that in plasma during treatment.
Metabolism
Metabolism of piroxicam occurs by hydroxylation at the 5 position of the pyridyl side chain and conjugation of this product; by cyclodehydration; and by a sequence of reactions involving hydrolysis of the amide linkage, decarboxylation, ring contraction, and N-demethylation. The biotransformation products of piroxicam metabolism are reported to not have any anti-inflammatory activity.
Excretion
Piroxicam and its biotransformation products are excreted in urine and feces, with about twice as much appearing in the urine as in the feces. Approximately 5% of a Piroxicam dose is excreted unchanged. The plasma half-life (T½) for Piroxicam is approximately 50 hours.

Indications: 

• osteoarthritis
• rheumatoid arthritis
• ankylosing spondylitis
• primary dysmenorrhea

Contraindications: 

• Hypersensitivity to drug or other NSAIDs (including aspirin)
• Third trimester of pregnancy

Drug Interactions: 

Acetaminophen (chronic use), cyclosporine, gold compounds: increased risk of adverse renal reactions
Anticoagulants, cefamandole, cefoperazone, cefotetan, clopidogrel, eptifibatide, heparin, plicamycin, thrombolytics, ticlopidine, tirofiban, valproic acid, vitamin A: increased risk of bleeding
Antineoplastics: increased risk of hematologic toxicity
Aspirin: decreased piroxicam blood level and efficacy
Corticosteroids, other NSAIDs: additive adverse GI reactions
Diuretics, other antihypertensives: decreased response to these drugs
Insulin, oral hypoglycemics: increased risk of hypoglycemia
Lithium: increased lithium blood level and risk of toxicity
Probenecid: increased piroxicam blood level and risk of toxicity

Side Effects: 

CNS: headache, drowsiness, dizziness
CV: edema, hypertension, vasculitis, tachycardia, arrhythmias
EENT: blurred vision, tinnitus
GU: proteinuria, renal failure
Hematologic: anemia, blood dyscrasias
Hepatic: jaundice, hepatitis
Skin: rash
Other: allergic reactions including anaphylaxis

Storage: 

• Store below 30 C°
• Protect from light and freezing

Packing: 

Piroxicam injection 20mg /ml : 10 ampoules/box
Piroxicam 0.5% topical gel : 1 tube/box- 60 g

PDF: 
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• Third trimester of pregnancy

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Aspirin: decreased piroxicam blood level and efficacy
Corticosteroids, other NSAIDs: additive adverse GI reactions
Diuretics, other antihypertensives: decreased response to these drugs
Insulin, oral hypoglycemics: increased risk of hypoglycemia
Lithium: increased lithium blood level and risk of toxicity
Probenecid: increased piroxicam blood level and risk of toxicity

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Acetaminophen (chronic use), cyclosporine, gold compounds: increased risk of adverse renal reactions
Anticoagulants, cefamandole, cefoperazone, cefotetan, clopidogrel, eptifibatide, heparin, plicamycin, thrombolytics, ticlopidine, tirofiban, valproic acid, vitamin A: increased risk of bleeding
Antineoplastics: increased risk of hematologic toxicity
Aspirin: decreased piroxicam blood level and efficacy
Corticosteroids, other NSAIDs: additive adverse GI reactions
Diuretics, other antihypertensives: decreased response to these drugs
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Lithium: increased lithium blood level and risk of toxicity
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• primary dysmenorrhea

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Distribution
The apparent volume of distribution of piroxicam is approximately 0.14L/kg. Ninety-nine percent of plasma piroxicam is bound to plasma proteins. Piroxicam is excreted into human milk. The presence in breast milk has been determined during initial and long-term conditions (52 days). Piroxicam appeared in breast milk at about 1% to 3% of the maternal concentration. No accumulation of piroxicam occurred in milk relative to that in plasma during treatment.
Metabolism
Metabolism of piroxicam occurs by hydroxylation at the 5 position of the pyridyl side chain and conjugation of this product; by cyclodehydration; and by a sequence of reactions involving hydrolysis of the amide linkage, decarboxylation, ring contraction, and N-demethylation. The biotransformation products of piroxicam metabolism are reported to not have any anti-inflammatory activity.
Excretion
Piroxicam and its biotransformation products are excreted in urine and feces, with about twice as much appearing in the urine as in the feces. Approximately 5% of a Piroxicam dose is excreted unchanged. The plasma half-life (T½) for Piroxicam is approximately 50 hours.

