Tramadol

Generic Name: Tramadol
Brand Name: Tramadic®
Dosage Form: Injection50mg/1ml
Pharmacological Category: Opioid agonist
Therapeutic Category: Analgesic
Pregnancy Category: category C

Pharmacology

Inhibits reuptake of serotonin and norepinephrine in CNS

Pharmacokinetics:

The bioavailability of tramadol hydrochloride after intramuscular injection or intravenous administration is the same; the mean peak serum concentration is achieved after 45 minutes. Tramadol hydrochloride is primarily metabolised in the liver (90%) with one of its metabolites, mono-O-desmethyltramadol (M1), being 2 to 4 times as potent as the parent compound. Tramadol hydrochloride has a linear pharmacokinetic profile within the therapeutic dosage range.
Tramadol hydrochloride and its metabolites are excreted mainly in the urine. The elimination half-life is 5 to 7 hours, but is prolonged in impaired hepatic and renal function.
Tramadol hydrochloride crosses the blood-brain and placental barrier. Small amounts are excreted in breast milk unchanged or as the metabolite M1.

Indications:

Moderate to moderately severe pain

Contraindications:

• Hypersensitivity to drug, its components, or opioids
• Acute intoxication with alcohol, sedative-hypnotics, centrally acting analgesics, opioid analgesics, or psychotropic agents
• Physical opioid dependence

Precautions:

Use cautiously in:
• seizure disorder or risk factors for seizures, renal or hepatic impairment, increased intracranial pressure, head trauma, acute abdomen
• history of opioid dependence or recent use of large opioid doses
• elderly patients
• pregnant or breastfeeding patients
• children younger than age 16 (safety not established)

Drug Interactions:

Anesthetics, antihistamines, CNS depressants, other opioids, psychotropic agents, sedative-hypnotics: increased risk of CNS depression
Carbamazepine: increased tramadol metabolism and decreased efficacy
MAO inhibitors: increased risk of serotonin syndrome and seizures

Side Effects:

CNS: dizziness, vertigo, headache, drowsiness, anxiety, stimulation, confusion, incoordination, euphoria, nervousness, sleep disorder, asthenia, hypertonia, seizures
CV: vasodilation
EENT: visual disturbances
GI: nausea, vomiting, diarrhea, constipation, abdominal pain, dyspepsia, flatulence, dry mouth, anorexia
GU: urinary retention and frequency, proteinuria, menopausal symptoms
Respiratory: respiratory depression (with large doses, concomitant anesthetic use, or alcohol ingestion)
Skin: pruritus, sweating
Other: physical or psychological drug dependence, drug tolerance

Storage:

• Storage: Store below 30 C°
• Protect from light and freezing

Packing:

Tramadol Injection 50mg / 1ml : 5 ampoules/box

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Image: 
Brand Name: 

Tramadic®

Dosage Form: 

Injection50mg/1ml

Pharmacological Category: 

Opioid agonist

Therapeutic Category: 

Analgesic

Pregnancy Category: 

category C

Inhibits reuptake of serotonin and norepinephrine in CNS

Pharmacokinetics: 

The bioavailability of tramadol hydrochloride after intramuscular injection or intravenous administration is the same; the mean peak serum concentration is achieved after 45 minutes. Tramadol hydrochloride is primarily metabolised in the liver (90%) with one of its metabolites, mono-O-desmethyltramadol (M1), being 2 to 4 times as potent as the parent compound. Tramadol hydrochloride has a linear pharmacokinetic profile within the therapeutic dosage range.
Tramadol hydrochloride and its metabolites are excreted mainly in the urine. The elimination half-life is 5 to 7 hours, but is prolonged in impaired hepatic and renal function.
Tramadol hydrochloride crosses the blood-brain and placental barrier. Small amounts are excreted in breast milk unchanged or as the metabolite M1.

