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Chlorpheniramine
Generic Name: Chlorpheniramine
Brand Name: HISTADIC®
Dosage Form: Injection 10mg/1ml
Pharmacological Category: H 1 Blocker
Therapeutic Category: Antihistamines
Pregnancy Category: Category C
Pharmacology
Competitively antagonizes histamine at H 1 receptor sites.
Pharmacokinetics:
Absorption
Readily absorbed.
Distribution
72% protein bound.
Metabolism
Metabolized predominantly in the liver, but also in the lung and kidneys.
Elimination
Renally eliminated, mostly as metabolites within 24 h.
Indications:
Temporary relief of sneezing, itchy, watery eyes, itchy nose or throat, and runny nose caused by hay fever (allergic rhinitis), or other respiratory allergies.
Contraindications:
Hypersensitivity to antihistamines; narrow-angle glaucoma; stenosing peptic ulcer; symptomatic prostatic hypertrophy; asthmatic attack; bladder neck obstruction; pyloroduodenal obstruction; MAO therapy; use in newborn or premature infants and in breast-feeding mothers.
Precautions:
Allergy symptoms
Assess allergy symptoms (eg, cough, rhinitis, nasal congestion, sneezing, watery eyes, or itching nose, throat, or eyes) before starting therapy and periodically during therapy. Notify health care provider if symptoms are not improving or are getting worse.
Dizziness/Drowsiness
Monitor patient for dizziness and excessive drowsiness. If noted, hold therapy and notify health care provider.
Review therapy
Ensure therapy periodically is reviewed to determine if it needs to be continued without change or if a dose change (eg, increase, decrease, discontinuation) is indicated.
Drug Interactions:
Alcohol, CNS depressants, and tricyclic antidepressants
May cause additive CNS depressant effects.
MAOIs
May increase anticholinergic effects of chlorpheniramine.
Ototoxic medications
Concurrent use may mask the symptoms of ototoxicity.
Side Effects:
• fast or uneven heart rate;
• mood changes;
• tremor, seizure (convulsions);
• easy bruising or bleeding, unusual weakness;
• feeling short of breath; or
• little or no urinating.
Common side effects may include:
• dizziness, drowsiness;
• dry mouth, nose, or throat;
• constipation;
• blurred vision; or
• feeling nervous or restless.
Storage:
• Store below 30 C°
• Protect from light and freezing
Packing:
• Injection 10mg/1ml: Box of 5 ampoules
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Image:
Brand Name:
HISTADIC®
Dosage Form:
Injection 10mg/1ml
Pharmacological Category:
H 1 Blocker
Therapeutic Category:
Antihistamines
Pregnancy Category:
Category C
Competitively antagonizes histamine at H 1 receptor sites.
Pharmacokinetics:
Absorption
Readily absorbed.
Distribution
72% protein bound.
Metabolism
Metabolized predominantly in the liver, but also in the lung and kidneys.
Elimination
Renally eliminated, mostly as metabolites within 24 h.
Indications:
Temporary relief of sneezing, itchy, watery eyes, itchy nose or throat, and runny nose caused by hay fever (allergic rhinitis), or other respiratory allergies.
Contraindications:
Hypersensitivity to antihistamines; narrow-angle glaucoma; stenosing peptic ulcer; symptomatic prostatic hypertrophy; asthmatic attack; bladder neck obstruction; pyloroduodenal obstruction; MAO therapy; use in newborn or premature infants and in breast-feeding mothers.
Precautions:
Allergy symptoms
Assess allergy symptoms (eg, cough, rhinitis, nasal congestion, sneezing, watery eyes, or itching nose, throat, or eyes) before starting therapy and periodically during therapy. Notify health care provider if symptoms are not improving or are getting worse.
Dizziness/Drowsiness
Monitor patient for dizziness and excessive drowsiness. If noted, hold therapy and notify health care provider.
Review therapy
Ensure therapy periodically is reviewed to determine if it needs to be continued without change or if a dose change (eg, increase, decrease, discontinuation) is indicated.
Drug Interactions:
Alcohol, CNS depressants, and tricyclic antidepressants
May cause additive CNS depressant effects.