[view] =>

Distribution
The apparent volume of distribution of piroxicam is approximately 0.14L/kg. Ninety-nine percent of plasma piroxicam is bound to plasma proteins. Piroxicam is excreted into human milk. The presence in breast milk has been determined during initial and long-term conditions (52 days). Piroxicam appeared in breast milk at about 1% to 3% of the maternal concentration. No accumulation of piroxicam occurred in milk relative to that in plasma during treatment.
Metabolism
Metabolism of piroxicam occurs by hydroxylation at the 5 position of the pyridyl side chain and conjugation of this product; by cyclodehydration; and by a sequence of reactions involving hydrolysis of the amide linkage, decarboxylation, ring contraction, and N-demethylation. The biotransformation products of piroxicam metabolism are reported to not have any anti-inflammatory activity.
Excretion
Piroxicam and its biotransformation products are excreted in urine and feces, with about twice as much appearing in the urine as in the feces. Approximately 5% of a Piroxicam dose is excreted unchanged. The plasma half-life (T½) for Piroxicam is approximately 50 hours.

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Hepatic: jaundice, hepatitis
Skin: rash
Other: allergic reactions including anaphylaxis

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CNS: headache, drowsiness, dizziness
CV: edema, hypertension, vasculitis, tachycardia, arrhythmias
EENT: blurred vision, tinnitus
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Hematologic: anemia, blood dyscrasias
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The mechanism of action of piroxicam, like that of other NSAIDs, is not completely understood but may be related to prostaglandin synthetase inhibition.

[#title] => [#description] => [#printed] => 1 ) [field_pharmacokinetics] => Array ( [#type_name] => product [#context] => full [#field_name] => field_pharmacokinetics [#post_render] => Array ( [0] => content_field_wrapper_post_render ) [#weight] => 4 [field] => Array ( [#description] => [items] => Array ( [0] => Array ( [#formatter] => default [#node] => stdClass Object *RECURSION* [#type_name] => product [#field_name] => field_pharmacokinetics [#weight] => 0 [#theme] => text_formatter_default [#item] => Array ( [value] => Distribution The apparent volume of distribution of piroxicam is approximately 0.14L/kg. Ninety-nine percent of plasma piroxicam is bound to plasma proteins. Piroxicam is excreted into human milk. The presence in breast milk has been determined during initial and long-term conditions (52 days). Piroxicam appeared in breast milk at about 1% to 3% of the maternal concentration. No accumulation of piroxicam occurred in milk relative to that in plasma during treatment. Metabolism Metabolism of piroxicam occurs by hydroxylation at the 5 position of the pyridyl side chain and conjugation of this product; by cyclodehydration; and by a sequence of reactions involving hydrolysis of the amide linkage, decarboxylation, ring contraction, and N-demethylation. The biotransformation products of piroxicam metabolism are reported to not have any anti-inflammatory activity. Excretion Piroxicam and its biotransformation products are excreted in urine and feces, with about twice as much appearing in the urine as in the feces. Approximately 5% of a Piroxicam dose is excreted unchanged. The plasma half-life (T½) for Piroxicam is approximately 50 hours. [format] => 1 [safe] =>

Distribution
The apparent volume of distribution of piroxicam is approximately 0.14L/kg. Ninety-nine percent of plasma piroxicam is bound to plasma proteins. Piroxicam is excreted into human milk. The presence in breast milk has been determined during initial and long-term conditions (52 days). Piroxicam appeared in breast milk at about 1% to 3% of the maternal concentration. No accumulation of piroxicam occurred in milk relative to that in plasma during treatment.
Metabolism
Metabolism of piroxicam occurs by hydroxylation at the 5 position of the pyridyl side chain and conjugation of this product; by cyclodehydration; and by a sequence of reactions involving hydrolysis of the amide linkage, decarboxylation, ring contraction, and N-demethylation. The biotransformation products of piroxicam metabolism are reported to not have any anti-inflammatory activity.
Excretion
Piroxicam and its biotransformation products are excreted in urine and feces, with about twice as much appearing in the urine as in the feces. Approximately 5% of a Piroxicam dose is excreted unchanged. The plasma half-life (T½) for Piroxicam is approximately 50 hours.