Indications: 

Moderate to moderately severe pain

Contraindications: 

• Hypersensitivity to drug, its components, or opioids
• Acute intoxication with alcohol, sedative-hypnotics, centrally acting analgesics, opioid analgesics, or psychotropic agents
• Physical opioid dependence

Precautions: 

Use cautiously in:
• seizure disorder or risk factors for seizures, renal or hepatic impairment, increased intracranial pressure, head trauma, acute abdomen
• history of opioid dependence or recent use of large opioid doses
• elderly patients
• pregnant or breastfeeding patients
• children younger than age 16 (safety not established)

Drug Interactions: 

Anesthetics, antihistamines, CNS depressants, other opioids, psychotropic agents, sedative-hypnotics: increased risk of CNS depression
Carbamazepine: increased tramadol metabolism and decreased efficacy
MAO inhibitors: increased risk of serotonin syndrome and seizures

Side Effects: 

CNS: dizziness, vertigo, headache, drowsiness, anxiety, stimulation, confusion, incoordination, euphoria, nervousness, sleep disorder, asthenia, hypertonia, seizures
CV: vasodilation
EENT: visual disturbances
GI: nausea, vomiting, diarrhea, constipation, abdominal pain, dyspepsia, flatulence, dry mouth, anorexia
GU: urinary retention and frequency, proteinuria, menopausal symptoms
Respiratory: respiratory depression (with large doses, concomitant anesthetic use, or alcohol ingestion)
Skin: pruritus, sweating
Other: physical or psychological drug dependence, drug tolerance

Storage: 

• Storage: Store below 30 C°
• Protect from light and freezing

Packing: 

Tramadol Injection 50mg / 1ml : 5 ampoules/box

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• Acute intoxication with alcohol, sedative-hypnotics, centrally acting analgesics, opioid analgesics, or psychotropic agents
• Physical opioid dependence

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MAO inhibitors: increased risk of serotonin syndrome and seizures

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Anesthetics, antihistamines, CNS depressants, other opioids, psychotropic agents, sedative-hypnotics: increased risk of CNS depression
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Tramadol hydrochloride and its metabolites are excreted mainly in the urine. The elimination half-life is 5 to 7 hours, but is prolonged in impaired hepatic and renal function.
Tramadol hydrochloride crosses the blood-brain and placental barrier. Small amounts are excreted in breast milk unchanged or as the metabolite M1.

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The bioavailability of tramadol hydrochloride after intramuscular injection or intravenous administration is the same; the mean peak serum concentration is achieved after 45 minutes. Tramadol hydrochloride is primarily metabolised in the liver (90%) with one of its metabolites, mono-O-desmethyltramadol (M1), being 2 to 4 times as potent as the parent compound. Tramadol hydrochloride has a linear pharmacokinetic profile within the therapeutic dosage range.
Tramadol hydrochloride and its metabolites are excreted mainly in the urine. The elimination half-life is 5 to 7 hours, but is prolonged in impaired hepatic and renal function.
Tramadol hydrochloride crosses the blood-brain and placental barrier. Small amounts are excreted in breast milk unchanged or as the metabolite M1.

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• elderly patients
• pregnant or breastfeeding patients
• children younger than age 16 (safety not established)

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• seizure disorder or risk factors for seizures, renal or hepatic impairment, increased intracranial pressure, head trauma, acute abdomen
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• elderly patients
• pregnant or breastfeeding patients
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GU: urinary retention and frequency, proteinuria, menopausal symptoms
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Skin: pruritus, sweating
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CV: vasodilation
EENT: visual disturbances
GI: nausea, vomiting, diarrhea, constipation, abdominal pain, dyspepsia, flatulence, dry mouth, anorexia
GU: urinary retention and frequency, proteinuria, menopausal symptoms
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Skin: pruritus, sweating
Other: physical or psychological drug dependence, drug tolerance

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• Protect from light and freezing

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• Protect from light and freezing

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Inhibits reuptake of serotonin and norepinephrine in CNS