MAOIs
May increase anticholinergic effects of chlorpheniramine.
Ototoxic medications
Concurrent use may mask the symptoms of ototoxicity.
Side Effects:
• fast or uneven heart rate;
• mood changes;
• tremor, seizure (convulsions);
• easy bruising or bleeding, unusual weakness;
• feeling short of breath; or
• little or no urinating.
Common side effects may include:
• dizziness, drowsiness;
• dry mouth, nose, or throat;
• constipation;
• blurred vision; or
• feeling nervous or restless.
Storage:
• Store below 30 C°
• Protect from light and freezing
Packing:
• Injection 10mg/1ml: Box of 5 ampoules
PDF:
)
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[view] =>Hypersensitivity to antihistamines; narrow-angle glaucoma; stenosing peptic ulcer; symptomatic prostatic hypertrophy; asthmatic attack; bladder neck obstruction; pyloroduodenal obstruction; MAO therapy; use in newborn or premature infants and in breast-feeding mothers.
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) ) [field_drug_interactions] => Array ( [0] => Array ( [value] => Alcohol, CNS depressants, and tricyclic antidepressants May cause additive CNS depressant effects. MAOIs May increase anticholinergic effects of chlorpheniramine. Ototoxic medications Concurrent use may mask the symptoms of ototoxicity. [format] => 1 [safe] =>Alcohol, CNS depressants, and tricyclic antidepressants
May cause additive CNS depressant effects.
MAOIs
May increase anticholinergic effects of chlorpheniramine.
Ototoxic medications
Concurrent use may mask the symptoms of ototoxicity.
Alcohol, CNS depressants, and tricyclic antidepressants
May cause additive CNS depressant effects.
MAOIs
May increase anticholinergic effects of chlorpheniramine.
Ototoxic medications
Concurrent use may mask the symptoms of ototoxicity.
Temporary relief of sneezing, itchy, watery eyes, itchy nose or throat, and runny nose caused by hay fever (allergic rhinitis), or other respiratory allergies.
[view] =>Temporary relief of sneezing, itchy, watery eyes, itchy nose or throat, and runny nose caused by hay fever (allergic rhinitis), or other respiratory allergies.
) ) [field_packing] => Array ( [0] => Array ( [value] => • Injection 10mg/1ml: Box of 5 ampoules [format] => 1 [safe] =>• Injection 10mg/1ml: Box of 5 ampoules
[view] =>• Injection 10mg/1ml: Box of 5 ampoules
) ) [field_pdf] => Array ( [0] => Array ( [fid] => 169 [uid] => 1 [filename] => 35-histadic.pdf [filepath] => sites/default/files/pdf/35-histadic.pdf [filemime] => application/pdf [filesize] => 135318 [status] => 1 [timestamp] => 1329486013 [list] => 1 [data] => [i18nsync] => 1 [nid] => 231 [view] => ) ) [field_pharmacokinetics] => Array ( [0] => Array ( [value] => Absorption Readily absorbed. Distribution 72% protein bound. Metabolism Metabolized predominantly in the liver, but also in the lung and kidneys. Elimination Renally eliminated, mostly as metabolites within 24 h. [format] => 1 [safe] =>Absorption
Readily absorbed.
Distribution
72% protein bound.
Metabolism
Metabolized predominantly in the liver, but also in the lung and kidneys.
Elimination
Renally eliminated, mostly as metabolites within 24 h.
Absorption
Readily absorbed.
Distribution
72% protein bound.
Metabolism
Metabolized predominantly in the liver, but also in the lung and kidneys.
Elimination
Renally eliminated, mostly as metabolites within 24 h.
H 1 Blocker
[view] =>H 1 Blocker
) ) [field_precautions] => Array ( [0] => Array ( [value] =>Allergy symptoms
Assess allergy symptoms (eg, cough, rhinitis, nasal congestion, sneezing, watery eyes, or itching nose, throat, or eyes) before starting therapy and periodically during therapy. Notify health care provider if symptoms are not improving or are getting worse.
Dizziness/Drowsiness
Monitor patient for dizziness and excessive drowsiness. If noted, hold therapy and notify health care provider.