[#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] =>

Distribution
The apparent volume of distribution of piroxicam is approximately 0.14L/kg. Ninety-nine percent of plasma piroxicam is bound to plasma proteins. Piroxicam is excreted into human milk. The presence in breast milk has been determined during initial and long-term conditions (52 days). Piroxicam appeared in breast milk at about 1% to 3% of the maternal concentration. No accumulation of piroxicam occurred in milk relative to that in plasma during treatment.
Metabolism
Metabolism of piroxicam occurs by hydroxylation at the 5 position of the pyridyl side chain and conjugation of this product; by cyclodehydration; and by a sequence of reactions involving hydrolysis of the amide linkage, decarboxylation, ring contraction, and N-demethylation. The biotransformation products of piroxicam metabolism are reported to not have any anti-inflammatory activity.
Excretion
Piroxicam and its biotransformation products are excreted in urine and feces, with about twice as much appearing in the urine as in the feces. Approximately 5% of a Piroxicam dose is excreted unchanged. The plasma half-life (T½) for Piroxicam is approximately 50 hours.

) [#title] => [#description] => [#children] =>

Distribution
The apparent volume of distribution of piroxicam is approximately 0.14L/kg. Ninety-nine percent of plasma piroxicam is bound to plasma proteins. Piroxicam is excreted into human milk. The presence in breast milk has been determined during initial and long-term conditions (52 days). Piroxicam appeared in breast milk at about 1% to 3% of the maternal concentration. No accumulation of piroxicam occurred in milk relative to that in plasma during treatment.
Metabolism
Metabolism of piroxicam occurs by hydroxylation at the 5 position of the pyridyl side chain and conjugation of this product; by cyclodehydration; and by a sequence of reactions involving hydrolysis of the amide linkage, decarboxylation, ring contraction, and N-demethylation. The biotransformation products of piroxicam metabolism are reported to not have any anti-inflammatory activity.
Excretion
Piroxicam and its biotransformation products are excreted in urine and feces, with about twice as much appearing in the urine as in the feces. Approximately 5% of a Piroxicam dose is excreted unchanged. The plasma half-life (T½) for Piroxicam is approximately 50 hours.

[#printed] => 1 ) [#single] => 1 [#attributes] => Array ( ) [#required] => [#parents] => Array ( ) [#tree] => [#context] => full [#page] => 1 [#field_name] => field_pharmacokinetics [#title] => Pharmacokinetics [#access] => 1 [#label_display] => above [#teaser] => [#node] => stdClass Object *RECURSION* [#type] => content_field [#children] =>

Distribution
The apparent volume of distribution of piroxicam is approximately 0.14L/kg. Ninety-nine percent of plasma piroxicam is bound to plasma proteins. Piroxicam is excreted into human milk. The presence in breast milk has been determined during initial and long-term conditions (52 days). Piroxicam appeared in breast milk at about 1% to 3% of the maternal concentration. No accumulation of piroxicam occurred in milk relative to that in plasma during treatment.
Metabolism
Metabolism of piroxicam occurs by hydroxylation at the 5 position of the pyridyl side chain and conjugation of this product; by cyclodehydration; and by a sequence of reactions involving hydrolysis of the amide linkage, decarboxylation, ring contraction, and N-demethylation. The biotransformation products of piroxicam metabolism are reported to not have any anti-inflammatory activity.
Excretion
Piroxicam and its biotransformation products are excreted in urine and feces, with about twice as much appearing in the urine as in the feces. Approximately 5% of a Piroxicam dose is excreted unchanged. The plasma half-life (T½) for Piroxicam is approximately 50 hours.