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The bioavailability of tramadol hydrochloride after intramuscular injection or intravenous administration is the same; the mean peak serum concentration is achieved after 45 minutes. Tramadol hydrochloride is primarily metabolised in the liver (90%) with one of its metabolites, mono-O-desmethyltramadol (M1), being 2 to 4 times as potent as the parent compound. Tramadol hydrochloride has a linear pharmacokinetic profile within the therapeutic dosage range.
Tramadol hydrochloride and its metabolites are excreted mainly in the urine. The elimination half-life is 5 to 7 hours, but is prolonged in impaired hepatic and renal function.
Tramadol hydrochloride crosses the blood-brain and placental barrier. Small amounts are excreted in breast milk unchanged or as the metabolite M1.

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The bioavailability of tramadol hydrochloride after intramuscular injection or intravenous administration is the same; the mean peak serum concentration is achieved after 45 minutes. Tramadol hydrochloride is primarily metabolised in the liver (90%) with one of its metabolites, mono-O-desmethyltramadol (M1), being 2 to 4 times as potent as the parent compound. Tramadol hydrochloride has a linear pharmacokinetic profile within the therapeutic dosage range.
Tramadol hydrochloride and its metabolites are excreted mainly in the urine. The elimination half-life is 5 to 7 hours, but is prolonged in impaired hepatic and renal function.
Tramadol hydrochloride crosses the blood-brain and placental barrier. Small amounts are excreted in breast milk unchanged or as the metabolite M1.

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The bioavailability of tramadol hydrochloride after intramuscular injection or intravenous administration is the same; the mean peak serum concentration is achieved after 45 minutes. Tramadol hydrochloride is primarily metabolised in the liver (90%) with one of its metabolites, mono-O-desmethyltramadol (M1), being 2 to 4 times as potent as the parent compound. Tramadol hydrochloride has a linear pharmacokinetic profile within the therapeutic dosage range.
Tramadol hydrochloride and its metabolites are excreted mainly in the urine. The elimination half-life is 5 to 7 hours, but is prolonged in impaired hepatic and renal function.
Tramadol hydrochloride crosses the blood-brain and placental barrier. Small amounts are excreted in breast milk unchanged or as the metabolite M1.

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The bioavailability of tramadol hydrochloride after intramuscular injection or intravenous administration is the same; the mean peak serum concentration is achieved after 45 minutes. Tramadol hydrochloride is primarily metabolised in the liver (90%) with one of its metabolites, mono-O-desmethyltramadol (M1), being 2 to 4 times as potent as the parent compound. Tramadol hydrochloride has a linear pharmacokinetic profile within the therapeutic dosage range.
Tramadol hydrochloride and its metabolites are excreted mainly in the urine. The elimination half-life is 5 to 7 hours, but is prolonged in impaired hepatic and renal function.
Tramadol hydrochloride crosses the blood-brain and placental barrier. Small amounts are excreted in breast milk unchanged or as the metabolite M1.

[#printed] => 1 ) [#title] => [#description] => [#children] =>
Pharmacokinetics: 

The bioavailability of tramadol hydrochloride after intramuscular injection or intravenous administration is the same; the mean peak serum concentration is achieved after 45 minutes. Tramadol hydrochloride is primarily metabolised in the liver (90%) with one of its metabolites, mono-O-desmethyltramadol (M1), being 2 to 4 times as potent as the parent compound. Tramadol hydrochloride has a linear pharmacokinetic profile within the therapeutic dosage range.
Tramadol hydrochloride and its metabolites are excreted mainly in the urine. The elimination half-life is 5 to 7 hours, but is prolonged in impaired hepatic and renal function.
Tramadol hydrochloride crosses the blood-brain and placental barrier. Small amounts are excreted in breast milk unchanged or as the metabolite M1.