Review therapy
Ensure therapy periodically is reviewed to determine if it needs to be continued without change or if a dose change (eg, increase, decrease, discontinuation) is indicated.
Allergy symptoms
Assess allergy symptoms (eg, cough, rhinitis, nasal congestion, sneezing, watery eyes, or itching nose, throat, or eyes) before starting therapy and periodically during therapy. Notify health care provider if symptoms are not improving or are getting worse.
Dizziness/Drowsiness
Monitor patient for dizziness and excessive drowsiness. If noted, hold therapy and notify health care provider.
Review therapy
Ensure therapy periodically is reviewed to determine if it needs to be continued without change or if a dose change (eg, increase, decrease, discontinuation) is indicated.
Allergy symptoms
Assess allergy symptoms (eg, cough, rhinitis, nasal congestion, sneezing, watery eyes, or itching nose, throat, or eyes) before starting therapy and periodically during therapy. Notify health care provider if symptoms are not improving or are getting worse.
Dizziness/Drowsiness
Monitor patient for dizziness and excessive drowsiness. If noted, hold therapy and notify health care provider.
Review therapy
Ensure therapy periodically is reviewed to determine if it needs to be continued without change or if a dose change (eg, increase, decrease, discontinuation) is indicated.
Category C
[view] =>Category C
) ) [field_references] => Array ( [0] => Array ( [value] => [format] => [safe] => [view] => ) ) [field_side_effects] => Array ( [0] => Array ( [value] => • fast or uneven heart rate; • mood changes; • tremor, seizure (convulsions); • easy bruising or bleeding, unusual weakness; • feeling short of breath; or • little or no urinating. Common side effects may include: • dizziness, drowsiness; • dry mouth, nose, or throat; • constipation; • blurred vision; or • feeling nervous or restless. [format] => 1 [safe] =>• fast or uneven heart rate;
• mood changes;
• tremor, seizure (convulsions);
• easy bruising or bleeding, unusual weakness;
• feeling short of breath; or
• little or no urinating.
Common side effects may include:
• dizziness, drowsiness;
• dry mouth, nose, or throat;
• constipation;
• blurred vision; or
• feeling nervous or restless.
• fast or uneven heart rate;
• mood changes;
• tremor, seizure (convulsions);
• easy bruising or bleeding, unusual weakness;
• feeling short of breath; or
• little or no urinating.
Common side effects may include:
• dizziness, drowsiness;
• dry mouth, nose, or throat;
• constipation;
• blurred vision; or
• feeling nervous or restless.
• Store below 30 C°
• Protect from light and freezing
• Store below 30 C°
• Protect from light and freezing
Antihistamines
[view] =>Antihistamines
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[#children] => Image:
HISTADIC®
[#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] =>HISTADIC®
) [#title] => [#description] => [#children] =>HISTADIC®
[#printed] => 1 ) [#single] => 1 [#attributes] => Array ( ) [#required] => [#parents] => Array ( ) [#tree] => [#context] => full [#page] => 1 [#field_name] => field_brand_name [#title] => Brand Name [#access] => 1 [#label_display] => above [#teaser] => [#node] => stdClass Object *RECURSION* [#type] => content_field [#children] =>HISTADIC®
[#printed] => 1 ) [#title] => [#description] => [#children] =>Brand Name:
HISTADIC®
Injection 10mg/1ml
[#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] =>Injection 10mg/1ml
) [#title] => [#description] => [#children] =>Injection 10mg/1ml
[#printed] => 1 ) [#single] => 1 [#attributes] => Array ( ) [#required] => [#parents] => Array ( ) [#tree] => [#context] => full [#page] => 1 [#field_name] => field_dosage_form [#title] => Dosage Form [#access] => 1 [#label_display] => above [#teaser] => [#node] => stdClass Object *RECURSION* [#type] => content_field [#children] =>Injection 10mg/1ml
[#printed] => 1 ) [#title] => [#description] => [#children] =>Dosage Form:
Injection 10mg/1ml
H 1 Blocker
[#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] =>H 1 Blocker