[#printed] => 1 ) [#title] => [#description] => [#children] =>
Pharmacokinetics: 

Distribution
The apparent volume of distribution of piroxicam is approximately 0.14L/kg. Ninety-nine percent of plasma piroxicam is bound to plasma proteins. Piroxicam is excreted into human milk. The presence in breast milk has been determined during initial and long-term conditions (52 days). Piroxicam appeared in breast milk at about 1% to 3% of the maternal concentration. No accumulation of piroxicam occurred in milk relative to that in plasma during treatment.
Metabolism
Metabolism of piroxicam occurs by hydroxylation at the 5 position of the pyridyl side chain and conjugation of this product; by cyclodehydration; and by a sequence of reactions involving hydrolysis of the amide linkage, decarboxylation, ring contraction, and N-demethylation. The biotransformation products of piroxicam metabolism are reported to not have any anti-inflammatory activity.
Excretion
Piroxicam and its biotransformation products are excreted in urine and feces, with about twice as much appearing in the urine as in the feces. Approximately 5% of a Piroxicam dose is excreted unchanged. The plasma half-life (T½) for Piroxicam is approximately 50 hours.

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• osteoarthritis
• rheumatoid arthritis
• ankylosing spondylitis
• primary dysmenorrhea

[#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] =>

• osteoarthritis
• rheumatoid arthritis
• ankylosing spondylitis
• primary dysmenorrhea

) [#title] => [#description] => [#children] =>

• osteoarthritis
• rheumatoid arthritis
• ankylosing spondylitis
• primary dysmenorrhea

[#printed] => 1 ) [#single] => 1 [#attributes] => Array ( ) [#required] => [#parents] => Array ( ) [#tree] => [#context] => full [#page] => 1 [#field_name] => field_indications [#title] => Indications [#access] => 1 [#label_display] => above [#teaser] => [#node] => stdClass Object *RECURSION* [#type] => content_field [#children] =>

• osteoarthritis
• rheumatoid arthritis
• ankylosing spondylitis
• primary dysmenorrhea

[#printed] => 1 ) [#title] => [#description] => [#children] =>
Indications: 

• osteoarthritis
• rheumatoid arthritis
• ankylosing spondylitis
• primary dysmenorrhea

[#printed] => 1 ) [field_administration_and_dosage] => Array ( [#type_name] => product [#context] => full [#field_name] => field_administration_and_dosage [#post_render] => Array ( [0] => content_field_wrapper_post_render ) [#weight] => 6 [field] => Array ( [#description] => [items] => Array ( [0] => Array ( [#formatter] => default [#node] => stdClass Object *RECURSION* [#type_name] => product [#field_name] => field_administration_and_dosage [#weight] => 0 [#theme] => text_formatter_default [#item] => Array ( [value] => [format] => [safe] => [#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => ) [#title] => [#description] => [#printed] => 1 ) [#single] => 1 [#attributes] => Array ( ) [#required] => [#parents] => Array ( ) [#tree] => [#context] => full [#page] => 1 [#field_name] => field_administration_and_dosage [#title] => Administration and Dosage [#access] => 1 [#label_display] => above [#teaser] => [#node] => stdClass Object *RECURSION* [#type] => content_field [#printed] => 1 ) [#title] => [#description] => [#printed] => 1 ) [field_contraindications] => Array ( [#type_name] => product [#context] => full [#field_name] => field_contraindications [#post_render] => Array ( [0] => content_field_wrapper_post_render ) [#weight] => 7 [field] => Array ( [#description] => [items] => Array ( [0] => Array ( [#formatter] => default [#node] => stdClass Object *RECURSION* [#type_name] => product [#field_name] => field_contraindications [#weight] => 0 [#theme] => text_formatter_default [#item] => Array ( [value] => • Hypersensitivity to drug or other NSAIDs (including aspirin) • Third trimester of pregnancy [format] => 1 [safe] =>

• Hypersensitivity to drug or other NSAIDs (including aspirin)
• Third trimester of pregnancy

[#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] =>

• Hypersensitivity to drug or other NSAIDs (including aspirin)
• Third trimester of pregnancy

) [#title] => [#description] => [#children] =>

• Hypersensitivity to drug or other NSAIDs (including aspirin)
• Third trimester of pregnancy

[#printed] => 1 ) [#single] => 1 [#attributes] => Array ( ) [#required] => [#parents] => Array ( ) [#tree] => [#context] => full [#page] => 1 [#field_name] => field_contraindications [#title] => Contraindications [#access] => 1 [#label_display] => above [#teaser] => [#node] => stdClass Object *RECURSION* [#type] => content_field [#children] =>

• Hypersensitivity to drug or other NSAIDs (including aspirin)
• Third trimester of pregnancy