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Moderate to moderately severe pain

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Moderate to moderately severe pain

) [#title] => [#description] => [#children] =>

Moderate to moderately severe pain

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Moderate to moderately severe pain

[#printed] => 1 ) [#title] => [#description] => [#children] =>
Indications: 

Moderate to moderately severe pain

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• Hypersensitivity to drug, its components, or opioids
• Acute intoxication with alcohol, sedative-hypnotics, centrally acting analgesics, opioid analgesics, or psychotropic agents
• Physical opioid dependence

[#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] =>

• Hypersensitivity to drug, its components, or opioids
• Acute intoxication with alcohol, sedative-hypnotics, centrally acting analgesics, opioid analgesics, or psychotropic agents
• Physical opioid dependence

) [#title] => [#description] => [#children] =>

• Hypersensitivity to drug, its components, or opioids
• Acute intoxication with alcohol, sedative-hypnotics, centrally acting analgesics, opioid analgesics, or psychotropic agents
• Physical opioid dependence

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• Hypersensitivity to drug, its components, or opioids
• Acute intoxication with alcohol, sedative-hypnotics, centrally acting analgesics, opioid analgesics, or psychotropic agents
• Physical opioid dependence

[#printed] => 1 ) [#title] => [#description] => [#children] =>
Contraindications: 

• Hypersensitivity to drug, its components, or opioids
• Acute intoxication with alcohol, sedative-hypnotics, centrally acting analgesics, opioid analgesics, or psychotropic agents
• Physical opioid dependence

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Use cautiously in:
• seizure disorder or risk factors for seizures, renal or hepatic impairment, increased intracranial pressure, head trauma, acute abdomen
• history of opioid dependence or recent use of large opioid doses
• elderly patients
• pregnant or breastfeeding patients
• children younger than age 16 (safety not established)

[#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] =>

Use cautiously in:
• seizure disorder or risk factors for seizures, renal or hepatic impairment, increased intracranial pressure, head trauma, acute abdomen
• history of opioid dependence or recent use of large opioid doses
• elderly patients
• pregnant or breastfeeding patients
• children younger than age 16 (safety not established)

) [#title] => [#description] => [#children] =>

Use cautiously in:
• seizure disorder or risk factors for seizures, renal or hepatic impairment, increased intracranial pressure, head trauma, acute abdomen
• history of opioid dependence or recent use of large opioid doses
• elderly patients
• pregnant or breastfeeding patients
• children younger than age 16 (safety not established)

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Use cautiously in:
• seizure disorder or risk factors for seizures, renal or hepatic impairment, increased intracranial pressure, head trauma, acute abdomen
• history of opioid dependence or recent use of large opioid doses
• elderly patients
• pregnant or breastfeeding patients
• children younger than age 16 (safety not established)

[#printed] => 1 ) [#title] => [#description] => [#children] =>
Precautions: 

Use cautiously in:
• seizure disorder or risk factors for seizures, renal or hepatic impairment, increased intracranial pressure, head trauma, acute abdomen
• history of opioid dependence or recent use of large opioid doses
• elderly patients
• pregnant or breastfeeding patients
• children younger than age 16 (safety not established)

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Anesthetics, antihistamines, CNS depressants, other opioids, psychotropic agents, sedative-hypnotics: increased risk of CNS depression
Carbamazepine: increased tramadol metabolism and decreased efficacy
MAO inhibitors: increased risk of serotonin syndrome and seizures

[#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] =>

Anesthetics, antihistamines, CNS depressants, other opioids, psychotropic agents, sedative-hypnotics: increased risk of CNS depression
Carbamazepine: increased tramadol metabolism and decreased efficacy
MAO inhibitors: increased risk of serotonin syndrome and seizures

) [#title] => [#description] => [#children] =>

Anesthetics, antihistamines, CNS depressants, other opioids, psychotropic agents, sedative-hypnotics: increased risk of CNS depression
Carbamazepine: increased tramadol metabolism and decreased efficacy
MAO inhibitors: increased risk of serotonin syndrome and seizures

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Anesthetics, antihistamines, CNS depressants, other opioids, psychotropic agents, sedative-hypnotics: increased risk of CNS depression
Carbamazepine: increased tramadol metabolism and decreased efficacy
MAO inhibitors: increased risk of serotonin syndrome and seizures