) [#title] => [#description] => [#children] =>H 1 Blocker
[#printed] => 1 ) [#single] => 1 [#attributes] => Array ( ) [#required] => [#parents] => Array ( ) [#tree] => [#context] => full [#page] => 1 [#field_name] => field_pharmacological_category [#title] => Pharmacological Category [#access] => 1 [#label_display] => above [#teaser] => [#node] => stdClass Object *RECURSION* [#type] => content_field [#children] =>H 1 Blocker
[#printed] => 1 ) [#title] => [#description] => [#children] =>Pharmacological Category:
H 1 Blocker
Antihistamines
[#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] =>Antihistamines
) [#title] => [#description] => [#children] =>Antihistamines
[#printed] => 1 ) [#single] => 1 [#attributes] => Array ( ) [#required] => [#parents] => Array ( ) [#tree] => [#context] => full [#page] => 1 [#field_name] => field_therapeutic_category [#title] => Therapeutic Category [#access] => 1 [#label_display] => above [#teaser] => [#node] => stdClass Object *RECURSION* [#type] => content_field [#children] =>Antihistamines
[#printed] => 1 ) [#title] => [#description] => [#children] =>Therapeutic Category:
Antihistamines
Category C
[#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] =>Category C
) [#title] => [#description] => [#children] =>Category C
[#printed] => 1 ) [#single] => 1 [#attributes] => Array ( ) [#required] => [#parents] => Array ( ) [#tree] => [#context] => full [#page] => 1 [#field_name] => field_pregnancy_category [#title] => Pregnancy Category [#access] => 1 [#label_display] => above [#teaser] => [#node] => stdClass Object *RECURSION* [#type] => content_field [#children] =>Category C
[#printed] => 1 ) [#title] => [#description] => [#children] =>Pregnancy Category:
Category C
Competitively antagonizes histamine at H 1 receptor sites.
[#title] => [#description] => [#printed] => 1 ) [field_pharmacokinetics] => Array ( [#type_name] => product [#context] => full [#field_name] => field_pharmacokinetics [#post_render] => Array ( [0] => content_field_wrapper_post_render ) [#weight] => 4 [field] => Array ( [#description] => [items] => Array ( [0] => Array ( [#formatter] => default [#node] => stdClass Object *RECURSION* [#type_name] => product [#field_name] => field_pharmacokinetics [#weight] => 0 [#theme] => text_formatter_default [#item] => Array ( [value] => Absorption Readily absorbed. Distribution 72% protein bound. Metabolism Metabolized predominantly in the liver, but also in the lung and kidneys. Elimination Renally eliminated, mostly as metabolites within 24 h. [format] => 1 [safe] =>Absorption
Readily absorbed.
Distribution
72% protein bound.
Metabolism
Metabolized predominantly in the liver, but also in the lung and kidneys.
Elimination
Renally eliminated, mostly as metabolites within 24 h.
Absorption
Readily absorbed.
Distribution
72% protein bound.
Metabolism
Metabolized predominantly in the liver, but also in the lung and kidneys.
Elimination
Renally eliminated, mostly as metabolites within 24 h.
Absorption
Readily absorbed.
Distribution
72% protein bound.
Metabolism
Metabolized predominantly in the liver, but also in the lung and kidneys.
Elimination
Renally eliminated, mostly as metabolites within 24 h.
Absorption
Readily absorbed.
Distribution
72% protein bound.
Metabolism
Metabolized predominantly in the liver, but also in the lung and kidneys.
Elimination
Renally eliminated, mostly as metabolites within 24 h.
Pharmacokinetics:
Absorption
Readily absorbed.
Distribution
72% protein bound.
Metabolism
Metabolized predominantly in the liver, but also in the lung and kidneys.
Elimination
Renally eliminated, mostly as metabolites within 24 h.
Temporary relief of sneezing, itchy, watery eyes, itchy nose or throat, and runny nose caused by hay fever (allergic rhinitis), or other respiratory allergies.
[#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] =>Temporary relief of sneezing, itchy, watery eyes, itchy nose or throat, and runny nose caused by hay fever (allergic rhinitis), or other respiratory allergies.