[#printed] => 1 ) [#title] => [#description] => [#children] =>
Contraindications: 

• Hypersensitivity to drug or other NSAIDs (including aspirin)
• Third trimester of pregnancy

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Acetaminophen (chronic use), cyclosporine, gold compounds: increased risk of adverse renal reactions
Anticoagulants, cefamandole, cefoperazone, cefotetan, clopidogrel, eptifibatide, heparin, plicamycin, thrombolytics, ticlopidine, tirofiban, valproic acid, vitamin A: increased risk of bleeding
Antineoplastics: increased risk of hematologic toxicity
Aspirin: decreased piroxicam blood level and efficacy
Corticosteroids, other NSAIDs: additive adverse GI reactions
Diuretics, other antihypertensives: decreased response to these drugs
Insulin, oral hypoglycemics: increased risk of hypoglycemia
Lithium: increased lithium blood level and risk of toxicity
Probenecid: increased piroxicam blood level and risk of toxicity

[#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] =>

Acetaminophen (chronic use), cyclosporine, gold compounds: increased risk of adverse renal reactions
Anticoagulants, cefamandole, cefoperazone, cefotetan, clopidogrel, eptifibatide, heparin, plicamycin, thrombolytics, ticlopidine, tirofiban, valproic acid, vitamin A: increased risk of bleeding
Antineoplastics: increased risk of hematologic toxicity
Aspirin: decreased piroxicam blood level and efficacy
Corticosteroids, other NSAIDs: additive adverse GI reactions
Diuretics, other antihypertensives: decreased response to these drugs
Insulin, oral hypoglycemics: increased risk of hypoglycemia
Lithium: increased lithium blood level and risk of toxicity
Probenecid: increased piroxicam blood level and risk of toxicity

) [#title] => [#description] => [#children] =>

Acetaminophen (chronic use), cyclosporine, gold compounds: increased risk of adverse renal reactions
Anticoagulants, cefamandole, cefoperazone, cefotetan, clopidogrel, eptifibatide, heparin, plicamycin, thrombolytics, ticlopidine, tirofiban, valproic acid, vitamin A: increased risk of bleeding
Antineoplastics: increased risk of hematologic toxicity
Aspirin: decreased piroxicam blood level and efficacy
Corticosteroids, other NSAIDs: additive adverse GI reactions
Diuretics, other antihypertensives: decreased response to these drugs
Insulin, oral hypoglycemics: increased risk of hypoglycemia
Lithium: increased lithium blood level and risk of toxicity
Probenecid: increased piroxicam blood level and risk of toxicity

[#printed] => 1 ) [#single] => 1 [#attributes] => Array ( ) [#required] => [#parents] => Array ( ) [#tree] => [#context] => full [#page] => 1 [#field_name] => field_drug_interactions [#title] => Drug Interactions [#access] => 1 [#label_display] => above [#teaser] => [#node] => stdClass Object *RECURSION* [#type] => content_field [#children] =>

Acetaminophen (chronic use), cyclosporine, gold compounds: increased risk of adverse renal reactions
Anticoagulants, cefamandole, cefoperazone, cefotetan, clopidogrel, eptifibatide, heparin, plicamycin, thrombolytics, ticlopidine, tirofiban, valproic acid, vitamin A: increased risk of bleeding
Antineoplastics: increased risk of hematologic toxicity
Aspirin: decreased piroxicam blood level and efficacy
Corticosteroids, other NSAIDs: additive adverse GI reactions
Diuretics, other antihypertensives: decreased response to these drugs
Insulin, oral hypoglycemics: increased risk of hypoglycemia
Lithium: increased lithium blood level and risk of toxicity
Probenecid: increased piroxicam blood level and risk of toxicity

[#printed] => 1 ) [#title] => [#description] => [#children] =>
Drug Interactions: 

Acetaminophen (chronic use), cyclosporine, gold compounds: increased risk of adverse renal reactions
Anticoagulants, cefamandole, cefoperazone, cefotetan, clopidogrel, eptifibatide, heparin, plicamycin, thrombolytics, ticlopidine, tirofiban, valproic acid, vitamin A: increased risk of bleeding
Antineoplastics: increased risk of hematologic toxicity
Aspirin: decreased piroxicam blood level and efficacy
Corticosteroids, other NSAIDs: additive adverse GI reactions
Diuretics, other antihypertensives: decreased response to these drugs
Insulin, oral hypoglycemics: increased risk of hypoglycemia
Lithium: increased lithium blood level and risk of toxicity
Probenecid: increased piroxicam blood level and risk of toxicity