[#printed] => 1 ) [#title] => [#description] => [#children] =>
Drug Interactions: 

Anesthetics, antihistamines, CNS depressants, other opioids, psychotropic agents, sedative-hypnotics: increased risk of CNS depression
Carbamazepine: increased tramadol metabolism and decreased efficacy
MAO inhibitors: increased risk of serotonin syndrome and seizures

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CNS: dizziness, vertigo, headache, drowsiness, anxiety, stimulation, confusion, incoordination, euphoria, nervousness, sleep disorder, asthenia, hypertonia, seizures
CV: vasodilation
EENT: visual disturbances
GI: nausea, vomiting, diarrhea, constipation, abdominal pain, dyspepsia, flatulence, dry mouth, anorexia
GU: urinary retention and frequency, proteinuria, menopausal symptoms
Respiratory: respiratory depression (with large doses, concomitant anesthetic use, or alcohol ingestion)
Skin: pruritus, sweating
Other: physical or psychological drug dependence, drug tolerance

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CNS: dizziness, vertigo, headache, drowsiness, anxiety, stimulation, confusion, incoordination, euphoria, nervousness, sleep disorder, asthenia, hypertonia, seizures
CV: vasodilation
EENT: visual disturbances
GI: nausea, vomiting, diarrhea, constipation, abdominal pain, dyspepsia, flatulence, dry mouth, anorexia
GU: urinary retention and frequency, proteinuria, menopausal symptoms
Respiratory: respiratory depression (with large doses, concomitant anesthetic use, or alcohol ingestion)
Skin: pruritus, sweating
Other: physical or psychological drug dependence, drug tolerance

) [#title] => [#description] => [#children] =>

CNS: dizziness, vertigo, headache, drowsiness, anxiety, stimulation, confusion, incoordination, euphoria, nervousness, sleep disorder, asthenia, hypertonia, seizures
CV: vasodilation
EENT: visual disturbances
GI: nausea, vomiting, diarrhea, constipation, abdominal pain, dyspepsia, flatulence, dry mouth, anorexia
GU: urinary retention and frequency, proteinuria, menopausal symptoms
Respiratory: respiratory depression (with large doses, concomitant anesthetic use, or alcohol ingestion)
Skin: pruritus, sweating
Other: physical or psychological drug dependence, drug tolerance

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CNS: dizziness, vertigo, headache, drowsiness, anxiety, stimulation, confusion, incoordination, euphoria, nervousness, sleep disorder, asthenia, hypertonia, seizures
CV: vasodilation
EENT: visual disturbances
GI: nausea, vomiting, diarrhea, constipation, abdominal pain, dyspepsia, flatulence, dry mouth, anorexia
GU: urinary retention and frequency, proteinuria, menopausal symptoms
Respiratory: respiratory depression (with large doses, concomitant anesthetic use, or alcohol ingestion)
Skin: pruritus, sweating
Other: physical or psychological drug dependence, drug tolerance

[#printed] => 1 ) [#title] => [#description] => [#children] =>
Side Effects: 

CNS: dizziness, vertigo, headache, drowsiness, anxiety, stimulation, confusion, incoordination, euphoria, nervousness, sleep disorder, asthenia, hypertonia, seizures
CV: vasodilation
EENT: visual disturbances
GI: nausea, vomiting, diarrhea, constipation, abdominal pain, dyspepsia, flatulence, dry mouth, anorexia
GU: urinary retention and frequency, proteinuria, menopausal symptoms
Respiratory: respiratory depression (with large doses, concomitant anesthetic use, or alcohol ingestion)
Skin: pruritus, sweating
Other: physical or psychological drug dependence, drug tolerance

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• Storage: Store below 30 C°
• Protect from light and freezing

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• Storage: Store below 30 C°
• Protect from light and freezing

) [#title] => [#description] => [#children] =>

• Storage: Store below 30 C°
• Protect from light and freezing

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• Storage: Store below 30 C°
• Protect from light and freezing