) [#title] => [#description] => [#children] =>Temporary relief of sneezing, itchy, watery eyes, itchy nose or throat, and runny nose caused by hay fever (allergic rhinitis), or other respiratory allergies.
[#printed] => 1 ) [#single] => 1 [#attributes] => Array ( ) [#required] => [#parents] => Array ( ) [#tree] => [#context] => full [#page] => 1 [#field_name] => field_indications [#title] => Indications [#access] => 1 [#label_display] => above [#teaser] => [#node] => stdClass Object *RECURSION* [#type] => content_field [#children] =>Temporary relief of sneezing, itchy, watery eyes, itchy nose or throat, and runny nose caused by hay fever (allergic rhinitis), or other respiratory allergies.
[#printed] => 1 ) [#title] => [#description] => [#children] =>Indications:
Temporary relief of sneezing, itchy, watery eyes, itchy nose or throat, and runny nose caused by hay fever (allergic rhinitis), or other respiratory allergies.
Hypersensitivity to antihistamines; narrow-angle glaucoma; stenosing peptic ulcer; symptomatic prostatic hypertrophy; asthmatic attack; bladder neck obstruction; pyloroduodenal obstruction; MAO therapy; use in newborn or premature infants and in breast-feeding mothers.
[#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] =>Hypersensitivity to antihistamines; narrow-angle glaucoma; stenosing peptic ulcer; symptomatic prostatic hypertrophy; asthmatic attack; bladder neck obstruction; pyloroduodenal obstruction; MAO therapy; use in newborn or premature infants and in breast-feeding mothers.
) [#title] => [#description] => [#children] =>Hypersensitivity to antihistamines; narrow-angle glaucoma; stenosing peptic ulcer; symptomatic prostatic hypertrophy; asthmatic attack; bladder neck obstruction; pyloroduodenal obstruction; MAO therapy; use in newborn or premature infants and in breast-feeding mothers.
[#printed] => 1 ) [#single] => 1 [#attributes] => Array ( ) [#required] => [#parents] => Array ( ) [#tree] => [#context] => full [#page] => 1 [#field_name] => field_contraindications [#title] => Contraindications [#access] => 1 [#label_display] => above [#teaser] => [#node] => stdClass Object *RECURSION* [#type] => content_field [#children] =>Hypersensitivity to antihistamines; narrow-angle glaucoma; stenosing peptic ulcer; symptomatic prostatic hypertrophy; asthmatic attack; bladder neck obstruction; pyloroduodenal obstruction; MAO therapy; use in newborn or premature infants and in breast-feeding mothers.
[#printed] => 1 ) [#title] => [#description] => [#children] =>Contraindications:
Hypersensitivity to antihistamines; narrow-angle glaucoma; stenosing peptic ulcer; symptomatic prostatic hypertrophy; asthmatic attack; bladder neck obstruction; pyloroduodenal obstruction; MAO therapy; use in newborn or premature infants and in breast-feeding mothers.
Allergy symptoms
Assess allergy symptoms (eg, cough, rhinitis, nasal congestion, sneezing, watery eyes, or itching nose, throat, or eyes) before starting therapy and periodically during therapy. Notify health care provider if symptoms are not improving or are getting worse.
Dizziness/Drowsiness
Monitor patient for dizziness and excessive drowsiness. If noted, hold therapy and notify health care provider.
Review therapy
Ensure therapy periodically is reviewed to determine if it needs to be continued without change or if a dose change (eg, increase, decrease, discontinuation) is indicated.
Allergy symptoms
Assess allergy symptoms (eg, cough, rhinitis, nasal congestion, sneezing, watery eyes, or itching nose, throat, or eyes) before starting therapy and periodically during therapy. Notify health care provider if symptoms are not improving or are getting worse.
Dizziness/Drowsiness
Monitor patient for dizziness and excessive drowsiness. If noted, hold therapy and notify health care provider.
Review therapy
Ensure therapy periodically is reviewed to determine if it needs to be continued without change or if a dose change (eg, increase, decrease, discontinuation) is indicated.