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CNS: headache, drowsiness, dizziness
CV: edema, hypertension, vasculitis, tachycardia, arrhythmias
EENT: blurred vision, tinnitus
GU: proteinuria, renal failure
Hematologic: anemia, blood dyscrasias
Hepatic: jaundice, hepatitis
Skin: rash
Other: allergic reactions including anaphylaxis

[#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] =>

CNS: headache, drowsiness, dizziness
CV: edema, hypertension, vasculitis, tachycardia, arrhythmias
EENT: blurred vision, tinnitus
GU: proteinuria, renal failure
Hematologic: anemia, blood dyscrasias
Hepatic: jaundice, hepatitis
Skin: rash
Other: allergic reactions including anaphylaxis

) [#title] => [#description] => [#children] =>

CNS: headache, drowsiness, dizziness
CV: edema, hypertension, vasculitis, tachycardia, arrhythmias
EENT: blurred vision, tinnitus
GU: proteinuria, renal failure
Hematologic: anemia, blood dyscrasias
Hepatic: jaundice, hepatitis
Skin: rash
Other: allergic reactions including anaphylaxis

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CNS: headache, drowsiness, dizziness
CV: edema, hypertension, vasculitis, tachycardia, arrhythmias
EENT: blurred vision, tinnitus
GU: proteinuria, renal failure
Hematologic: anemia, blood dyscrasias
Hepatic: jaundice, hepatitis
Skin: rash
Other: allergic reactions including anaphylaxis

[#printed] => 1 ) [#title] => [#description] => [#children] =>
Side Effects: 

CNS: headache, drowsiness, dizziness
CV: edema, hypertension, vasculitis, tachycardia, arrhythmias
EENT: blurred vision, tinnitus
GU: proteinuria, renal failure
Hematologic: anemia, blood dyscrasias
Hepatic: jaundice, hepatitis
Skin: rash
Other: allergic reactions including anaphylaxis

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• Store below 30 C°
• Protect from light and freezing

[#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] =>

• Store below 30 C°
• Protect from light and freezing

) [#title] => [#description] => [#children] =>

• Store below 30 C°
• Protect from light and freezing

[#printed] => 1 ) [#single] => 1 [#attributes] => Array ( ) [#required] => [#parents] => Array ( ) [#tree] => [#context] => full [#page] => 1 [#field_name] => field_storage [#title] => Storage [#access] => 1 [#label_display] => above [#teaser] => [#node] => stdClass Object *RECURSION* [#type] => content_field [#children] =>

• Store below 30 C°
• Protect from light and freezing

[#printed] => 1 ) [#title] => [#description] => [#children] =>
Storage: 

• Store below 30 C°
• Protect from light and freezing

[#printed] => 1 ) [field_packing] => Array ( [#type_name] => product [#context] => full [#field_name] => field_packing [#post_render] => Array ( [0] => content_field_wrapper_post_render ) [#weight] => 12 [field] => Array ( [#description] => [items] => Array ( [0] => Array ( [#formatter] => default [#node] => stdClass Object *RECURSION* [#type_name] => product [#field_name] => field_packing [#weight] => 0 [#theme] => text_formatter_default [#item] => Array ( [value] => Piroxicam injection 20mg /ml : 10 ampoules/box Piroxicam 0.5% topical gel : 1 tube/box- 60 g [format] => 1 [safe] =>

Piroxicam injection 20mg /ml : 10 ampoules/box
Piroxicam 0.5% topical gel : 1 tube/box- 60 g

[#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] =>

Piroxicam injection 20mg /ml : 10 ampoules/box
Piroxicam 0.5% topical gel : 1 tube/box- 60 g

) [#title] => [#description] => [#children] =>

Piroxicam injection 20mg /ml : 10 ampoules/box
Piroxicam 0.5% topical gel : 1 tube/box- 60 g