[#printed] => 1 ) [#title] => [#description] => [#children] =>
Storage: 

• Storage: Store below 30 C°
• Protect from light and freezing

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Tramadol Injection 50mg / 1ml : 5 ampoules/box

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Tramadol Injection 50mg / 1ml : 5 ampoules/box

) [#title] => [#description] => [#children] =>

Tramadol Injection 50mg / 1ml : 5 ampoules/box

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Tramadol Injection 50mg / 1ml : 5 ampoules/box

[#printed] => 1 ) [#title] => [#description] => [#children] =>
Packing: 

Tramadol Injection 50mg / 1ml : 5 ampoules/box

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Image: 
Brand Name: 

Tramadic®

Dosage Form: 

Injection50mg/1ml

Pharmacological Category: 

Opioid agonist

Therapeutic Category: 

Analgesic

Pregnancy Category: 

category C

Inhibits reuptake of serotonin and norepinephrine in CNS

Pharmacokinetics: 

The bioavailability of tramadol hydrochloride after intramuscular injection or intravenous administration is the same; the mean peak serum concentration is achieved after 45 minutes. Tramadol hydrochloride is primarily metabolised in the liver (90%) with one of its metabolites, mono-O-desmethyltramadol (M1), being 2 to 4 times as potent as the parent compound. Tramadol hydrochloride has a linear pharmacokinetic profile within the therapeutic dosage range.
Tramadol hydrochloride and its metabolites are excreted mainly in the urine. The elimination half-life is 5 to 7 hours, but is prolonged in impaired hepatic and renal function.
Tramadol hydrochloride crosses the blood-brain and placental barrier. Small amounts are excreted in breast milk unchanged or as the metabolite M1.

Indications: 

Moderate to moderately severe pain

Contraindications: 

• Hypersensitivity to drug, its components, or opioids
• Acute intoxication with alcohol, sedative-hypnotics, centrally acting analgesics, opioid analgesics, or psychotropic agents
• Physical opioid dependence

Precautions: 

Use cautiously in:
• seizure disorder or risk factors for seizures, renal or hepatic impairment, increased intracranial pressure, head trauma, acute abdomen
• history of opioid dependence or recent use of large opioid doses
• elderly patients
• pregnant or breastfeeding patients
• children younger than age 16 (safety not established)

Drug Interactions: 

Anesthetics, antihistamines, CNS depressants, other opioids, psychotropic agents, sedative-hypnotics: increased risk of CNS depression
Carbamazepine: increased tramadol metabolism and decreased efficacy
MAO inhibitors: increased risk of serotonin syndrome and seizures

Side Effects: 

CNS: dizziness, vertigo, headache, drowsiness, anxiety, stimulation, confusion, incoordination, euphoria, nervousness, sleep disorder, asthenia, hypertonia, seizures
CV: vasodilation
EENT: visual disturbances
GI: nausea, vomiting, diarrhea, constipation, abdominal pain, dyspepsia, flatulence, dry mouth, anorexia
GU: urinary retention and frequency, proteinuria, menopausal symptoms
Respiratory: respiratory depression (with large doses, concomitant anesthetic use, or alcohol ingestion)
Skin: pruritus, sweating
Other: physical or psychological drug dependence, drug tolerance

Storage: 

• Storage: Store below 30 C°
• Protect from light and freezing

Packing: 

Tramadol Injection 50mg / 1ml : 5 ampoules/box

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button

CONTACT US:

Head Office:
Address: No.1, Beastoon Ave., Dr. Fatemi Sq., Tehran1431663135 Iran
Tel: (+98 21)-889 65323
Fax: (+98 21)-889 57056
Factory:
Address: Caspian tamin Pharmaceutical Co., Entrance 1, Rasht Industrial Zone, Rasht, Guilan, Iran
Tel: (+98 131) 338-2511- 8
Fax: (+98 131) 338 – 2517