Allergy symptoms
Assess allergy symptoms (eg, cough, rhinitis, nasal congestion, sneezing, watery eyes, or itching nose, throat, or eyes) before starting therapy and periodically during therapy. Notify health care provider if symptoms are not improving or are getting worse.
Dizziness/Drowsiness
Monitor patient for dizziness and excessive drowsiness. If noted, hold therapy and notify health care provider.
Review therapy
Ensure therapy periodically is reviewed to determine if it needs to be continued without change or if a dose change (eg, increase, decrease, discontinuation) is indicated.
Allergy symptoms
Assess allergy symptoms (eg, cough, rhinitis, nasal congestion, sneezing, watery eyes, or itching nose, throat, or eyes) before starting therapy and periodically during therapy. Notify health care provider if symptoms are not improving or are getting worse.
Dizziness/Drowsiness
Monitor patient for dizziness and excessive drowsiness. If noted, hold therapy and notify health care provider.
Review therapy
Ensure therapy periodically is reviewed to determine if it needs to be continued without change or if a dose change (eg, increase, decrease, discontinuation) is indicated.
Allergy symptoms
Assess allergy symptoms (eg, cough, rhinitis, nasal congestion, sneezing, watery eyes, or itching nose, throat, or eyes) before starting therapy and periodically during therapy. Notify health care provider if symptoms are not improving or are getting worse.
Dizziness/Drowsiness
Monitor patient for dizziness and excessive drowsiness. If noted, hold therapy and notify health care provider.
Review therapy
Ensure therapy periodically is reviewed to determine if it needs to be continued without change or if a dose change (eg, increase, decrease, discontinuation) is indicated.
Precautions:
Allergy symptoms
Assess allergy symptoms (eg, cough, rhinitis, nasal congestion, sneezing, watery eyes, or itching nose, throat, or eyes) before starting therapy and periodically during therapy. Notify health care provider if symptoms are not improving or are getting worse.
Dizziness/Drowsiness
Monitor patient for dizziness and excessive drowsiness. If noted, hold therapy and notify health care provider.
Review therapy
Ensure therapy periodically is reviewed to determine if it needs to be continued without change or if a dose change (eg, increase, decrease, discontinuation) is indicated.
Alcohol, CNS depressants, and tricyclic antidepressants
May cause additive CNS depressant effects.
MAOIs
May increase anticholinergic effects of chlorpheniramine.
Ototoxic medications
Concurrent use may mask the symptoms of ototoxicity.
Alcohol, CNS depressants, and tricyclic antidepressants
May cause additive CNS depressant effects.
MAOIs
May increase anticholinergic effects of chlorpheniramine.
Ototoxic medications
Concurrent use may mask the symptoms of ototoxicity.
Alcohol, CNS depressants, and tricyclic antidepressants
May cause additive CNS depressant effects.
MAOIs
May increase anticholinergic effects of chlorpheniramine.
Ototoxic medications
Concurrent use may mask the symptoms of ototoxicity.
Alcohol, CNS depressants, and tricyclic antidepressants
May cause additive CNS depressant effects.
MAOIs
May increase anticholinergic effects of chlorpheniramine.
Ototoxic medications
Concurrent use may mask the symptoms of ototoxicity.
Drug Interactions:
Alcohol, CNS depressants, and tricyclic antidepressants
May cause additive CNS depressant effects.
MAOIs
May increase anticholinergic effects of chlorpheniramine.
Ototoxic medications
Concurrent use may mask the symptoms of ototoxicity.
• fast or uneven heart rate;
• mood changes;
• tremor, seizure (convulsions);
• easy bruising or bleeding, unusual weakness;
• feeling short of breath; or
• little or no urinating.
Common side effects may include:
• dizziness, drowsiness;
• dry mouth, nose, or throat;
• constipation;
• blurred vision; or
• feeling nervous or restless.
• fast or uneven heart rate;
• mood changes;
• tremor, seizure (convulsions);
• easy bruising or bleeding, unusual weakness;
• feeling short of breath; or
• little or no urinating.
Common side effects may include:
• dizziness, drowsiness;
• dry mouth, nose, or throat;
• constipation;
• blurred vision; or
• feeling nervous or restless.