[#printed] => 1 ) [#single] => 1 [#attributes] => Array ( ) [#required] => [#parents] => Array ( ) [#tree] => [#context] => full [#page] => 1 [#field_name] => field_packing [#title] => Packing [#access] => 1 [#label_display] => above [#teaser] => [#node] => stdClass Object *RECURSION* [#type] => content_field [#children] =>

Piroxicam injection 20mg /ml : 10 ampoules/box
Piroxicam 0.5% topical gel : 1 tube/box- 60 g

[#printed] => 1 ) [#title] => [#description] => [#children] =>
Packing: 

Piroxicam injection 20mg /ml : 10 ampoules/box
Piroxicam 0.5% topical gel : 1 tube/box- 60 g

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PDF: 
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Image: 
Brand Name: 

Rocamix®

Dosage Form: 

Injection 20mg/1ml

Pharmacological Category: 

Non-steroidal anti-inflammatory drug (NSAID)

Therapeutic Category: 

Analgesic, anti-inflammatory, antipyretic

Pregnancy Category: 

category C

The mechanism of action of piroxicam, like that of other NSAIDs, is not completely understood but may be related to prostaglandin synthetase inhibition.

Pharmacokinetics: 

Distribution
The apparent volume of distribution of piroxicam is approximately 0.14L/kg. Ninety-nine percent of plasma piroxicam is bound to plasma proteins. Piroxicam is excreted into human milk. The presence in breast milk has been determined during initial and long-term conditions (52 days). Piroxicam appeared in breast milk at about 1% to 3% of the maternal concentration. No accumulation of piroxicam occurred in milk relative to that in plasma during treatment.
Metabolism
Metabolism of piroxicam occurs by hydroxylation at the 5 position of the pyridyl side chain and conjugation of this product; by cyclodehydration; and by a sequence of reactions involving hydrolysis of the amide linkage, decarboxylation, ring contraction, and N-demethylation. The biotransformation products of piroxicam metabolism are reported to not have any anti-inflammatory activity.
Excretion
Piroxicam and its biotransformation products are excreted in urine and feces, with about twice as much appearing in the urine as in the feces. Approximately 5% of a Piroxicam dose is excreted unchanged. The plasma half-life (T½) for Piroxicam is approximately 50 hours.

Indications: 

• osteoarthritis
• rheumatoid arthritis
• ankylosing spondylitis
• primary dysmenorrhea

Contraindications: 

• Hypersensitivity to drug or other NSAIDs (including aspirin)
• Third trimester of pregnancy

Drug Interactions: 

Acetaminophen (chronic use), cyclosporine, gold compounds: increased risk of adverse renal reactions
Anticoagulants, cefamandole, cefoperazone, cefotetan, clopidogrel, eptifibatide, heparin, plicamycin, thrombolytics, ticlopidine, tirofiban, valproic acid, vitamin A: increased risk of bleeding
Antineoplastics: increased risk of hematologic toxicity
Aspirin: decreased piroxicam blood level and efficacy
Corticosteroids, other NSAIDs: additive adverse GI reactions
Diuretics, other antihypertensives: decreased response to these drugs
Insulin, oral hypoglycemics: increased risk of hypoglycemia
Lithium: increased lithium blood level and risk of toxicity
Probenecid: increased piroxicam blood level and risk of toxicity

Side Effects: 

CNS: headache, drowsiness, dizziness
CV: edema, hypertension, vasculitis, tachycardia, arrhythmias
EENT: blurred vision, tinnitus
GU: proteinuria, renal failure
Hematologic: anemia, blood dyscrasias
Hepatic: jaundice, hepatitis
Skin: rash
Other: allergic reactions including anaphylaxis

Storage: 

• Store below 30 C°
• Protect from light and freezing

Packing: 

Piroxicam injection 20mg /ml : 10 ampoules/box
Piroxicam 0.5% topical gel : 1 tube/box- 60 g

PDF: 
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CONTACT US:

Head Office:
Address: No.1, Beastoon Ave., Dr. Fatemi Sq., Tehran1431663135 Iran
Tel: (+98 21)-889 65323
Fax: (+98 21)-889 57056
Factory:
Address: Caspian tamin Pharmaceutical Co., Entrance 1, Rasht Industrial Zone, Rasht, Guilan, Iran
Tel: (+98 131) 338-2511- 8
Fax: (+98 131) 338 – 2517