• fast or uneven heart rate;
• mood changes;
• tremor, seizure (convulsions);
• easy bruising or bleeding, unusual weakness;
• feeling short of breath; or
• little or no urinating.
Common side effects may include:
• dizziness, drowsiness;
• dry mouth, nose, or throat;
• constipation;
• blurred vision; or
• feeling nervous or restless.
• fast or uneven heart rate;
• mood changes;
• tremor, seizure (convulsions);
• easy bruising or bleeding, unusual weakness;
• feeling short of breath; or
• little or no urinating.
Common side effects may include:
• dizziness, drowsiness;
• dry mouth, nose, or throat;
• constipation;
• blurred vision; or
• feeling nervous or restless.
Side Effects:
• fast or uneven heart rate;
• mood changes;
• tremor, seizure (convulsions);
• easy bruising or bleeding, unusual weakness;
• feeling short of breath; or
• little or no urinating.
Common side effects may include:
• dizziness, drowsiness;
• dry mouth, nose, or throat;
• constipation;
• blurred vision; or
• feeling nervous or restless.
• Store below 30 C°
• Protect from light and freezing
• Store below 30 C°
• Protect from light and freezing
• Store below 30 C°
• Protect from light and freezing
• Store below 30 C°
• Protect from light and freezing
Storage:
• Store below 30 C°
• Protect from light and freezing
• Injection 10mg/1ml: Box of 5 ampoules
[#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] =>• Injection 10mg/1ml: Box of 5 ampoules
) [#title] => [#description] => [#children] =>• Injection 10mg/1ml: Box of 5 ampoules
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[#printed] => 1 ) [#title] => [#description] => [#children] =>Packing:
• Injection 10mg/1ml: Box of 5 ampoules
PDF:
Image:
Brand Name:
HISTADIC®
Dosage Form:
Injection 10mg/1ml
Pharmacological Category:
H 1 Blocker
Therapeutic Category:
Antihistamines
Pregnancy Category:
Category C
Competitively antagonizes histamine at H 1 receptor sites.
Pharmacokinetics:
Absorption
Readily absorbed.
Distribution
72% protein bound.
Metabolism
Metabolized predominantly in the liver, but also in the lung and kidneys.
Elimination
Renally eliminated, mostly as metabolites within 24 h.
Indications:
Temporary relief of sneezing, itchy, watery eyes, itchy nose or throat, and runny nose caused by hay fever (allergic rhinitis), or other respiratory allergies.
Contraindications:
Hypersensitivity to antihistamines; narrow-angle glaucoma; stenosing peptic ulcer; symptomatic prostatic hypertrophy; asthmatic attack; bladder neck obstruction; pyloroduodenal obstruction; MAO therapy; use in newborn or premature infants and in breast-feeding mothers.
Precautions:
Allergy symptoms
Assess allergy symptoms (eg, cough, rhinitis, nasal congestion, sneezing, watery eyes, or itching nose, throat, or eyes) before starting therapy and periodically during therapy. Notify health care provider if symptoms are not improving or are getting worse.
Dizziness/Drowsiness
Monitor patient for dizziness and excessive drowsiness. If noted, hold therapy and notify health care provider.
Review therapy
Ensure therapy periodically is reviewed to determine if it needs to be continued without change or if a dose change (eg, increase, decrease, discontinuation) is indicated.
Drug Interactions:
Alcohol, CNS depressants, and tricyclic antidepressants
May cause additive CNS depressant effects.
MAOIs
May increase anticholinergic effects of chlorpheniramine.
Ototoxic medications
Concurrent use may mask the symptoms of ototoxicity.
Side Effects:
• fast or uneven heart rate;
• mood changes;
• tremor, seizure (convulsions);
• easy bruising or bleeding, unusual weakness;
• feeling short of breath; or
• little or no urinating.
Common side effects may include:
• dizziness, drowsiness;
• dry mouth, nose, or throat;
• constipation;
• blurred vision; or
• feeling nervous or restless.
Storage:
• Store below 30 C°
• Protect from light and freezing
Packing:
• Injection 10mg/1ml: Box of 5 ampoules
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